| Jeffrey Wm. Bartelt |
U.S. Citizen |
300200 |
0 |
300200 |
0 |
300200 |
5.2 % |
24/02/2016 |
| Mark N. Lampert |
United States |
0 |
678400 |
0 |
0 |
678400 |
11.8 % |
05/06/2015 |
| MSI BVF SPV, LLC |
Delaware |
0 |
96726 |
0 |
0 |
96726 |
1.7 % |
05/06/2015 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
330947 |
0 |
0 |
330947 |
5.8 % |
05/06/2015 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
190041 |
0 |
0 |
190041 |
3.3 % |
05/06/2015 |
| Investment 10, L.L.C. |
Illinois |
0 |
60686 |
0 |
0 |
60686 |
1.1 % |
05/06/2015 |
| BVF Partners L.P. |
Delaware |
0 |
678400 |
0 |
0 |
678400 |
11.8 % |
05/06/2015 |
| BVF Inc. |
Delaware |
0 |
678400 |
0 |
0 |
678400 |
11.8 % |
05/06/2015 |
| HealthCare Ventures VII, L.P. |
Delaware |
0 |
593153 |
0 |
0 |
593153 |
10.3 % |
17/07/2014 |
| HealthCare Partners VII, L.P. |
Delaware |
0 |
593153 |
0 |
0 |
593153 |
10.3 % |
17/07/2014 |
| Christopher Mirabelli, Ph.D. |
USA |
0 |
593153 |
0 |
0 |
593153 |
10.3 % |
17/07/2014 |
| Augustine Lawlor |
USA |
0 |
593153 |
0 |
0 |
593153 |
10.3 % |
17/07/2014 |
| Harold R. Werner |
USA |
0 |
593153 |
0 |
0 |
593153 |
10.3 % |
17/07/2014 |
| John W. Littlechild |
USA |
0 |
593153 |
0 |
0 |
593153 |
10.3 % |
17/07/2014 |
| James H. Cavanaugh, Ph.D. |
USA |
0 |
593153 |
0 |
0 |
593153 |
10.3 % |
17/07/2014 |
| S James W. Broderick (“Broderick”) |
United States |
0 |
539347 |
0 |
0 |
539347 |
9.4 % |
11/07/2014 |
| S Gary J. Morgenthaler (“Morgenthaler”) |
United States |
0 |
539347 |
0 |
0 |
539347 |
9.4 % |
11/07/2014 |
| S Gary R. Little (“Little”) |
United States |
0 |
539347 |
0 |
0 |
539347 |
9.4 % |
11/07/2014 |
| S John D. Lutsi (“Lutsi”) |
United States |
0 |
539347 |
0 |
0 |
539347 |
9.4 % |
11/07/2014 |
| S Robert D. Pavey (“Pavey”) |
United States |
0 |
539347 |
0 |
0 |
539347 |
9.4 % |
11/07/2014 |
| S Peter G. Taft (“Taft”) |
United States |
0 |
539347 |
0 |
0 |
539347 |
9.4 % |
11/07/2014 |
| S Morgenthaler Partners VII, L.P. (“Morgenthaler VII”) |
Delaware |
539347 |
539347 |
539347 |
0 |
539347 |
9.4 % |
11/07/2014 |
| S Morgenthaler Management Partners VII, LLC (“Morgenthaler VII GP”) |
Delaware |
539347 |
539347 |
539347 |
0 |
539347 |
9.4 % |
11/07/2014 |
| S Robert C. Bellas, Jr. (“Bellas”) |
United States |
0 |
539347 |
0 |
0 |
539347 |
9.4 % |
11/07/2014 |