Brown Capital Management, LLC |
State of Maryland |
923518 |
0 |
1634591 |
0 |
1634591 |
2.97 % |
14/11/2024 |
Brown Capital Management, LLC |
State of Maryland |
1835076 |
0 |
2697794 |
0 |
2697794 |
5.53 % |
14/02/2024 |
The Vanguard Group |
Pennsylvania |
0 |
86409 |
5101020 |
135718 |
5236738 |
10.73 % |
13/02/2024 |
FMR LLC |
Delaware |
5889438 |
0 |
5893983 |
0 |
5893983 |
12.059 % |
09/02/2024 |
Abigail P. Johnson |
United States of America |
0 |
0 |
5893983 |
0 |
5893983 |
12.059 % |
09/02/2024 |
BlackRock, Inc. |
Delaware |
7805217 |
0 |
7894315 |
0 |
7894315 |
16.2 % |
22/01/2024 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
1096068 |
0 |
1340500 |
1340500 |
2.75 % |
10/01/2024 |
Wellington Management Group LLP |
Massachusetts |
0 |
1096068 |
0 |
1340500 |
1340500 |
2.75 % |
10/01/2024 |
Wellington Group Holdings LLP |
Delaware |
0 |
1096068 |
0 |
1340500 |
1340500 |
2.75 % |
10/01/2024 |
Wellington Management Group LLP |
Massachusetts |
0 |
1096068 |
0 |
1340500 |
1340500 |
2.75 % |
10/01/2024 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
1096068 |
0 |
1340500 |
1340500 |
2.75 % |
10/01/2024 |
Wellington Group Holdings LLP |
Delaware |
0 |
1096068 |
0 |
1340500 |
1340500 |
2.75 % |
10/01/2024 |
FMR LLC |
Delaware |
4995175 |
0 |
4996960 |
0 |
4996960 |
10.224 % |
11/12/2023 |
FMR LLC |
Delaware |
4995175 |
0 |
4996960 |
0 |
4996960 |
10.224 % |
11/12/2023 |
Abigail P. Johnson |
United States of America |
0 |
0 |
4996960 |
0 |
4996960 |
10.224 % |
11/12/2023 |
Abigail P. Johnson |
United States of America |
0 |
0 |
4996960 |
0 |
4996960 |
10.224 % |
11/12/2023 |
Thomas W. Burns |
USA |
2707641 |
100000 |
2707641 |
100000 |
2807641 |
5.71 % |
14/02/2023 |
Thomas W. Burns |
USA |
2707641 |
100000 |
2707641 |
100000 |
2807641 |
5.71 % |
14/02/2023 |
The Vanguard Group |
Pennsylvania For |
0 |
77990 |
5223898 |
125327 |
5349225 |
11.21 % |
09/02/2023 |
Wellington Management Group LLP |
Massachusetts |
0 |
3991490 |
0 |
4385656 |
4385656 |
9.19 % |
06/02/2023 |
Wellington Management Company LLP |
Delaware |
0 |
3985052 |
0 |
4271899 |
4271899 |
8.96 % |
06/02/2023 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
3991490 |
0 |
4385656 |
4385656 |
9.19 % |
06/02/2023 |
Wellington Group Holdings LLP |
Delaware |
0 |
3991490 |
0 |
4385656 |
4385656 |
9.19 % |
06/02/2023 |
BlackRock, Inc. |
Delaware |
7726239 |
0 |
7783794 |
0 |
7783794 |
16.3 % |
31/01/2023 |
Thomas W. Burns |
USA |
2625557 |
100000 |
2625557 |
100000 |
2725557 |
5.65 % |
14/02/2022 |
Brown Capital Management, LLC |
State of Maryland |
2085037 |
0 |
3021796 |
0 |
3021796 |
6.44 % |
14/02/2022 |
The Vanguard Group |
Pennsylvania For |
0 |
86732 |
4989144 |
127451 |
5116595 |
10.91 % |
10/02/2022 |
Artisan Partners Holdings LP |
Delaware |
0 |
1642523 |
0 |
1983513 |
1983513 |
4.2 % |
04/02/2022 |
Artisan Investments GP LLC |
Delaware |
0 |
1642523 |
0 |
1983513 |
1983513 |
4.2 % |
04/02/2022 |
Artisan Investments GP LLC |
Delaware |
0 |
1642523 |
0 |
1983513 |
1983513 |
4.2 % |
04/02/2022 |
Artisan Partners Holdings LP |
Delaware |
0 |
1642523 |
0 |
1983513 |
1983513 |
4.2 % |
04/02/2022 |
Artisan Partners Limited Partnership |
Delaware |
0 |
1642523 |
0 |
1983513 |
1983513 |
4.2 % |
04/02/2022 |
Artisan Partners Asset Management Inc. |
Delaware |
0 |
1642523 |
0 |
1983513 |
1983513 |
4.2 % |
04/02/2022 |
Artisan Partners Limited Partnership |
Delaware |
0 |
1642523 |
0 |
1983513 |
1983513 |
4.2 % |
04/02/2022 |
Artisan Partners Asset Management Inc. |
Delaware |
0 |
1642523 |
0 |
1983513 |
1983513 |
4.2 % |
04/02/2022 |
BlackRock, Inc. |
Delaware |
7366520 |
0 |
7423702 |
0 |
7423702 |
15.8 % |
28/01/2022 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
4403840 |
0 |
4923297 |
4923297 |
10.5 % |
10/01/2022 |
Wellington Management Company LLP |
Delaware |
0 |
4392321 |
0 |
4771547 |
4771547 |
10.18 % |
10/01/2022 |
Wellington Management Group LLP |
Massachusetts |
0 |
4403840 |
0 |
4923297 |
4923297 |
10.5 % |
10/01/2022 |
Wellington Group Holdings LLP |
Delaware |
0 |
4403840 |
0 |
4923297 |
4923297 |
10.5 % |
10/01/2022 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
4403840 |
0 |
4923297 |
4923297 |
10.5 % |
10/01/2022 |
Wellington Management Company LLP |
Delaware |
0 |
4392321 |
0 |
4771547 |
4771547 |
10.18 % |
10/01/2022 |
Wellington Management Group LLP |
Massachusetts |
0 |
4403840 |
0 |
4923297 |
4923297 |
10.5 % |
10/01/2022 |
Wellington Group Holdings LLP |
Delaware |
0 |
4403840 |
0 |
4923297 |
4923297 |
10.5 % |
10/01/2022 |
Baillie Gifford & Co |
SCOTLAND UK |
|
0 |
2020325 |
0 |
2020325 |
4.34 % |
05/10/2021 |
Baillie Gifford & Co |
SCOTLAND UK |
|
0 |
2020325 |
0 |
2020325 |
4.34 % |
05/10/2021 |
The Brown Capital Management Small Company Fund |
|
|
|
|
|
2365098 |
5.08 % |
10/09/2021 |
Brown Capital Management, LLC |
|
|
|
|
|
4133820 |
8.88 % |
10/09/2021 |
The Brown Capital Management Small Company Fund |
|
|
|
|
|
2365098 |
5.08 % |
10/09/2021 |
Brown Capital Management, LLC |
|
|
|
|
|
4133820 |
8.88 % |
10/09/2021 |
Thomas W. Burns |
USA |
2483064 |
100000 |
2483064 |
100000 |
2583064 |
5.53 % |
12/02/2021 |
Brown Capital Management, LLC |
Maryland |
4277987 |
0 |
6509274 |
0 |
6509274 |
14.48 % |
12/02/2021 |
The Brown Capital Management Small Company Fund |
Delaware |
3596938 |
0 |
3596938 |
0 |
3596938 |
8 % |
12/02/2021 |
Artisan Partners Limited Partnership |
Delaware |
0 |
1989070 |
0 |
2365390 |
2365390 |
5.3 % |
10/02/2021 |
Artisan Investments GP LLC |
Delaware |
0 |
1989070 |
0 |
2365390 |
2365390 |
5.3 % |
10/02/2021 |
Artisan Partners Asset Management Inc. |
Delaware |
0 |
1989070 |
0 |
2365390 |
2365390 |
5.3 % |
10/02/2021 |
Artisan Partners Holdings LP |
Delaware |
0 |
1989070 |
0 |
2365390 |
2365390 |
5.3 % |
10/02/2021 |
Artisan Partners Holdings LP |
Delaware |
0 |
1989070 |
0 |
2365390 |
2365390 |
5.3 % |
10/02/2021 |
Artisan Partners Asset Management Inc. |
Delaware |
0 |
1989070 |
0 |
2365390 |
2365390 |
5.3 % |
10/02/2021 |
Artisan Partners Limited Partnership |
Delaware |
0 |
1989070 |
0 |
2365390 |
2365390 |
5.3 % |
10/02/2021 |
Artisan Investments GP LLC |
Delaware |
0 |
1989070 |
0 |
2365390 |
2365390 |
5.3 % |
10/02/2021 |
BlackRock, Inc. |
Delaware |
6928071 |
0 |
6987899 |
0 |
6987899 |
15.5 % |
05/02/2021 |
The Vanguard Group |
Pennsylvania |
0 |
97796 |
4381423 |
131604 |
4513027 |
10.04 % |
08/01/2021 |
The Vanguard Group |
Pennsylvania |
0 |
97796 |
4381423 |
131604 |
4513027 |
10.04 % |
08/01/2021 |
Baillie Gifford & Co |
SCOTLAND UK |
|
0 |
4864524 |
0 |
4864524 |
10.82 % |
07/01/2021 |
Baillie Gifford & Co |
SCOTLAND UK |
|
0 |
4864524 |
0 |
4864524 |
10.82 % |
07/01/2021 |
Alger Group Holdings, LLC |
Delaware |
2019383 |
0 |
2019383 |
0 |
2019383 |
4.57 % |
08/05/2020 |
Alger Group Holdings, LLC |
Delaware |
2019383 |
0 |
2019383 |
0 |
2019383 |
4.57 % |
08/05/2020 |
Alger Associates, Inc. |
New York |
2019383 |
0 |
2019383 |
0 |
2019383 |
4.57 % |
08/05/2020 |
Alger Associates, Inc. |
New York |
2019383 |
0 |
2019383 |
0 |
2019383 |
4.57 % |
08/05/2020 |
BlackRock, Inc. |
Delaware |
5777376 |
0 |
5841785 |
0 |
5841785 |
13.4 % |
09/04/2020 |
Thomas W. Burns |
|
|
|
|
|
2631743 |
5.82 % |
14/02/2020 |
Capital World Investors |
Delaware |
1150322 |
0 |
1150322 |
0 |
1150322 |
2.6 % |
14/02/2020 |
Janus Henderson Group plc EIN #000000000 |
Jersey Channel Islands |
0 |
1725973 |
0 |
1725973 |
1725973 |
4.7 % |
14/02/2020 |
Alger Group Holdings, LLC |
Delaware |
2235423 |
0 |
2235423 |
|
2235423 |
5.16 % |
14/02/2020 |
Alger Group Holdings, LLC |
Delaware |
2235423 |
0 |
2235423 |
|
2235423 |
5.16 % |
14/02/2020 |
Alger Associates, Inc. |
New York |
2235423 |
0 |
2235423 |
|
223543 |
5.16 % |
14/02/2020 |
Alger Associates, Inc. |
New York |
2235423 |
0 |
2235423 |
|
223543 |
5.16 % |
14/02/2020 |
Capital Management, LLC |
|
|
|
|
|
4565966 |
10.54 % |
14/02/2020 |
Brown Capital Management Small Company Fund |
|
|
|
|
|
2460624 |
5.68 % |
14/02/2020 |
The Vanguard Group |
Pennsylvania |
81729 |
5115 |
3661786 |
81922 |
3743708 |
8.64 % |
12/02/2020 |
William Blair Investment Management, LLC |
Delaware |
1815770 |
0 |
1976525 |
0 |
1976525 |
4.6 % |
10/02/2020 |
William Blair Investment Management, LLC |
Delaware |
1815770 |
0 |
1976525 |
0 |
1976525 |
4.6 % |
10/02/2020 |
FMR LLC |
Delaware |
770511 |
0 |
1081013 |
0 |
1081013 |
2.495 % |
07/02/2020 |
Abigail P. Johnson |
United States of America |
0 |
0 |
1081013 |
0 |
1081013 |
2.495 % |
07/02/2020 |
FMR LLC |
Delaware |
770511 |
0 |
1081013 |
0 |
1081013 |
2.495 % |
07/02/2020 |
Abigail P. Johnson |
United States of America |
0 |
0 |
1081013 |
0 |
1081013 |
2.495 % |
07/02/2020 |
BlackRock, Inc. |
Delaware |
2847020 |
0 |
2919762 |
0 |
2919762 |
7.9 % |
05/02/2020 |
Baillie Gifford & Co |
SCOTLAND UK |
|
0 |
3577069 |
0 |
3577069 |
8.26 % |
22/01/2020 |
Brown Capital Management, LLC |
State of Maryland |
2678056 |
0 |
4278454 |
0 |
4278454 |
11.62 % |
09/09/2019 |
The Brown Capital Management Small Company Fund |
State of Delaware |
2223181 |
0 |
2223181 |
0 |
2223181 |
6.04 % |
09/09/2019 |
Brown Capital Management, LLC |
State of Maryland |
2678056 |
0 |
4278454 |
0 |
4278454 |
11.62 % |
09/09/2019 |
The Brown Capital Management Small Company Fund |
State of Delaware |
2223181 |
0 |
2223181 |
0 |
2223181 |
6.04 % |
09/09/2019 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
248172 |
0 |
1260077 |
0 |
1260077 |
3.4 % |
14/02/2019 |
Lord, Abbett & Co. LLC |
Delaware |
2053541 |
0 |
2021348 |
0 |
2106080 |
5.85 % |
14/02/2019 |
Lord, Abbett & Co. LLC |
Delaware |
2053541 |
0 |
2021348 |
0 |
2106080 |
5.85 % |
14/02/2019 |
Thomas W. Burns |
|
|
|
|
|
2319915 |
6.17 % |
13/02/2019 |
Capital World Investors |
Delaware |
2820000 |
0 |
2820000 |
0 |
2820000 |
7.8 % |
13/02/2019 |
Capital World Investors |
Delaware |
2820000 |
0 |
2820000 |
0 |
2820000 |
7.8 % |
13/02/2019 |
William Blair Investment Management, LLC |
Delaware |
2301194 |
0 |
2461137 |
0 |
2461137 |
6.8 % |
13/02/2019 |
William Blair Investment Management, LLC |
Delaware |
2301194 |
0 |
2461137 |
0 |
2461137 |
6.8 % |
13/02/2019 |
S Deerfield International Master Fund, L.P. |
British Virgin Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
12/02/2019 |
S James E. Flynn |
United States |
0 |
504000 |
0 |
504000 |
504000 |
1.4 % |
12/02/2019 |
S Deerfield Mgmt, L.P. |
Delaware |
0 |
504000 |
0 |
504000 |
504000 |
1.4 % |
12/02/2019 |
S Deerfield Partners, L.P. |
Delaware |
0 |
504000 |
0 |
504000 |
504000 |
1.4 % |
12/02/2019 |
S Deerfield Management Company, L.P. |
Delaware |
0 |
504000 |
0 |
504000 |
504000 |
1.4 % |
12/02/2019 |
S Deerfield International Master Fund, L.P. |
British Virgin Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
12/02/2019 |
S Deerfield Mgmt, L.P. |
Delaware |
0 |
504000 |
0 |
504000 |
504000 |
1.4 % |
12/02/2019 |
S James E. Flynn |
United States |
0 |
504000 |
0 |
504000 |
504000 |
1.4 % |
12/02/2019 |
S Deerfield Partners, L.P. |
Delaware |
0 |
504000 |
0 |
504000 |
504000 |
1.4 % |
12/02/2019 |
S Deerfield Management Company, L.P. |
Delaware |
0 |
504000 |
0 |
504000 |
504000 |
1.4 % |
12/02/2019 |
Janus Henderson Group plc EIN #000000000 |
Jersey Channel Islands |
0 |
2115992 |
0 |
2115992 |
2115992 |
5.9 % |
12/02/2019 |
The Vanguard Group |
Pennsylvania |
70199 |
4207 |
3431018 |
71312 |
3502330 |
9.72 % |
11/02/2019 |
BlackRock, Inc. |
Delaware |
2485478 |
0 |
2563895 |
0 |
2563895 |
7.1 % |
04/02/2019 |
Brown Capital Management, LLC |
State of Maryland |
1458588 |
0 |
2314255 |
0 |
2314255 |
6.42 % |
10/01/2019 |
Brown Capital Management, LLC |
State of Maryland |
1458588 |
0 |
2314255 |
0 |
2314255 |
6.42 % |
10/01/2019 |
Janus Henderson Group plc EIN |
Jersey, Channel Islands |
0 |
3137873 |
0 |
3137873 |
3137873 |
8.9 % |
10/10/2018 |
Michael B. Gordon |
US |
12800 |
822307 |
12800 |
822307 |
9 |
2.4 % |
14/02/2018 |
George H. Bischof |
US |
2664 |
822307 |
2664 |
822307 |
9 |
2.4 % |
14/02/2018 |
Meritech Capital Partners III L.P. |
Delaware |
807587 |
0 |
807587 |
0 |
9 |
2.3 % |
14/02/2018 |
Paul S. Madera |
US |
40640 |
822307 |
40640 |
822307 |
9 |
2.5 % |
14/02/2018 |
Robert D. Ward |
US |
13547 |
822307 |
13547 |
822307 |
9 |
2.4 % |
14/02/2018 |
Meritech Capital Affiliates III L.P. |
Delaware |
14720 |
0 |
14720 |
0 |
9 |
0.1 % |
14/02/2018 |
Meritech Capital Associates III L.L.C. |
Delaware |
822307 |
5 |
822307 |
0 |
9 |
2.4 % |
14/02/2018 |
Meritech Management Associates III L.L.C. |
Delaware |
822307 |
5 |
822307 |
0 |
9 |
2.4 % |
14/02/2018 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
440209 |
0 |
2469338 |
0 |
2469338 |
7.1 % |
14/02/2018 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
440209 |
0 |
2469338 |
0 |
2469338 |
7.1 % |
14/02/2018 |
Deerfield Management Company, L.P. |
Delaware |
0 |
3343045 |
0 |
3343045 |
3343045 |
9.67 % |
14/02/2018 |
S James E. Flynn |
United States |
0 |
3343045 |
0 |
3343045 |
3343045 |
9.67 % |
14/02/2018 |
S Deerfield International Master Fund, L.P. |
British Virgin Islands |
0 |
1180094 |
0 |
1180094 |
1180094 |
3.41 % |
14/02/2018 |
S Deerfield Partners, L.P. |
Delaware |
0 |
2162951 |
0 |
2162951 |
2162951 |
6.26 % |
14/02/2018 |
S Deerfield Management Company, L.P. |
Delaware |
0 |
3343045 |
0 |
3343045 |
3343045 |
9.67 % |
14/02/2018 |
S Deerfield Mgmt, L.P. |
Delaware |
0 |
3343045 |
0 |
3343045 |
3343045 |
9.67 % |
14/02/2018 |
James E. Flynn |
United States |
0 |
3343045 |
0 |
3343045 |
3343045 |
9.67 % |
14/02/2018 |
Deerfield International Master Fund, L.P. |
British Virgin Islands |
0 |
1180094 |
0 |
1180094 |
1180094 |
3.41 % |
14/02/2018 |
Deerfield Partners, L.P. |
Delaware |
0 |
2162951 |
0 |
2162951 |
2162951 |
6.26 % |
14/02/2018 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
3343045 |
0 |
3343045 |
3343045 |
9.67 % |
14/02/2018 |
Capital World Investors |
Delaware |
2740000 |
0 |
2740000 |
0 |
2740000 |
7.9 % |
13/02/2018 |
Thomas W. Burns |
USA |
2214915 |
100000 |
2214915 |
100000 |
2314915 |
6.4 % |
13/02/2018 |
OrbiMed Capital GP III LLC |
Delaware |
0 |
828608 |
0 |
828608 |
828608 |
2.4 % |
13/02/2018 |
OrbiMed Advisors LLC |
Delaware |
0 |
836500 |
0 |
|
836500 |
2.42 % |
13/02/2018 |
William Blair Investment Management, LLC |
Delaware |
1823102 |
0 |
1966460 |
0 |
1966460 |
5.69 % |
13/02/2018 |
William Blair Investment Management, LLC |
Delaware |
1823102 |
0 |
1966460 |
0 |
1966460 |
5.69 % |
13/02/2018 |
Janus Henderson Group plc EIN #000000000 |
Jersey Channel Islands |
0 |
5098591 |
0 |
5098591 |
5098591 |
14.8 % |
12/02/2018 |
The Vanguard Group |
Pennsylvania |
55571 |
676 |
2333482 |
54623 |
2388105 |
6.9 % |
08/02/2018 |
BlackRock, Inc. |
Delaware |
1902794 |
0 |
1957114 |
0 |
1957114 |
5.7 % |
01/02/2018 |
Janus Henderson Group plc EIN |
Jersey, Channel Islands |
0 |
4068125 |
0 |
4068125 |
4068125 |
11.8 % |
13/11/2017 |
Deerfield Partners, L.P. |
Delaware |
0 |
1490947 |
0 |
1490947 |
1490947 |
4.33 % |
25/09/2017 |
Deerfield Management Company, L.P. |
Delaware |
0 |
2527032 |
0 |
2527032 |
2527032 |
7.34 % |
25/09/2017 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
2527032 |
0 |
2527032 |
2527032 |
7.34 % |
25/09/2017 |
James E. Flynn |
United States |
0 |
2527032 |
0 |
2527032 |
2527032 |
7.34 % |
25/09/2017 |
Deerfield International Master Fund, L.P. |
British Virgin Islands |
0 |
1036085 |
0 |
1036085 |
1036085 |
3.01 % |
25/09/2017 |
Deerfield Partners, L.P. |
Delaware |
0 |
1490947 |
0 |
1490947 |
1490947 |
4.33 % |
25/09/2017 |
Deerfield Management Company, L.P. |
Delaware |
0 |
2527032 |
0 |
2527032 |
2527032 |
7.34 % |
25/09/2017 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
2527032 |
0 |
2527032 |
2527032 |
7.34 % |
25/09/2017 |
James E. Flynn |
United States |
0 |
2527032 |
0 |
2527032 |
2527032 |
7.34 % |
25/09/2017 |
Deerfield International Master Fund, L.P. |
British Virgin Islands |
0 |
1036085 |
0 |
1036085 |
1036085 |
3.01 % |
25/09/2017 |
Versant Affiliates Fund L.P. |
Delaware |
3000 |
0 |
3000 |
0 |
3000 |
0.1 % |
14/02/2017 |
Versant Ventures I, LLC |
Delaware |
0 |
71428 |
0 |
71428 |
71428 |
0.5 % |
14/02/2017 |
Versant Venture Capital I, L.P. |
Delaware |
65714 |
0 |
65714 |
0 |
65714 |
0.2 % |
14/02/2017 |
Versant Side Fund I, L.P. |
Delaware |
1286 |
0 |
1286 |
0 |
1286 |
0.1 % |
14/02/2017 |
William Blair Investment Management, LLC |
W Adams St Chicago IL |
1768422 |
0 |
1959774 |
0 |
1959774 |
5.84 % |
14/02/2017 |
NO. OF ABOVE PERSON InterWest Partners IX, LP |
California |
1018362 |
0 |
1018362 |
0 |
1018362 |
3 % |
14/02/2017 |
NO. OF ABOVE PERSON Khaled A. Nasr |
United States |
0 |
1018362 |
0 |
1018362 |
1018362 |
3 % |
14/02/2017 |
NO. OF ABOVE PERSON Arnold L. Oronsky |
United States |
2778 |
1018362 |
2778 |
1018362 |
1021140 |
3 % |
14/02/2017 |
NO. OF ABOVE PERSON InterWest Management Partners IX, LLC |
California |
1018362 |
0 |
1018362 |
0 |
1018362 |
3 % |
14/02/2017 |
NO. OF ABOVE PERSON W. Stephen Holmes III |
United States |
694 |
1018362 |
694 |
1018362 |
1019056 |
3 % |
14/02/2017 |
NO. OF ABOVE PERSON Philip T. Gianos |
United States |
2147 |
1018362 |
2147 |
1018362 |
1020509 |
3 % |
14/02/2017 |
NO. OF ABOVE PERSON Gilbert H. Kliman |
United States |
17083 |
1018362 |
17083 |
1018362 |
1035445 |
3.1 % |
14/02/2017 |
Capital World Investors |
Delaware |
1945000 |
0 |
1945000 |
0 |
1945000 |
5.7 % |
13/02/2017 |
Capital World Investors |
Delaware |
1945000 |
0 |
1945000 |
0 |
1945000 |
5.7 % |
13/02/2017 |
Thomas W. Burns |
|
|
|
|
|
2347537 |
6.9 % |
13/02/2017 |
Samuel D. Isaly |
United States |
0 |
2180000 |
0 |
2180000 |
2180000 |
6.5 % |
13/02/2017 |
OrbiMed Capital GP III LLC |
Delaware |
0 |
2159430 |
0 |
2159430 |
2159430 |
6.44 % |
13/02/2017 |
OrbiMed Advisors LLC |
Delaware |
0 |
2180000 |
0 |
0 |
2180000 |
6.5 % |
13/02/2017 |
Samuel D. Isaly |
United States |
0 |
2180000 |
0 |
2180000 |
2180000 |
6.5 % |
13/02/2017 |
OrbiMed Capital GP III LLC |
Delaware |
0 |
2159430 |
0 |
2159430 |
2159430 |
6.44 % |
13/02/2017 |
OrbiMed Advisors LLC |
Delaware |
0 |
2180000 |
0 |
0 |
2180000 |
6.5 % |
13/02/2017 |
Montreux Equity Management IV, LLC |
California |
0 |
0 |
0 |
0 |
0 |
0 % |
31/01/2017 |
Montreux IV Associates, L.L.C. |
California |
0 |
0 |
0 |
0 |
0 |
0 % |
31/01/2017 |
Montreux Equity Partners IV, L.P. |
California |
0 |
0 |
0 |
0 |
0 |
0 % |
31/01/2017 |
Montreux Equity Management IV, LLC |
California |
0 |
3279812 |
0 |
3279812 |
3279812 |
10.22 % |
22/02/2016 |
Montreux IV Associates, L.L.C. |
California |
0 |
161406 |
0 |
161406 |
161406 |
0.5 % |
22/02/2016 |
Montreux Equity Partners IV, L.P. |
California |
0 |
3118406 |
0 |
3118406 |
3118406 |
9.71 % |
22/02/2016 |
FHM V, L.L.C. |
Delaware |
0 |
2603362 |
0 |
2603362 |
2603362 |
8.11 % |
16/02/2016 |
FHM V, L.P. |
Delaware |
0 |
2603362 |
0 |
2603362 |
2603362 |
8.11 % |
16/02/2016 |
Frazier Healthcare V, L.P. |
Delaware |
0 |
2603362 |
0 |
2603362 |
2603362 |
8.11 % |
16/02/2016 |
Nathan Every |
United States Citizen |
0 |
2603362 |
0 |
2603362 |
2603362 |
8.11 % |
16/02/2016 |
James Topper |
United States Citizen |
0 |
2603362 |
0 |
2603362 |
2603362 |
8.11 % |
16/02/2016 |
Patrick Heron |
United States Citizen |
0 |
2603362 |
0 |
2603362 |
2603362 |
8.11 % |
16/02/2016 |
Nader Naini |
United States Citizen |
0 |
2603362 |
0 |
2603362 |
2603362 |
8.11 % |
16/02/2016 |
Alan Frazier |
United States Citizen |
0 |
2603362 |
0 |
2603362 |
2603362 |
8.11 % |
16/02/2016 |
Thomas W. Burns |
|
|
|
|
|
2854056 |
8.4 % |
16/02/2016 |
Meritech Capital Partners III L.P. |
Delaware |
2972501 |
2972501 |
2972501 |
2972501 |
2972501 |
9.2 % |
16/02/2016 |
Meritech Capital Associates III L.L.C. |
Delaware |
3026677 |
3026677 |
3026677 |
3026677 |
3026677 |
9.4 % |
16/02/2016 |
Meritech Capital Affiliates III L.P. |
Delaware |
54176 |
54176 |
54176 |
54176 |
54176 |
0.2 % |
16/02/2016 |
George H. Bischof |
U.S. Citizen |
0 |
3026677 |
0 |
3026677 |
3026677 |
9.4 % |
16/02/2016 |
Paul S. Madera |
U.S. Citizen |
0 |
3026677 |
0 |
3026677 |
3026677 |
9.4 % |
16/02/2016 |
Michael B. Gordon |
U.S. Citizen |
0 |
3026677 |
0 |
3026677 |
3026677 |
9.4 % |
16/02/2016 |
Robert D. Ward |
U.S. Citizen |
0 |
3026677 |
0 |
3026677 |
3026677 |
9.4 % |
16/02/2016 |
Meritech Management Associates III L.L.C. |
Delaware |
3026677 |
3026677 |
3026677 |
3026677 |
3026677 |
9.4 % |
16/02/2016 |
Samuel D. Isaly |
United States |
0 |
2897937 |
0 |
2897937 |
2897937 |
9.03 % |
12/02/2016 |
OrbiMed Capital GP III LLC |
Delaware |
0 |
2870593 |
0 |
2870593 |
2870593 |
8.94 % |
12/02/2016 |
OrbiMed Advisors LLC |
Delaware |
0 |
2897937 |
0 |
0 |
2897937 |
9.03 % |
12/02/2016 |
Gilbert H. Kliman NO. OF ABOVE PERSON |
United States |
3334 |
2603362 |
3334 |
2603362 |
2606696 |
8.1 % |
12/02/2016 |
W. Stephen Holmes III NO. OF ABOVE PERSON |
United States |
0 |
2603362 |
0 |
2603362 |
2603362 |
8.1 % |
12/02/2016 |
Philip T. Gianos NO. OF ABOVE PERSON |
United States |
0 |
2603362 |
0 |
2603362 |
2603362 |
8.1 % |
12/02/2016 |
Bruce A. Cleveland NO. OF ABOVE PERSON |
United States |
0 |
2603362 |
0 |
2603362 |
2603362 |
8.1 % |
12/02/2016 |
Douglas A. Pepper NO. OF ABOVE PERSON |
United States |
0 |
2603362 |
0 |
2603362 |
2603362 |
8.1 % |
12/02/2016 |
InterWest Management Partners IX, LLC NO. OF ABOVE PERSON |
California |
2603362 |
0 |
2603362 |
0 |
2603362 |
8.1 % |
12/02/2016 |
Arnold L. Oronsky NO. OF ABOVE PERSON |
United States |
0 |
2603362 |
0 |
2603362 |
2603362 |
8.1 % |
12/02/2016 |
InterWest Partners IX, LP NO. OF ABOVE PERSON |
California |
2603362 |
0 |
2603362 |
0 |
2603362 |
8.1 % |
12/02/2016 |
Khaled A. Nasr NO. OF ABOVE PERSON |
United States |
0 |
2603362 |
0 |
2603362 |
2603362 |
8.1 % |
12/02/2016 |
Versant Affiliates Fund IB, L.P. |
Delaware United States America |
132483 |
0 |
132483 |
0 |
132483 |
0.4 % |
09/02/2016 |
BARBARA N. LUBASH |
United States America |
0 |
3136232 |
0 |
3136232 |
3136232 |
9.8 % |
09/02/2016 |
REBECCA B. ROBERTSON |
United States America |
0 |
3136232 |
0 |
3136232 |
3136232 |
9.8 % |
09/02/2016 |
DONALD B. MILDER |
United States America |
0 |
3136232 |
0 |
3136232 |
3136232 |
9.8 % |
09/02/2016 |
BRIAN G. ATWOOD |
United States America |
0 |
3136232 |
0 |
3136232 |
3136232 |
9.8 % |
09/02/2016 |
ROSS A. JAFFE, M.D. |
United States America |
0 |
3136232 |
0 |
3136232 |
3136232 |
9.8 % |
09/02/2016 |
SAMUEL D. COLELLA |
United States America |
0 |
3136232 |
0 |
3136232 |
3136232 |
9.8 % |
09/02/2016 |
WILLIAM J. LINK |
United States America |
3334 |
3136232 |
3334 |
3136232 |
3139566 |
9.8 % |
09/02/2016 |
Versant Affiliates Fund IA, L.P. |
Delaware United States America |
62217 |
0 |
62217 |
0 |
62217 |
0.2 % |
09/02/2016 |
Versant Side Fund I, L.P. |
Delaware United States America |
56696 |
0 |
56696 |
0 |
56696 |
0.2 % |
09/02/2016 |
Versant Venture Capital I, L.P. |
Delaware United States America |
2884836 |
0 |
2884836 |
0 |
2884836 |
9 % |
09/02/2016 |
Versant Ventures I, LLC |
Delaware United States America |
0 |
3136232 |
0 |
3136232 |
3136232 |
9.8 % |
09/02/2016 |
(Voluntary) Domain Partners VIII, L.P. |
Delaware |
876083 |
0 |
876083 |
0 |
876083 |
2.7 % |
19/01/2016 |
(Voluntary) DP VIII Associates, L.P. |
Delaware |
6501 |
0 |
6501 |
0 |
6501 |
0.1 % |
19/01/2016 |
(Voluntary) Domain Partners IV, L.P. |
Delaware |
2068960 |
0 |
2068960 |
0 |
2068960 |
6.4 % |
19/01/2016 |
(Voluntary) DP IV Associates, L.P. |
Delaware |
14041 |
0 |
14041 |
0 |
14041 |
0.1 % |
19/01/2016 |
(Voluntary) Domain Associates, LLC |
Delaware |
63200 |
0 |
63200 |
0 |
63200 |
0.2 % |
19/01/2016 |
(Voluntary) Domain Partners VIII, L.P. |
Delaware |
876083 |
0 |
876083 |
0 |
876083 |
2.7 % |
19/01/2016 |
(Voluntary) DP VIII Associates, L.P. |
Delaware |
6501 |
0 |
6501 |
0 |
6501 |
0.1 % |
19/01/2016 |
(Voluntary) Domain Partners IV, L.P. |
Delaware |
2068960 |
0 |
2068960 |
0 |
2068960 |
6.4 % |
19/01/2016 |
(Voluntary) DP IV Associates, L.P. |
Delaware |
14041 |
0 |
14041 |
0 |
14041 |
0.1 % |
19/01/2016 |
(Voluntary) Domain Associates, LLC |
Delaware |
63200 |
0 |
63200 |
0 |
63200 |
0.2 % |
19/01/2016 |