| Abigail P. Johnson |
United States of America |
0 |
0 |
4996960 |
0 |
4996960 |
10.224 % |
11/12/2023 |
| FMR LLC |
United States of America |
4995175 |
0 |
4996960 |
0 |
4996960 |
10.224 % |
11/12/2023 |
| (1) BlackRock, Inc. |
Delaware |
7726239 |
0 |
7783794 |
0 |
7783794 |
16.3 % |
31/01/2023 |
| The Vanguard Group - 23-1945930 |
Pennsylvania For |
0 |
86732 |
4989144 |
127451 |
5116595 |
10.91 % |
10/02/2022 |
| Artisan Partners Limited Partnership |
Delaware |
0 |
1642523 |
0 |
1983513 |
1983513 |
4.2 % |
04/02/2022 |
| (1) BlackRock, Inc. |
Delaware |
7366520 |
0 |
7423702 |
0 |
7423702 |
15.8 % |
28/01/2022 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
4403840 |
0 |
0 |
4923297 |
10.5 % |
10/01/2022 |
| Wellington Management Company LLP |
Delaware |
0 |
4392321 |
0 |
0 |
4771547 |
10.18 % |
10/01/2022 |
| Wellington Management Group LLP |
Delaware |
0 |
4403840 |
0 |
0 |
4923297 |
10.5 % |
10/01/2022 |
| Wellington Group Holdings LLP |
Delaware |
0 |
4403840 |
0 |
0 |
4923297 |
10.5 % |
10/01/2022 |
| Artisan Investments GP LLC |
Delaware |
0 |
1989070 |
0 |
2365390 |
2365390 |
5.3 % |
10/02/2021 |
| Artisan Partners Limited Partnership |
Delaware |
0 |
1989070 |
0 |
2365390 |
2365390 |
5.3 % |
10/02/2021 |
| Artisan Partners Asset Management Inc. |
Delaware |
0 |
1989070 |
0 |
2365390 |
2365390 |
5.3 % |
10/02/2021 |
| Artisan Partners Holdings LP |
Delaware |
0 |
1989070 |
0 |
2365390 |
2365390 |
5.3 % |
10/02/2021 |
| (1) BlackRock, Inc. |
Delaware |
5777376 |
0 |
5841785 |
0 |
5841785 |
13.4 % |
09/04/2020 |
| Thomas W. Burns |
USA |
2531743 |
100000 |
2531743 |
0 |
2631743 |
5.82 % |
14/02/2020 |
| Alger Associates, Inc. 13-3017981 |
Delaware |
2235423 |
0 |
2235423 |
0 |
223543 |
5.16 % |
14/02/2020 |
| Alger Group Holdings, LLC |
Delaware |
2235423 |
0 |
2235423 |
0 |
2235423 |
5.16 % |
14/02/2020 |
| Baillie Gifford & Co (Scottish partnership) |
SCOTLAND UK |
0 |
0 |
0 |
0 |
3577069 |
11 % |
22/01/2020 |
| Lord, Abbett & Co. LLC |
Delaware |
2053541 |
0 |
2021348 |
0 |
2106080 |
5.85 % |
14/02/2019 |
| FMR LLC |
Delaware |
916134 |
0 |
2280178 |
0 |
2280178 |
6.328 % |
13/02/2019 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
2280178 |
0 |
2280178 |
6.328 % |
13/02/2019 |
| Brown Capital Management, LLC |
State of Maryland |
1458588 |
0 |
2314255 |
0 |
2314255 |
6.42 % |
10/01/2019 |
| 52-0556948 |
Maryland |
440209 |
0 |
2469338 |
0 |
2469338 |
7.1 % |
14/02/2018 |
| Vanguard Group - 23-1945930 |
Pennsylvania |
55571 |
676 |
2333482 |
54623 |
2388105 |
6.9 % |
08/02/2018 |
| (1) BlackRock, Inc. |
Delaware |
1902794 |
0 |
1957114 |
0 |
1957114 |
5.7 % |
01/02/2018 |
| Partners, L.P. |
Delaware |
0 |
1490947 |
0 |
0 |
1490947 |
4.33 % |
25/09/2017 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
2527032 |
0 |
0 |
2527032 |
7.34 % |
25/09/2017 |
| James E. Flynn |
United States |
0 |
2527032 |
0 |
0 |
2527032 |
7.34 % |
25/09/2017 |
| Fund, L.P. |
British Virgin Islands |
0 |
1036085 |
0 |
0 |
1036085 |
3.01 % |
25/09/2017 |
| Company, L.P. |
Delaware |
0 |
2527032 |
0 |
0 |
2527032 |
7.34 % |
25/09/2017 |
| William Blair Investment Management, LLC |
W Adams St Chicago IL |
1768422 |
0 |
1959774 |
0 |
1959774 |
5.84 % |
14/02/2017 |
| George
H. Bischof (“Bischof”) |
U.S. Citizen |
2664 |
2098624 |
2664 |
0 |
2101288 |
6.3 % |
13/02/2017 |
| Michael B. Gordon (“Gordon”) |
U.S. Citizen |
27094 |
2098624 |
27094 |
0 |
2125718 |
6.3 % |
13/02/2017 |
| Robert
D. Ward (“Ward”) |
U.S. Citizen |
13547 |
2098624 |
13547 |
0 |
2112171 |
6.3 % |
13/02/2017 |
| Paul S. Madera (“Madera”) |
U.S. Citizen |
40640 |
2098624 |
40640 |
0 |
2139264 |
6.4 % |
13/02/2017 |
| Meritech Capital Partners III L.P. (“MCP III”) |
Delaware |
2061059 |
0 |
2061059 |
0 |
2061059 |
6.1 % |
13/02/2017 |
| Meritech
Capital Affiliates III L.P. (“MC AFF III”) |
Delaware |
37565 |
0 |
37565 |
0 |
37565 |
0.1 % |
13/02/2017 |
| Meritech Capital Associates III L.L.C. (“MCA III”) |
Delaware |
2098624 |
2098624 |
2098624 |
0 |
2098624 |
6.3 % |
13/02/2017 |
| Meritech
Management Associates III L.L.C. (“MMA III”) |
Delaware |
2098624 |
2098624 |
2098624 |
0 |
2098624 |
6.3 % |
13/02/2017 |
| Montreux Equity Management IV, LLC |
California |
0 |
0 |
0 |
0 |
0 |
0 % |
31/01/2017 |
| Montreux Equity Partners IV, L.P. |
California |
0 |
0 |
0 |
0 |
0 |
0 % |
31/01/2017 |
| Montreux IV Associates, L.L.C. |
California |
0 |
0 |
0 |
0 |
0 |
0 % |
31/01/2017 |
| Montreux Equity Management IV, LLC |
California |
0 |
3279812 |
0 |
0 |
3279812 |
10.22 % |
22/02/2016 |
| Montreux IV Associates, L.L.C. |
California |
0 |
161406 |
0 |
0 |
161406 |
0.5 % |
22/02/2016 |
| Montreux Equity Partners IV, L.P. |
California |
0 |
3118406 |
0 |
0 |
3118406 |
9.71 % |
22/02/2016 |
| 13G |
Delaware |
0 |
2603362 |
0 |
2603362 |
2603362 |
8.11 % |
16/02/2016 |
| 13G |
Delaware |
0 |
2603362 |
0 |
2603362 |
2603362 |
8.11 % |
16/02/2016 |
| 13G |
Delaware |
0 |
2603362 |
0 |
2603362 |
2603362 |
8.11 % |
16/02/2016 |
| 13G |
Delaware |
0 |
2603362 |
0 |
2603362 |
2603362 |
8.11 % |
16/02/2016 |
| 13G |
Delaware |
0 |
2603362 |
0 |
2603362 |
2603362 |
8.11 % |
16/02/2016 |
| 13G |
Delaware |
0 |
2603362 |
0 |
2603362 |
2603362 |
8.11 % |
16/02/2016 |
| 13G |
Delaware |
0 |
2603362 |
0 |
2603362 |
2603362 |
8.11 % |
16/02/2016 |
| 13G |
Delaware |
0 |
2603362 |
0 |
2603362 |
2603362 |
8.11 % |
16/02/2016 |
| Thomas W. Burns |
USA |
2754056 |
100000 |
2754056 |
0 |
2854056 |
8.4 % |
16/02/2016 |
| Robert D. Ward (“Ward”) |
U.S. Citizen |
0 |
3026677 |
0 |
3026677 |
3026677 |
9.4 % |
16/02/2016 |
| Meritech Capital Partners III L.P. (“MCP III”) |
Delaware |
2972501 |
0 |
2972501 |
0 |
2972501 |
9.2 % |
16/02/2016 |
| Meritech Capital Associates III L.L.C. (“MCA III”) |
Delaware |
3026677 |
3026677 |
3026677 |
3026677 |
3026677 |
9.4 % |
16/02/2016 |
| Meritech Management Associates III L.L.C. (“MMA III”) |
Delaware |
3026677 |
3026677 |
3026677 |
3026677 |
3026677 |
9.4 % |
16/02/2016 |
| Michael B. Gordon (“Gordon”) |
U.S. Citizen |
0 |
3026677 |
0 |
3026677 |
3026677 |
9.4 % |
16/02/2016 |
| George H. Bischof (“Bischof”) |
U.S. Citizen |
0 |
3026677 |
0 |
3026677 |
3026677 |
9.4 % |
16/02/2016 |
| Meritech Capital Affiliates III L.P. (“MC AFF III”) |
Delaware |
54176 |
0 |
54176 |
0 |
54176 |
0.2 % |
16/02/2016 |
| Paul S. Madera (“Madera”) |
U.S. Citizen |
0 |
3026677 |
0 |
3026677 |
3026677 |
9.4 % |
16/02/2016 |
| OrbiMed Capital GP III LLC |
Delaware |
0 |
2870593 |
0 |
0 |
2870593 |
8.94 % |
12/02/2016 |
| OrbiMed Advisors LLC |
Delaware |
0 |
2897937 |
0 |
0 |
2897937 |
9.03 % |
12/02/2016 |
| Samuel D. Isaly |
United States |
0 |
2897937 |
0 |
0 |
2897937 |
9.03 % |
12/02/2016 |
| Page 9 of 14 Pages |
California |
0 |
2603362 |
0 |
2603362 |
2603362 |
8.1 % |
12/02/2016 |
| Page 4 of 14 Pages |
California |
0 |
2603362 |
0 |
2603362 |
2603362 |
8.1 % |
12/02/2016 |
| Page 10 of 14 Pages |
California |
0 |
2603362 |
0 |
2603362 |
2603362 |
8.1 % |
12/02/2016 |
| Page 3 of 14 Pages |
California |
2603362 |
0 |
2603362 |
0 |
2603362 |
8.1 % |
12/02/2016 |
| Page 2 of 14 Pages |
California |
2603362 |
0 |
2603362 |
0 |
2603362 |
8.1 % |
12/02/2016 |
| Page 6 of 14 Pages |
California |
0 |
2603362 |
0 |
2603362 |
2603362 |
8.1 % |
12/02/2016 |
| Page 5 of 14 Pages |
California |
0 |
2603362 |
0 |
2603362 |
2603362 |
8.1 % |
12/02/2016 |
| Page 7 of 14 Pages |
California |
3334 |
2603362 |
3334 |
2603362 |
2606696 |
8.1 % |
12/02/2016 |
| Page 8 of 14 Pages |
California |
0 |
2603362 |
0 |
2603362 |
2603362 |
8.1 % |
12/02/2016 |
| Versant Affiliates Fund I-B, L.P. |
Delaware, United States of America |
132483 |
0 |
132483 |
0 |
132483 |
0.4 % |
09/02/2016 |
| WILLIAM J. LINK |
United States of America |
3334 |
3136232 |
3334 |
0 |
3139566 |
9.8 % |
09/02/2016 |
| SAMUEL D. COLELLA |
United States of America |
0 |
3136232 |
0 |
0 |
3136232 |
9.8 % |
09/02/2016 |
| ROSS A. JAFFE, M.D. |
United States of America |
0 |
3136232 |
0 |
0 |
3136232 |
9.8 % |
09/02/2016 |
| DONALD B. MILDER |
United States of America |
0 |
3136232 |
0 |
0 |
3136232 |
9.8 % |
09/02/2016 |
| REBECCA B. ROBERTSON |
United States of America |
0 |
3136232 |
0 |
0 |
3136232 |
9.8 % |
09/02/2016 |
| BARBARA N. LUBASH |
United States of America |
0 |
3136232 |
0 |
0 |
3136232 |
9.8 % |
09/02/2016 |
| BRIAN G. ATWOOD |
United States of America |
0 |
3136232 |
0 |
0 |
3136232 |
9.8 % |
09/02/2016 |
| Versant Affiliates Fund I-A, L.P. |
Delaware, United States of America |
62217 |
0 |
62217 |
0 |
62217 |
0.2 % |
09/02/2016 |
| Versant Side Fund I, L.P. |
Delaware, United States of America |
56696 |
0 |
56696 |
0 |
56696 |
0.2 % |
09/02/2016 |
| Versant Venture Capital I, L.P. |
Delaware, United States of America |
2884836 |
0 |
2884836 |
0 |
2884836 |
9 % |
09/02/2016 |
| Versant Ventures I, LLC |
Delaware, United States of America |
0 |
3136232 |
0 |
0 |
3136232 |
9.8 % |
09/02/2016 |
| Domain Partners VIII, L.P. |
Delaware |
876083 |
0 |
876083 |
0 |
876083 |
2.7 % |
19/01/2016 |
| Domain Associates, LLC |
Delaware |
63200 |
0 |
63200 |
0 |
63200 |
0.2 % |
19/01/2016 |
| DP IV Associates, L.P. |
Delaware |
14041 |
0 |
14041 |
0 |
14041 |
0.1 % |
19/01/2016 |
| DP VIII Associates, L.P. |
Delaware |
6501 |
0 |
6501 |
0 |
6501 |
0.1 % |
19/01/2016 |
| Domain Partners IV, L.P. |
Delaware |
2068960 |
0 |
2068960 |
0 |
2068960 |
6.4 % |
19/01/2016 |