| Peter Kolchinsky |
Delaware |
0 |
4368998 |
0 |
0 |
4368998 |
5.6 % |
05/12/2024 |
| RA Capital Management, L.P. |
Delaware |
0 |
4368998 |
0 |
0 |
4368998 |
5.6 % |
05/12/2024 |
| Rajeev Shah |
Delaware |
0 |
4368998 |
0 |
0 |
4368998 |
5.6 % |
05/12/2024 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
4368998 |
0 |
0 |
4368998 |
5.6 % |
05/12/2024 |
| Paradigm BioCapital Advisors LP |
Delaware |
3861318 |
0 |
3861318 |
0 |
3861318 |
5.1 % |
02/05/2024 |
| James E. Flynn |
Delaware |
0 |
4374044 |
0 |
0 |
4374044 |
5.89 % |
21/09/2023 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
4374044 |
0 |
0 |
4374044 |
5.89 % |
21/09/2023 |
| Deerfield Partners, L.P. |
Delaware |
0 |
4374044 |
0 |
0 |
4374044 |
5.89 % |
21/09/2023 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
4374044 |
0 |
0 |
4374044 |
5.89 % |
21/09/2023 |
| BVF I GP LLC |
Delaware |
0 |
0 |
0 |
1825402 |
1825402 |
2.7 % |
05/12/2022 |
| BVF Inc. |
Delaware |
0 |
0 |
0 |
3547083 |
3547083 |
5.3 % |
05/12/2022 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
1825402 |
1825402 |
2.7 % |
05/12/2022 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
1502457 |
1502457 |
2.3 % |
05/12/2022 |
| BVF Partners OS Ltd. |
Delaware |
0 |
0 |
0 |
161421 |
161421 |
1 % |
05/12/2022 |
| BVF GP Holdings LLC |
Delaware |
0 |
0 |
0 |
3327859 |
3327859 |
5 % |
05/12/2022 |
| BVF Partners L.P. |
Delaware |
0 |
0 |
0 |
3547083 |
3547083 |
5.3 % |
05/12/2022 |
| Mark N. Lampert |
Delaware |
0 |
0 |
0 |
3547083 |
3547083 |
5.3 % |
05/12/2022 |
| Biotechnology Value Trading Fund OS LP |
Delaware |
0 |
0 |
0 |
161421 |
161421 |
1 % |
05/12/2022 |
| BVF II GP LLC |
Delaware |
0 |
0 |
0 |
1502457 |
1502457 |
2.3 % |
05/12/2022 |
| Averill Master Fund, Ltd. |
|
0 |
3572419 |
0 |
3572419 |
3572419 |
5.4 % |
11/02/2022 |
| Aaron Cowen |
|
0 |
3572419 |
0 |
3572419 |
3572419 |
5.4 % |
11/02/2022 |
| Suvretta Capital Management, LLC |
|
0 |
3572419 |
0 |
3572419 |
3572419 |
5.4 % |
11/02/2022 |
| STATE STREET CORPORATION |
|
0 |
3264508 |
0 |
3378143 |
3378143 |
5.08 % |
11/02/2022 |
| Deep Track Capital, LP |
United States |
0 |
3362000 |
0 |
0 |
3362000 |
5.05 % |
03/02/2022 |
| David Kroin |
United States |
0 |
3362000 |
0 |
0 |
3362000 |
5.05 % |
03/02/2022 |
| Deep Track Biotechnology Master Fund, Ltd. |
United States |
0 |
3362000 |
0 |
0 |
3362000 |
5.05 % |
03/02/2022 |
| EcoR1 Capital, LLC |
Delaware |
0 |
4543447 |
0 |
4543447 |
4543447 |
11 % |
31/01/2022 |
| EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
4134906 |
0 |
4134906 |
4134906 |
11 % |
31/01/2022 |
| Oleg Nodelman |
United States |
0 |
4543447 |
0 |
4543447 |
4543447 |
11 % |
31/01/2022 |
| Averill Master Fund, Ltd. |
Delaware |
0 |
3503419 |
0 |
3503419 |
3503419 |
5.3 % |
09/12/2021 |
| Suvretta Capital Management, LLC |
Delaware |
0 |
3503419 |
0 |
3503419 |
3503419 |
5.3 % |
09/12/2021 |
| Aaron Cowen |
Delaware |
0 |
3503419 |
0 |
3503419 |
3503419 |
5.3 % |
09/12/2021 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
3513756 |
0 |
0 |
3513756 |
5.28 % |
03/12/2021 |
| Company, L.P. |
Delaware |
0 |
3513756 |
0 |
0 |
3513756 |
5.28 % |
03/12/2021 |
| Deerfield Partners, L.P. |
Delaware |
0 |
3513756 |
0 |
0 |
3513756 |
5.28 % |
03/12/2021 |
| James E. Flynn |
Delaware |
0 |
3513756 |
0 |
0 |
3513756 |
5.28 % |
03/12/2021 |
| Behzad Aghazadeh |
United States |
4000000 |
0 |
4000000 |
0 |
4000000 |
6.2 % |
12/02/2021 |
| Avoro Capital Advisors LLC |
Delaware |
4000000 |
0 |
4000000 |
0 |
4000000 |
6.2 % |
12/02/2021 |
| Biotechnology Value Fund, L.P. |
|
0 |
0 |
0 |
662286 |
662286 |
1 % |
11/02/2021 |
| BVF I GP LLC |
|
0 |
0 |
0 |
662286 |
662286 |
1 % |
11/02/2021 |
| BVF II GP LLC |
|
0 |
0 |
0 |
479517 |
479517 |
1 % |
11/02/2021 |
| Biotechnology Value Trading Fund OS LP |
|
0 |
0 |
0 |
80458 |
80458 |
1 % |
11/02/2021 |
| BVF Partners OS Ltd. |
|
0 |
0 |
0 |
80458 |
80458 |
1 % |
11/02/2021 |
| BVF GP HOLDINGS LLC |
|
0 |
0 |
0 |
1141803 |
1141803 |
1.7 % |
11/02/2021 |
| BVF Partners L.P. |
|
0 |
0 |
0 |
1245912 |
1245912 |
1.9 % |
11/02/2021 |
| BVF Inc. |
|
0 |
0 |
0 |
1245912 |
1245912 |
1.9 % |
11/02/2021 |
| Mark N. Lampert |
|
0 |
0 |
0 |
1245912 |
1245912 |
1.9 % |
11/02/2021 |
| Biotechnology Value Fund II, L.P. |
|
0 |
0 |
0 |
479517 |
479517 |
1 % |
11/02/2021 |
| (1) BlackRock, Inc. |
Delaware |
4862467 |
0 |
4931956 |
0 |
4931956 |
7.6 % |
29/01/2021 |
| Troy Edward Wilson |
United States |
570362 |
1620017 |
570362 |
0 |
2190379 |
3.3 % |
28/01/2021 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
934683 |
934683 |
2.1 % |
16/03/2020 |
| BVF I GP LLC |
Delaware |
0 |
0 |
0 |
1254159 |
1254159 |
2.8 % |
16/03/2020 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
1254159 |
1254159 |
2.8 % |
16/03/2020 |
| BVF II GP LLC |
Delaware |
0 |
0 |
0 |
934683 |
934683 |
2.1 % |
16/03/2020 |
| BVF Partners L.P. |
Delaware |
0 |
0 |
0 |
2434696 |
2434696 |
5.4 % |
16/03/2020 |
| BVF Inc. |
Delaware |
0 |
0 |
0 |
2434696 |
2434696 |
5.4 % |
16/03/2020 |
| Mark N. Lampert |
Delaware |
0 |
0 |
0 |
2434696 |
2434696 |
5.4 % |
16/03/2020 |
| Biotechnology Value Trading Fund OS LP |
Delaware |
0 |
0 |
0 |
169021 |
169021 |
1 % |
16/03/2020 |
| BVF Partners OS Ltd. |
Delaware |
0 |
0 |
0 |
169021 |
169021 |
1 % |
16/03/2020 |
| BVF GP HOLDINGS LLC |
Delaware |
0 |
0 |
0 |
2188842 |
2188842 |
4.8 % |
16/03/2020 |
| Mr. David Kroin |
USA |
0 |
853777 |
0 |
0 |
853777 |
1.88 % |
14/02/2020 |
| Great Point Partners, LLC |
USA |
0 |
853777 |
0 |
0 |
853777 |
1.88 % |
14/02/2020 |
| Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
853777 |
0 |
0 |
853777 |
1.88 % |
14/02/2020 |
| Biotechnology Value Fund, L.P. |
|
0 |
0 |
0 |
975568 |
975568 |
2.2 % |
14/02/2020 |
| BVF II GP LLC |
|
0 |
0 |
0 |
817403 |
817403 |
1.8 % |
14/02/2020 |
| BVF Partners OS Ltd. |
|
0 |
0 |
0 |
140716 |
140716 |
1 % |
14/02/2020 |
| BVF GP HOLDINGS LLC |
|
0 |
0 |
0 |
1792971 |
1792971 |
4 % |
14/02/2020 |
| BVF Inc. |
|
0 |
0 |
0 |
1998276 |
1998276 |
4.4 % |
14/02/2020 |
| Mark N. Lampert |
|
0 |
0 |
0 |
1998276 |
1998276 |
4.4 % |
14/02/2020 |
| BVF Partners L.P. |
|
0 |
0 |
0 |
1998276 |
1998276 |
4.4 % |
14/02/2020 |
| Biotechnology Value Trading Fund OS LP |
|
0 |
0 |
0 |
140716 |
140716 |
1 % |
14/02/2020 |
| BVF I GP LLC |
|
0 |
0 |
0 |
975568 |
975568 |
2.2 % |
14/02/2020 |
| Biotechnology Value Fund II, L.P. |
|
0 |
0 |
0 |
817403 |
817403 |
1.8 % |
14/02/2020 |
| EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
3534503 |
0 |
3534503 |
3534503 |
11 % |
14/02/2020 |
| EcoR1 Capital, LLC |
Delaware |
0 |
4241953 |
0 |
4241953 |
4241953 |
11 % |
14/02/2020 |
| Oleg Nodelman |
United States |
0 |
4241953 |
0 |
4241953 |
4241953 |
11 % |
14/02/2020 |
| (1) BlackRock, Inc. |
Delaware |
2935331 |
0 |
2993752 |
0 |
2993752 |
6.6 % |
05/02/2020 |
| 2. |
New York |
2302586 |
0 |
2374586 |
0 |
2374586 |
5.24 % |
31/01/2020 |
| 59-2385219 |
State of Florida |
2064081 |
0 |
2064081 |
0 |
2064081 |
4.55 % |
17/12/2019 |
| FMR LLC |
Delaware |
0 |
0 |
2285510 |
0 |
2285510 |
6.008 % |
13/02/2019 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
2285510 |
0 |
2285510 |
6.008 % |
13/02/2019 |
| Select Biotechnology Portfolio |
Massachusetts |
2285510 |
0 |
0 |
0 |
2285510 |
6.008 % |
13/02/2019 |
| (1) BlackRock, Inc. |
Delaware |
2353589 |
0 |
2409979 |
0 |
2409979 |
6.3 % |
07/02/2019 |
| Troy Edward Wilson |
United States |
667499 |
1768976 |
667499 |
0 |
2436475 |
6.3 % |
30/01/2019 |
| 59-2385219 |
State of Florida |
2034391 |
0 |
2034391 |
0 |
2034391 |
5.35 % |
15/01/2019 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
694536 |
694536 |
1.9 % |
09/07/2018 |
| Mark N. Lampert |
Delaware |
0 |
0 |
0 |
2057346 |
2057346 |
5.5 % |
09/07/2018 |
| BVF Partners OS Ltd. |
Delaware |
0 |
0 |
0 |
157567 |
157567 |
1 % |
09/07/2018 |
| BVF Inc. |
Delaware |
0 |
0 |
0 |
2057346 |
2057346 |
5.5 % |
09/07/2018 |
| BVF Partners L.P. |
Delaware |
0 |
0 |
0 |
2057346 |
2057346 |
5.5 % |
09/07/2018 |
| Biotechnology Value Trading Fund OS LP |
Delaware |
0 |
0 |
0 |
157567 |
157567 |
1 % |
09/07/2018 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
1006657 |
1006657 |
2.7 % |
09/07/2018 |
| (1) BlackRock, Inc. |
Delaware |
1462330 |
0 |
1477318 |
0 |
1477273 |
4.4 % |
08/03/2018 |
| (1) BlackRock, Inc. |
Delaware |
1509081 |
0 |
1524817 |
0 |
1524817 |
5 % |
01/02/2018 |
| Great Point Partners, LLC |
USA |
0 |
1638461 |
0 |
1638461 |
1638461 |
5.92 % |
21/08/2017 |
| Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
1638461 |
0 |
1638461 |
1638461 |
5.92 % |
21/08/2017 |
| Mr. David Kroin |
USA |
0 |
1638461 |
0 |
1638461 |
1638461 |
5.92 % |
21/08/2017 |
| of 5 Pages |
United States |
0 |
21814961 |
0 |
21814961 |
21814961 |
10.2 % |
03/02/2017 |
| Robert Nelsen |
United States of America |
0 |
1888687 |
0 |
0 |
1888687 |
8.8 % |
12/02/2016 |
| ARCH Venture Fund VIII, L.P. |
Delaware |
0 |
1888687 |
0 |
0 |
1888687 |
8.8 % |
12/02/2016 |
| ARCH Venture Partners VIII, LLC |
Delaware |
0 |
1888687 |
0 |
0 |
1888687 |
8.8 % |
12/02/2016 |
| Keith Crandell |
United States of America |
0 |
1888687 |
0 |
0 |
1888687 |
8.8 % |
12/02/2016 |
| Clinton Bybee |
United States of America |
0 |
1888687 |
0 |
0 |
1888687 |
8.8 % |
12/02/2016 |
| ARCH Venture Partners VIII, L.P. |
Delaware |
0 |
1888687 |
0 |
0 |
1888687 |
8.8 % |
12/02/2016 |
| of 5 Pages |
United States |
0 |
0 |
2143727 |
2143727 |
2143727 |
10.03 % |
27/01/2016 |
| 2. |
DELAWARE |
0 |
1076333 |
0 |
1076333 |
1076333 |
5 % |
12/01/2016 |
| 2. |
DELAWARE |
0 |
1076333 |
0 |
1076333 |
1076333 |
5 % |
12/01/2016 |
| 2. |
DELAWARE |
0 |
1076333 |
0 |
1076333 |
1076333 |
5 % |
12/01/2016 |
| 2. |
DELAWARE |
0 |
1076333 |
0 |
1076333 |
1076333 |
5 % |
12/01/2016 |
| 2. |
DELAWARE |
0 |
1076333 |
0 |
1076333 |
1076333 |
5 % |
12/01/2016 |
| FMR LLC |
United States of America |
0 |
0 |
1846519 |
0 |
1846519 |
12.727 % |
10/04/2015 |
| Edward C. Johnson 3d |
United States of America |
0 |
0 |
1846519 |
0 |
1846519 |
12.727 % |
10/04/2015 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
1846519 |
0 |
1846519 |
12.727 % |
10/04/2015 |
| Select Biotechnology Portfolio |
United States of America |
1520587 |
0 |
0 |
0 |
1520587 |
10.48 % |
10/04/2015 |
| BARCLAYS GLOBAL INVESTORS, NA. |
United States |
0 |
1450000 |
0 |
1450000 |
2249431 |
2.24 % |
17/03/2015 |
| ARCH Venture Partners VIII, L.P. |
Delaware |
0 |
1344937 |
0 |
0 |
1344937 |
9.3 % |
13/03/2015 |
| Clinton Bybee |
United States of America |
0 |
1344937 |
0 |
0 |
1344937 |
9.3 % |
13/03/2015 |
| Keith Crandell |
United States of America |
0 |
1344937 |
0 |
0 |
1344937 |
9.3 % |
13/03/2015 |
| ARCH Venture Fund VIII, L.P. |
Delaware |
0 |
1344937 |
0 |
0 |
1344937 |
9.3 % |
13/03/2015 |
| ARCH Venture Partners VIII, LLC |
Delaware |
0 |
1344937 |
0 |
0 |
1344937 |
9.3 % |
13/03/2015 |
| Robert Nelsen |
United States of America |
0 |
1344937 |
0 |
0 |
1344937 |
9.3 % |
13/03/2015 |