Peter Kolchinsky |
United States |
0 |
4368998 |
0 |
4368998 |
4368998 |
5.6 % |
05/12/2024 |
Rajeev Shah |
United States |
0 |
4368998 |
0 |
4368998 |
4368998 |
5.6 % |
05/12/2024 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
4368998 |
0 |
4368998 |
4368998 |
5.6 % |
05/12/2024 |
RA Capital Management, L.P. |
Delaware |
0 |
4368998 |
0 |
4368998 |
4368998 |
5.6 % |
05/12/2024 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
1758630 |
0 |
1758630 |
1758630 |
2.3 % |
14/11/2024 |
BVF II GP LLC |
Delaware |
0 |
1758630 |
0 |
1758630 |
1758630 |
2.3 % |
14/11/2024 |
BVF GP Holdings LLC |
Delaware |
0 |
3943262 |
0 |
3943262 |
3943262 |
5.1 % |
14/11/2024 |
BVF Partners L.P. |
Delaware |
0 |
4212346 |
0 |
4212346 |
4212346 |
5.4 % |
14/11/2024 |
BVF Inc. |
Delaware |
0 |
4212346 |
0 |
4212346 |
4212346 |
5.4 % |
14/11/2024 |
Mark N. Lampert |
United States |
0 |
4212346 |
0 |
4212346 |
4212346 |
5.4 % |
14/11/2024 |
BVF I GP LLC |
Delaware |
0 |
2184632 |
0 |
2184632 |
2184632 |
2.8 % |
14/11/2024 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
2184632 |
0 |
2184632 |
2184632 |
2.8 % |
14/11/2024 |
BVF Partners OS Ltd. |
Cayman Islands |
0 |
192907 |
0 |
192907 |
192907 |
0 % |
14/11/2024 |
Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
192907 |
0 |
192907 |
192907 |
0 % |
14/11/2024 |
Paradigm BioCapital Advisors LP |
Delaware |
4331321 |
0 |
4331321 |
0 |
4331321 |
5.7 % |
14/11/2024 |
Paradigm BioCapital International Fund Ltd. |
Cayman Islands |
3717109 |
0 |
3717109 |
0 |
3717109 |
4.9 % |
14/11/2024 |
Paradigm BioCapital Advisors GP LLC |
Delaware |
4331321 |
0 |
4331321 |
0 |
4331321 |
5.7 % |
14/11/2024 |
Senai Asefaw, M.D. |
United States of America |
4331321 |
0 |
4331321 |
0 |
4331321 |
5.7 % |
14/11/2024 |
EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
7164843 |
0 |
7164843 |
7164843 |
9.4 % |
14/02/2024 |
Oleg Nodelman |
United States |
0 |
7598797 |
0 |
7598797 |
7598797 |
9.99 % |
14/02/2024 |
EcoR1 Capital, LLC |
Delaware |
0 |
7598797 |
0 |
7598797 |
7598797 |
9.99 % |
14/02/2024 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
3801949 |
0 |
3801949 |
3801949 |
5.1 % |
14/02/2024 |
BVF Partners OS Ltd. |
Cayman Islands |
0 |
379147 |
0 |
379147 |
379147 |
0 % |
14/02/2024 |
Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
379147 |
0 |
379147 |
379147 |
0 % |
14/02/2024 |
BVF II GP LLC |
Delaware |
0 |
3081519 |
0 |
3081519 |
3081519 |
4.1 % |
14/02/2024 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
3081519 |
0 |
3081519 |
3081519 |
4.1 % |
14/02/2024 |
BVF I GP LLC |
Delaware |
0 |
3801949 |
0 |
3801949 |
3801949 |
5.1 % |
14/02/2024 |
BVF GP Holdings LLC |
Delaware |
0 |
6883468 |
0 |
6883468 |
6883468 |
9.3 % |
14/02/2024 |
BVF Partners L.P. |
Delaware |
0 |
7373228 |
0 |
7373228 |
7373228 |
9.9 % |
14/02/2024 |
BVF Inc. |
Delaware |
0 |
7373228 |
0 |
7373228 |
7373228 |
9.9 % |
14/02/2024 |
Mark N. Lampert |
United States |
0 |
7373228 |
0 |
7373228 |
7373228 |
9.9 % |
14/02/2024 |
James E. Flynn |
United States |
0 |
5312733 |
0 |
5312733 |
5312733 |
7.15 % |
12/02/2024 |
Deerfield Partners, L.P. |
Delaware |
0 |
5312733 |
0 |
5312733 |
5312733 |
7.15 % |
12/02/2024 |
Deerfield Management Company, L.P. |
Delaware |
0 |
5312733 |
0 |
5312733 |
5312733 |
7.15 % |
12/02/2024 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
5312733 |
0 |
5312733 |
5312733 |
7.15 % |
12/02/2024 |
BlackRock, Inc. |
Delaware |
7052847 |
0 |
7315647 |
0 |
7315647 |
9.8 % |
24/01/2024 |
STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
2752254 |
0 |
2921810 |
2921810 |
3.93 % |
23/01/2024 |
Deerfield Partners, L.P. |
Delaware |
0 |
4374044 |
0 |
4374044 |
4374044 |
5.89 % |
21/09/2023 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
4374044 |
0 |
4374044 |
4374044 |
5.89 % |
21/09/2023 |
Deerfield Management Company, L.P. |
Delaware |
0 |
4374044 |
0 |
4374044 |
4374044 |
5.89 % |
21/09/2023 |
James E. Flynn |
United States |
0 |
4374044 |
0 |
4374044 |
4374044 |
5.89 % |
21/09/2023 |
Deerfield Partners, L.P. |
Delaware |
0 |
4374044 |
0 |
4374044 |
4374044 |
5.89 % |
21/09/2023 |
Deerfield Management Company, L.P. |
Delaware |
0 |
4374044 |
0 |
4374044 |
4374044 |
5.89 % |
21/09/2023 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
4374044 |
0 |
4374044 |
4374044 |
5.89 % |
21/09/2023 |
James E. Flynn |
United States |
0 |
4374044 |
0 |
4374044 |
4374044 |
5.89 % |
21/09/2023 |
The Vanguard Group |
Pennsylvania For |
0 |
43694 |
3338971 |
66198 |
3405169 |
5.09 % |
09/02/2023 |
BVF Partners L.P. |
Delaware |
0 |
3547083 |
0 |
3547083 |
3547083 |
5.3 % |
05/12/2022 |
BVF Inc. |
Delaware |
0 |
3547083 |
0 |
3547083 |
3547083 |
5.3 % |
05/12/2022 |
BVF Partners L.P. |
Delaware |
0 |
3547083 |
0 |
3547083 |
3547083 |
5.3 % |
05/12/2022 |
BVF GP Holdings LLC |
Delaware |
0 |
3327859 |
0 |
3327859 |
3327859 |
5 % |
05/12/2022 |
BVF Partners OS Ltd. |
Cayman Islands |
0 |
161421 |
0 |
161421 |
161421 |
0 % |
05/12/2022 |
Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
161421 |
0 |
161421 |
161421 |
0 % |
05/12/2022 |
BVF II GP LLC |
Delaware |
0 |
1502457 |
0 |
1502457 |
1502457 |
2.3 % |
05/12/2022 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
1502457 |
0 |
1502457 |
1502457 |
2.3 % |
05/12/2022 |
BVF I GP LLC |
Delaware |
0 |
1825402 |
0 |
1825402 |
1825402 |
2.7 % |
05/12/2022 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
1825402 |
0 |
1825402 |
1825402 |
2.7 % |
05/12/2022 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
1825402 |
0 |
1825402 |
1825402 |
2.7 % |
05/12/2022 |
BVF I GP LLC |
Delaware |
0 |
1825402 |
0 |
1825402 |
1825402 |
2.7 % |
05/12/2022 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
1502457 |
0 |
1502457 |
1502457 |
2.3 % |
05/12/2022 |
BVF II GP LLC |
Delaware |
0 |
1502457 |
0 |
1502457 |
1502457 |
2.3 % |
05/12/2022 |
Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
161421 |
0 |
161421 |
161421 |
0 % |
05/12/2022 |
BVF Partners OS Ltd. |
Cayman Islands |
0 |
161421 |
0 |
161421 |
161421 |
0 % |
05/12/2022 |
BVF GP Holdings LLC |
Delaware |
0 |
3327859 |
0 |
3327859 |
3327859 |
5 % |
05/12/2022 |
BVF Inc. |
Delaware |
0 |
3547083 |
0 |
3547083 |
3547083 |
5.3 % |
05/12/2022 |
Mark N. Lampert |
United States |
0 |
3547083 |
0 |
3547083 |
3547083 |
5.3 % |
05/12/2022 |
Mark N. Lampert |
United States |
0 |
3547083 |
0 |
3547083 |
3547083 |
5.3 % |
05/12/2022 |
FMR LLC |
Delaware |
241209 |
0 |
241463 |
0 |
241463 |
0.362 % |
10/03/2022 |
FMR LLC |
Delaware |
241209 |
0 |
241463 |
0 |
241463 |
0.362 % |
10/03/2022 |
Abigail P. Johnson |
United States of America |
0 |
0 |
241463 |
0 |
241463 |
0.362 % |
10/03/2022 |
Abigail P. Johnson |
United States of America |
0 |
0 |
241463 |
0 |
241463 |
0.362 % |
10/03/2022 |
David Kroin |
United States |
0 |
3362000 |
0 |
3362000 |
0 |
5.05 % |
03/02/2022 |
Deep Track Biotechnology Master Fund, Ltd. |
Cayman Islands |
0 |
3362000 |
0 |
3362000 |
0 |
5.05 % |
03/02/2022 |
Deep Track Capital, LP |
Delaware |
0 |
3362000 |
0 |
3362000 |
0 |
5.05 % |
03/02/2022 |
BlackRock, Inc. |
Delaware |
4978743 |
0 |
5095026 |
0 |
5095026 |
7.7 % |
02/02/2022 |
EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
4134906 |
0 |
4134906 |
4134906 |
6.2 % |
31/01/2022 |
EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
4134906 |
0 |
4134906 |
4134906 |
6.2 % |
31/01/2022 |
Oleg Nodelman |
United States |
0 |
4543447 |
0 |
4543447 |
4543447 |
6.8 % |
31/01/2022 |
EcoR1 Capital, LLC |
Delaware |
0 |
4543447 |
0 |
4543447 |
4543447 |
6.8 % |
31/01/2022 |
Oleg Nodelman |
United States |
0 |
4543447 |
0 |
4543447 |
4543447 |
6.8 % |
31/01/2022 |
EcoR1 Capital, LLC |
Delaware |
0 |
4543447 |
0 |
4543447 |
4543447 |
6.8 % |
31/01/2022 |
FMR LLC |
Delaware |
359389 |
0 |
5582200 |
0 |
5582200 |
8.387 % |
10/01/2022 |
Abigail P. Johnson |
United States of America |
0 |
0 |
5582200 |
0 |
5582200 |
8.387 % |
10/01/2022 |
Aaron Cowen |
U.S.A. |
0 |
3503419 |
0 |
3503419 |
3503419 |
5.3 % |
09/12/2021 |
Aaron Cowen |
U.S.A. |
0 |
3503419 |
0 |
3503419 |
3503419 |
5.3 % |
09/12/2021 |
Suvretta Capital Management, LLC |
Delaware |
0 |
3503419 |
0 |
3503419 |
3503419 |
5.3 % |
09/12/2021 |
Suvretta Capital Management, LLC |
Delaware |
0 |
3503419 |
0 |
3503419 |
3503419 |
5.3 % |
09/12/2021 |
Averill Master Fund, Ltd. |
Cayman Islands |
0 |
3503419 |
0 |
3503419 |
3503419 |
5.3 % |
09/12/2021 |
Averill Master Fund, Ltd. |
Cayman Islands |
0 |
3503419 |
0 |
3503419 |
3503419 |
5.3 % |
09/12/2021 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
3513756 |
0 |
3513756 |
3513756 |
5.28 % |
03/12/2021 |
Deerfield Partners, L.P. |
Delaware |
0 |
3513756 |
0 |
3513756 |
3513756 |
5.28 % |
03/12/2021 |
James E. Flynn |
United States |
0 |
3513756 |
0 |
3513756 |
3513756 |
5.28 % |
03/12/2021 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
3513756 |
0 |
3513756 |
3513756 |
5.28 % |
03/12/2021 |
Deerfield Management Company, L.P. |
Delaware |
0 |
3513756 |
0 |
3513756 |
3513756 |
5.28 % |
03/12/2021 |
Deerfield Partners, L.P. |
Delaware |
0 |
3513756 |
0 |
3513756 |
3513756 |
5.28 % |
03/12/2021 |
James E. Flynn |
United States |
0 |
3513756 |
0 |
3513756 |
3513756 |
5.28 % |
03/12/2021 |
Deerfield Management Company, L.P. |
Delaware |
0 |
3513756 |
0 |
3513756 |
3513756 |
5.28 % |
03/12/2021 |
EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
0 |
0 |
0 |
9 |
2.3 % |
16/02/2021 |
Oleg Nodelman |
United States |
0 |
0 |
0 |
0 |
9 |
2.7 % |
16/02/2021 |
EcoR1 Capital, LLC |
Delaware |
0 |
0 |
0 |
0 |
9 |
2.7 % |
16/02/2021 |
EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
0 |
0 |
0 |
9 |
2.3 % |
16/02/2021 |
Oleg Nodelman |
United States |
0 |
0 |
0 |
0 |
9 |
2.7 % |
16/02/2021 |
EcoR1 Capital, LLC |
Delaware |
0 |
0 |
0 |
0 |
9 |
2.7 % |
16/02/2021 |
Victory Capital Management Inc. |
New York |
1782281 |
0 |
1836141 |
0 |
1836141 |
2.78 % |
03/02/2021 |
Victory Capital Management Inc. |
New York |
1782281 |
0 |
1836141 |
0 |
1836141 |
2.78 % |
03/02/2021 |
BlackRock, Inc. |
Delaware |
4862467 |
0 |
4931956 |
0 |
4931956 |
7.6 % |
29/01/2021 |
Troy Edward Wilson |
United States |
5703621 |
1620017 |
5703621 |
1620017 |
21903791 |
3.3 % |
28/01/2021 |
Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
169021 |
0 |
169021 |
169021 |
0 % |
16/03/2020 |
BVF II GP LLC |
Delaware |
0 |
934683 |
0 |
934683 |
934683 |
2.1 % |
16/03/2020 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
934683 |
0 |
934683 |
934683 |
2.1 % |
16/03/2020 |
BVF I GP LLC |
Delaware |
0 |
1254159 |
0 |
1254159 |
1254159 |
2.8 % |
16/03/2020 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
1254159 |
0 |
1254159 |
1254159 |
2.8 % |
16/03/2020 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
1254159 |
0 |
1254159 |
1254159 |
2.8 % |
16/03/2020 |
Mark N. Lampert |
United States |
0 |
2434696 |
0 |
2434696 |
2434696 |
5.4 % |
16/03/2020 |
BVF Inc. |
Delaware |
0 |
2434696 |
0 |
2434696 |
2434696 |
5.4 % |
16/03/2020 |
BVF Partners L.P. |
Delaware |
0 |
2434696 |
0 |
2434696 |
2434696 |
5.4 % |
16/03/2020 |
Mark N. Lampert |
United States |
0 |
2434696 |
0 |
2434696 |
2434696 |
5.4 % |
16/03/2020 |
BVF Inc. |
Delaware |
0 |
2434696 |
0 |
2434696 |
2434696 |
5.4 % |
16/03/2020 |
BVF Partners L.P. |
Delaware |
0 |
2434696 |
0 |
2434696 |
2434696 |
5.4 % |
16/03/2020 |
BVF GP HOLDINGS LLC |
Delaware |
0 |
2188842 |
0 |
2188842 |
2188842 |
4.8 % |
16/03/2020 |
BVF GP HOLDINGS LLC |
Delaware |
0 |
2188842 |
0 |
2188842 |
2188842 |
4.8 % |
16/03/2020 |
BVF Partners OS Ltd. |
Cayman Islands |
0 |
169021 |
0 |
169021 |
169021 |
0 % |
16/03/2020 |
BVF Partners OS Ltd. |
Cayman Islands |
0 |
169021 |
0 |
169021 |
169021 |
0 % |
16/03/2020 |
Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
169021 |
0 |
169021 |
169021 |
0 % |
16/03/2020 |
BVF II GP LLC |
Delaware |
0 |
934683 |
0 |
934683 |
934683 |
2.1 % |
16/03/2020 |
BVF I GP LLC |
Delaware |
0 |
1254159 |
0 |
1254159 |
1254159 |
2.8 % |
16/03/2020 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
934683 |
0 |
934683 |
934683 |
2.1 % |
16/03/2020 |
Mr. David Kroin |
USA |
0 |
853777 |
0 |
853777 |
0 |
1.88 % |
14/02/2020 |
Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
853777 |
0 |
853777 |
0 |
1.88 % |
14/02/2020 |
Mr. David Kroin |
USA |
0 |
853777 |
0 |
853777 |
0 |
1.88 % |
14/02/2020 |
Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
853777 |
0 |
853777 |
0 |
1.88 % |
14/02/2020 |
Great Point Partners, LLC |
USA |
0 |
853777 |
0 |
853777 |
0 |
1.88 % |
14/02/2020 |
Great Point Partners, LLC |
USA |
0 |
853777 |
0 |
853777 |
0 |
1.88 % |
14/02/2020 |
Oleg Nodelman |
United States |
0 |
4241953 |
0 |
4241953 |
4241953 |
9.4 % |
14/02/2020 |
EcoR1 Capital, LLC |
Delaware |
0 |
4241953 |
0 |
4241953 |
4241953 |
9.4 % |
14/02/2020 |
EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
3534503 |
0 |
3534503 |
3534503 |
7.8 % |
14/02/2020 |
FMR LLC |
Delaware |
0 |
0 |
6797202 |
0 |
6797202 |
14.999 % |
07/02/2020 |
Abigail P. Johnson |
United States of America |
0 |
0 |
6797202 |
0 |
6797202 |
14.999 % |
07/02/2020 |
Abigail P. Johnson |
United States of America |
0 |
0 |
6797202 |
0 |
6797202 |
14.999 % |
07/02/2020 |
FMR LLC |
Delaware |
0 |
0 |
6797202 |
0 |
6797202 |
14.999 % |
07/02/2020 |
BlackRock, Inc. |
Delaware |
2935331 |
0 |
2993752 |
0 |
2993752 |
6.6 % |
05/02/2020 |
Troy Edward Wilson |
United States |
8834791 |
1768976 |
8834791 |
1768976 |
26524551 |
5.8 % |
31/01/2020 |
Victory Capital Management Inc. |
New York |
2302586 |
0 |
2374586 |
0 |
2374586 |
5.24 % |
31/01/2020 |
Victory Capital Management Inc. |
New York |
2302586 |
0 |
2374586 |
0 |
2374586 |
5.24 % |
31/01/2020 |
Eagle Asset Management, Inc. |
State of Florida |
|
12 |
2064081 |
|
2064081 |
4.55 % |
17/12/2019 |
Abigail P. Johnson |
United States of America |
0 |
0 |
4870878 |
0 |
4870878 |
10.835 % |
10/07/2019 |
FMR LLC |
Delaware |
0 |
0 |
4870878 |
0 |
4870878 |
10.835 % |
10/07/2019 |
Abigail P. Johnson |
United States of America |
0 |
0 |
4870878 |
0 |
4870878 |
10.835 % |
10/07/2019 |
FMR LLC |
Delaware |
0 |
0 |
4870878 |
0 |
4870878 |
10.835 % |
10/07/2019 |
Mr. David Kroin |
USA |
0 |
2769527 |
0 |
2769527 |
2769527 |
7.28 % |
14/02/2019 |
Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
2769527 |
0 |
2769527 |
2769527 |
7.28 % |
14/02/2019 |
Great Point Partners, LLC |
USA |
0 |
2769527 |
0 |
2769527 |
2769527 |
7.28 % |
14/02/2019 |
Mr. David Kroin |
USA |
0 |
2769527 |
0 |
2769527 |
2769527 |
7.28 % |
14/02/2019 |
Great Point Partners, LLC |
USA |
0 |
2769527 |
0 |
2769527 |
2769527 |
7.28 % |
14/02/2019 |
Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
2769527 |
0 |
2769527 |
2769527 |
7.28 % |
14/02/2019 |
Oleg Nodelman |
United States |
0 |
5276753 |
0 |
5276753 |
5276753 |
13.9 % |
14/02/2019 |
EcoR1 Capital, LLC |
Delaware |
0 |
5276753 |
0 |
5276753 |
5276753 |
13.9 % |
14/02/2019 |
EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
4408097 |
0 |
4408097 |
4408097 |
11.6 % |
14/02/2019 |
EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
4408097 |
0 |
4408097 |
4408097 |
11.6 % |
14/02/2019 |
EcoR1 Capital, LLC |
Delaware |
0 |
5276753 |
0 |
5276753 |
5276753 |
13.9 % |
14/02/2019 |
Oleg Nodelman |
United States |
0 |
5276753 |
0 |
5276753 |
5276753 |
13.9 % |
14/02/2019 |
BlackRock, Inc. |
Delaware |
2353589 |
0 |
2409979 |
0 |
2409979 |
6.3 % |
07/02/2019 |
Troy Edward Wilson |
United States |
6674991 |
1768976 |
6674991 |
1768976 |
24364751 |
6.3 % |
30/01/2019 |
Eagle Asset Management, Inc. |
State of Florida |
2034391 |
12 |
2034391 |
|
2034391 |
5.35 % |
15/01/2019 |
FMR LLC |
Delaware |
0 |
0 |
3366419 |
0 |
3366419 |
9.133 % |
10/07/2018 |
Select Biotechnology Portfolio |
Massachusetts |
2380817 |
0 |
0 |
0 |
2380817 |
6.459 % |
10/07/2018 |
Abigail P. Johnson |
United States of America |
0 |
0 |
3366419 |
0 |
3366419 |
9.133 % |
10/07/2018 |
FMR LLC |
Delaware |
0 |
0 |
3366419 |
0 |
3366419 |
9.133 % |
10/07/2018 |
Abigail P. Johnson |
United States of America |
0 |
0 |
3366419 |
0 |
3366419 |
9.133 % |
10/07/2018 |
Select Biotechnology Portfolio |
Massachusetts |
2380817 |
0 |
0 |
0 |
2380817 |
6.459 % |
10/07/2018 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
1006657 |
0 |
1006657 |
1006657 |
2.7 % |
09/07/2018 |
Mark N. Lampert |
United States |
0 |
2057346 |
0 |
2057346 |
2057346 |
5.5 % |
09/07/2018 |
BVF Inc. |
Delaware |
0 |
2057346 |
0 |
2057346 |
2057346 |
5.5 % |
09/07/2018 |
BVF Partners L.P. |
Delaware |
0 |
2057346 |
0 |
2057346 |
2057346 |
5.5 % |
09/07/2018 |
BVF Partners OS Ltd. |
Cayman Islands |
0 |
157567 |
0 |
157567 |
157567 |
0 % |
09/07/2018 |
Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
157567 |
0 |
157567 |
157567 |
0 % |
09/07/2018 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
694536 |
0 |
694536 |
694536 |
1.9 % |
09/07/2018 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
1006657 |
0 |
1006657 |
1006657 |
2.7 % |
09/07/2018 |
BVF Partners L.P. |
Delaware |
0 |
2057346 |
0 |
2057346 |
2057346 |
5.5 % |
09/07/2018 |
BVF Partners OS Ltd. |
Cayman Islands |
0 |
157567 |
0 |
157567 |
157567 |
0 % |
09/07/2018 |
Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
157567 |
0 |
157567 |
157567 |
0 % |
09/07/2018 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
694536 |
0 |
694536 |
694536 |
1.9 % |
09/07/2018 |
Mark N. Lampert |
United States |
0 |
2057346 |
0 |
2057346 |
2057346 |
5.5 % |
09/07/2018 |
BVF Inc. |
Delaware |
0 |
2057346 |
0 |
2057346 |
2057346 |
5.5 % |
09/07/2018 |
BlackRock, Inc. |
Delaware |
1462330 |
0 |
1477318 |
0 |
1477273 |
4.4 % |
08/03/2018 |
Mr. David Kroin |
USA |
0 |
2197283 |
0 |
2197283 |
2197283 |
7.27 % |
14/02/2018 |
Great Point Partners, LLC |
USA |
0 |
2197283 |
0 |
2197283 |
2197283 |
7.27 % |
14/02/2018 |
Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
2197283 |
0 |
2197283 |
2197283 |
7.27 % |
14/02/2018 |
Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
2197283 |
0 |
2197283 |
2197283 |
7.27 % |
14/02/2018 |
Mr. David Kroin |
USA |
0 |
2197283 |
0 |
2197283 |
2197283 |
7.27 % |
14/02/2018 |
Great Point Partners, LLC |
USA |
0 |
2197283 |
0 |
2197283 |
2197283 |
7.27 % |
14/02/2018 |
Troy Edward Wilson |
United States |
5357551 |
1735991 |
5357551 |
1735991 |
22717461 |
7.5 % |
31/01/2018 |
Select Biotechnology Portfolio |
Massachusetts |
1585186 |
0 |
0 |
0 |
1585186 |
5.246 % |
11/12/2017 |
Abigail P. Johnson |
United States of America |
0 |
0 |
2403208 |
0 |
2403208 |
7.953 % |
11/12/2017 |
Abigail P. Johnson |
United States of America |
0 |
0 |
2403208 |
0 |
2403208 |
7.953 % |
11/12/2017 |
Select Biotechnology Portfolio |
Massachusetts |
1585186 |
0 |
0 |
0 |
1585186 |
5.246 % |
11/12/2017 |
FMR LLC |
Delaware |
0 |
0 |
2403208 |
0 |
2403208 |
7.953 % |
11/12/2017 |
FMR LLC |
Delaware |
0 |
0 |
2403208 |
0 |
2403208 |
7.953 % |
11/12/2017 |
EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
3057191 |
0 |
3057191 |
3057191 |
11 % |
21/08/2017 |
Oleg Nodelman |
United States |
0 |
3766852 |
0 |
3766852 |
3766852 |
13.6 % |
21/08/2017 |
EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
3057191 |
0 |
3057191 |
3057191 |
11 % |
21/08/2017 |
EcoR1 Capital, LLC |
Delaware |
0 |
3766852 |
0 |
3766852 |
3766852 |
13.6 % |
21/08/2017 |
EcoR1 Capital, LLC |
Delaware |
0 |
3766852 |
0 |
3766852 |
3766852 |
13.6 % |
21/08/2017 |
Oleg Nodelman |
United States |
0 |
3766852 |
0 |
3766852 |
3766852 |
13.6 % |
21/08/2017 |
Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
1638461 |
0 |
1638461 |
1638461 |
5.92 % |
21/08/2017 |
Great Point Partners, LLC |
USA |
0 |
1638461 |
0 |
1638461 |
1638461 |
5.92 % |
21/08/2017 |
Mr. David Kroin |
USA |
0 |
1638461 |
0 |
1638461 |
1638461 |
5.92 % |
21/08/2017 |
Great Point Partners, LLC |
USA |
0 |
1638461 |
0 |
1638461 |
1638461 |
5.92 % |
21/08/2017 |
Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
1638461 |
0 |
1638461 |
1638461 |
5.92 % |
21/08/2017 |
Mr. David Kroin |
USA |
0 |
1638461 |
0 |
1638461 |
1638461 |
5.92 % |
21/08/2017 |
FMR LLC |
Delaware |
0 |
0 |
2815919 |
0 |
2815919 |
13.178 % |
14/02/2017 |
Abigail P. Johnson |
United States of America |
0 |
0 |
2815919 |
0 |
2815919 |
13.178 % |
14/02/2017 |
FMR LLC |
Delaware |
0 |
0 |
2815919 |
0 |
2815919 |
13.178 % |
14/02/2017 |
Select Biotechnology Portfolio |
Massachusetts |
1894217 |
0 |
0 |
0 |
1894217 |
8.864 % |
14/02/2017 |
Select Biotechnology Portfolio |
Massachusetts |
1894217 |
0 |
0 |
0 |
1894217 |
8.864 % |
14/02/2017 |
Abigail P. Johnson |
United States of America |
0 |
0 |
2815919 |
0 |
2815919 |
13.178 % |
14/02/2017 |
Troy Edward Wilson |
United States |
|
21814961 |
|
21814961 |
21814961 |
10.2 % |
03/02/2017 |
Partner Fund Management, L.P. |
Delaware |
0 |
1494169 |
0 |
0 |
6 |
7 % |
16/02/2016 |
Brian D. Grossman |
US |
0 |
1542917 |
0 |
0 |
6 |
7.2 % |
16/02/2016 |
Christopher M. James |
US |
0 |
1542917 |
0 |
0 |
6 |
7.2 % |
16/02/2016 |
Christopher M. James |
US |
0 |
1542917 |
0 |
0 |
6 |
7.2 % |
16/02/2016 |
Brian D. Grossman |
US |
0 |
1542917 |
0 |
0 |
6 |
7.2 % |
16/02/2016 |
Partner Investment Management, L.P. |
Delaware |
0 |
48748 |
0 |
0 |
6 |
0.2 % |
16/02/2016 |
Partner Fund Management GP, LLC |
Delaware |
0 |
1494169 |
0 |
0 |
6 |
7 % |
16/02/2016 |
Partner Fund Management, L.P. |
Delaware |
0 |
1494169 |
0 |
0 |
6 |
7 % |
16/02/2016 |
Partner Investment Management GP, LLC |
Delaware |
0 |
48748 |
0 |
0 |
6 |
0.2 % |
16/02/2016 |
Partner Investment Management, L.P. |
Delaware |
0 |
48748 |
0 |
0 |
6 |
0.2 % |
16/02/2016 |
Partner Fund Management GP, LLC |
Delaware |
0 |
1494169 |
0 |
0 |
6 |
7 % |
16/02/2016 |
Partner Investment Management GP, LLC |
Delaware |
0 |
48748 |
0 |
0 |
6 |
0.2 % |
16/02/2016 |
Troy Edward Wilson |
United States |
|
2143727 |
|
2143727 |
2143727 |
10.03 % |
27/01/2016 |
JAMES E. CANTY |
UNITED STATES |
0 |
1076333 |
0 |
1076333 |
1076333 |
5 % |
12/01/2016 |
ERIC A. BROCK |
UNITED STATES |
0 |
1076333 |
0 |
1076333 |
1076333 |
5 % |
12/01/2016 |
CHARLES I. CLOUGH, JR. |
UNITED STATES |
0 |
1076333 |
0 |
1076333 |
1076333 |
5 % |
12/01/2016 |
CLOUGH CAPITAL PARTNERS LLC |
DELAWARE |
0 |
1076333 |
0 |
1076333 |
1076333 |
5 % |
12/01/2016 |
CLOUGH CAPITAL PARTNERS L.P. |
DELAWARE |
0 |
1076333 |
0 |
1076333 |
1076333 |
5 % |
12/01/2016 |
ERIC A. BROCK |
UNITED STATES |
0 |
1076333 |
0 |
1076333 |
1076333 |
5 % |
12/01/2016 |
JAMES E. CANTY |
UNITED STATES |
0 |
1076333 |
0 |
1076333 |
1076333 |
5 % |
12/01/2016 |
CHARLES I. CLOUGH, JR. |
UNITED STATES |
0 |
1076333 |
0 |
1076333 |
1076333 |
5 % |
12/01/2016 |
CLOUGH CAPITAL PARTNERS LLC |
DELAWARE |
0 |
1076333 |
0 |
1076333 |
1076333 |
5 % |
12/01/2016 |
CLOUGH CAPITAL PARTNERS L.P. |
DELAWARE |
0 |
1076333 |
0 |
1076333 |
1076333 |
5 % |
12/01/2016 |
Oleg Nodelman |
United States |
0 |
2449300 |
0 |
2449300 |
2449300 |
11.5 % |
18/11/2015 |
EcoR1 Capital, LLC |
Delaware |
0 |
2449300 |
0 |
2449300 |
2449300 |
11.5 % |
18/11/2015 |
EcoR1 Capital Fund, L.P. |
Delaware |
0 |
824200 |
0 |
824200 |
824200 |
3.9 % |
18/11/2015 |
EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
1625100 |
0 |
1625100 |
1625100 |
7.6 % |
18/11/2015 |
EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
1625100 |
0 |
1625100 |
1625100 |
7.6 % |
18/11/2015 |
EcoR1 Capital, LLC |
Delaware |
0 |
2449300 |
0 |
2449300 |
2449300 |
11.5 % |
18/11/2015 |
Oleg Nodelman |
United States |
0 |
2449300 |
0 |
2449300 |
2449300 |
11.5 % |
18/11/2015 |
EcoR1 Capital Fund, L.P. |
Delaware |
0 |
824200 |
0 |
824200 |
824200 |
3.9 % |
18/11/2015 |
Christopher M. James |
U.S. Citizen |
0 |
1522213 |
0 |
1522213 |
1522213 |
7.2 % |
16/11/2015 |
Partner Fund Management GP, LLC |
Delaware |
0 |
1484465 |
0 |
1484465 |
1484465 |
6.9 % |
16/11/2015 |
Partner Investment Management, L.P. |
Delaware |
0 |
48748 |
0 |
48748 |
48748 |
0.2 % |
16/11/2015 |
Partner Fund Management, L.P. |
Delaware |
0 |
1484465 |
0 |
1484465 |
1484465 |
6.9 % |
16/11/2015 |
Partner Investment Management GP, LLC |
Delaware |
0 |
48748 |
0 |
48748 |
48748 |
0.2 % |
16/11/2015 |
Partner Fund Management, L.P. |
Delaware |
0 |
1484465 |
0 |
1484465 |
1484465 |
6.9 % |
16/11/2015 |
Partner Fund Management GP, LLC |
Delaware |
0 |
1484465 |
0 |
1484465 |
1484465 |
6.9 % |
16/11/2015 |
Partner Investment Management, L.P. |
Delaware |
0 |
48748 |
0 |
48748 |
48748 |
0.2 % |
16/11/2015 |
Partner Investment Management GP, LLC |
Delaware |
0 |
48748 |
0 |
48748 |
48748 |
0.2 % |
16/11/2015 |
Brian D. Grossman |
U.S. Citizen |
0 |
1522213 |
0 |
1522213 |
1522213 |
7.2 % |
16/11/2015 |
Christopher M. James |
U.S. Citizen |
0 |
1522213 |
0 |
1522213 |
1522213 |
7.2 % |
16/11/2015 |
Brian D. Grossman |
U.S. Citizen |
0 |
1522213 |
0 |
1522213 |
1522213 |
7.2 % |
16/11/2015 |
Select Biotechnology Portfolio |
Massachusetts |
1520587 |
0 |
0 |
0 |
1520587 |
10.48 % |
10/04/2015 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
1846519 |
0 |
1846519 |
12.727 % |
10/04/2015 |
FMR LLC |
Delaware |
0 |
0 |
1846519 |
0 |
1846519 |
12.727 % |
10/04/2015 |
FMR LLC |
Delaware |
0 |
0 |
1846519 |
0 |
1846519 |
12.727 % |
10/04/2015 |
Select Biotechnology Portfolio |
Massachusetts |
1520587 |
0 |
0 |
0 |
1520587 |
10.48 % |
10/04/2015 |
Abigail P. Johnson |
United States of America |
0 |
0 |
1846519 |
0 |
1846519 |
12.727 % |
10/04/2015 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
1846519 |
0 |
1846519 |
12.727 % |
10/04/2015 |
Abigail P. Johnson |
United States of America |
0 |
0 |
1846519 |
0 |
1846519 |
12.727 % |
10/04/2015 |
EcoR1 Capital, LLC |
Delaware |
0 |
1450000 |
0 |
1450000 |
1450000 |
9.99 % |
17/03/2015 |
EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
918000 |
0 |
918000 |
918000 |
6.33 % |
17/03/2015 |
EcoR1 Capital Fund, L.P. |
Delaware |
0 |
532000 |
0 |
532000 |
532000 |
3.66 % |
17/03/2015 |
Oleg Nodelman |
United States |
0 |
1450000 |
0 |
1450000 |
1450000 |
9.99 % |
17/03/2015 |
EcoR1 Capital, LLC |
Delaware |
0 |
1450000 |
0 |
1450000 |
1450000 |
9.99 % |
17/03/2015 |
Oleg Nodelman |
United States |
0 |
1450000 |
0 |
1450000 |
1450000 |
9.99 % |
17/03/2015 |
EcoR1 Capital Fund, L.P. |
Delaware |
0 |
532000 |
0 |
532000 |
532000 |
3.66 % |
17/03/2015 |
EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
918000 |
0 |
918000 |
918000 |
6.33 % |
17/03/2015 |
Oleg Nodelman |
United States |
0 |
1450000 |
0 |
1450000 |
1450000 |
9.99 % |
17/03/2015 |
EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
918000 |
0 |
918000 |
918000 |
6.33 % |
17/03/2015 |
EcoR1 Capital, LLC |
Delaware |
0 |
1450000 |
0 |
1450000 |
1450000 |
9.99 % |
17/03/2015 |
EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
918000 |
0 |
918000 |
918000 |
6.33 % |
17/03/2015 |
EcoR1 Capital Fund, L.P. |
Delaware |
0 |
532000 |
0 |
532000 |
532000 |
3.66 % |
17/03/2015 |
Oleg Nodelman |
United States |
0 |
1450000 |
0 |
1450000 |
1450000 |
9.99 % |
17/03/2015 |
EcoR1 Capital, LLC |
Delaware |
0 |
1450000 |
0 |
1450000 |
1450000 |
9.99 % |
17/03/2015 |
EcoR1 Capital Fund, L.P. |
Delaware |
0 |
532000 |
0 |
532000 |
532000 |
3.66 % |
17/03/2015 |
Robert Nelsen |
United States of America |
0 |
1344937 |
0 |
1344937 |
1344937 |
9.3 % |
13/03/2015 |
Clinton Bybee |
United States of America |
0 |
1344937 |
0 |
1344937 |
1344937 |
9.3 % |
13/03/2015 |
Keith Crandell |
United States of America |
0 |
1344937 |
0 |
1344937 |
1344937 |
9.3 % |
13/03/2015 |
ARCH Venture Partners VIII, LLC |
Delaware |
0 |
1344937 |
0 |
1344937 |
1344937 |
9.3 % |
13/03/2015 |
ARCH Venture Fund VIII, L.P. |
Delaware |
0 |
1344937 |
0 |
1344937 |
1344937 |
9.3 % |
13/03/2015 |
ARCH Venture Partners VIII, L.P. |
Delaware |
0 |
1344937 |
0 |
1344937 |
1344937 |
9.3 % |
13/03/2015 |