The Vanguard Group |
Pennsylvania For |
0 |
12688 |
3768535 |
41435 |
3809970 |
4.32 % |
10/02/2022 |
RENAISSANCE TECHNOLOGIES HOLDINGS CORPORATION |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
10/02/2021 |
RENAISSANCE TECHNOLOGIES HOLDINGS CORPORATION |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
10/02/2021 |
Renaissance Technologies LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
10/02/2021 |
Renaissance Technologies LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
10/02/2021 |
The Vanguard Group |
Pennsylvania |
0 |
20460 |
3541797 |
49207 |
3591004 |
5.47 % |
10/02/2021 |
Sabby Management, LLC |
Delaware USA |
0 |
0 |
0 |
0 |
0 |
0 % |
05/01/2021 |
Sabby Management, LLC |
Delaware USA |
0 |
0 |
0 |
0 |
0 |
0 % |
05/01/2021 |
Sabby Volatility Warrant Master Fund, Ltd. |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
05/01/2021 |
Hal Mintz |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
05/01/2021 |
Hal Mintz |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
05/01/2021 |
Sabby Volatility Warrant Master Fund, Ltd. |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
05/01/2021 |
Sabby Volatility Warrant Master Fund, Ltd. |
Cayman Islands |
0 |
3361344 |
0 |
3361344 |
3361344 |
7.04 % |
25/02/2020 |
Hal Mintz |
USA |
0 |
3361344 |
0 |
3361344 |
3361344 |
7.04 % |
25/02/2020 |
Sabby Volatility Warrant Master Fund, Ltd. |
Cayman Islands |
0 |
3361344 |
0 |
3361344 |
3361344 |
7.04 % |
25/02/2020 |
Sabby Management, LLC |
Delaware USA |
0 |
3361344 |
0 |
3361344 |
3361344 |
7.04 % |
25/02/2020 |
Hal Mintz |
USA |
0 |
3361344 |
0 |
3361344 |
3361344 |
7.04 % |
25/02/2020 |
Sabby Management, LLC |
Delaware USA |
0 |
3361344 |
0 |
3361344 |
3361344 |
7.04 % |
25/02/2020 |
RENAISSANCE TECHNOLOGIES HOLDINGS CORPORATION |
Delaware |
1384923 |
0 |
1842303 |
58953 |
1901256 |
5.36 % |
12/02/2020 |
Renaissance Technologies LLC |
Delaware |
1384923 |
0 |
1842303 |
58953 |
1901256 |
5.36 % |
12/02/2020 |
RENAISSANCE TECHNOLOGIES HOLDINGS CORPORATION |
Delaware |
1384923 |
0 |
1842303 |
58953 |
1901256 |
5.36 % |
12/02/2020 |
Renaissance Technologies LLC |
Delaware |
1384923 |
0 |
1842303 |
58953 |
1901256 |
5.36 % |
12/02/2020 |
Sander Gerber |
United States |
0 |
3932593 |
0 |
3932593 |
3932593 |
9.99 % |
06/02/2020 |
Hudson Bay Capital Management LP |
State of Delaware |
0 |
3932593 |
0 |
3932593 |
3932593 |
9.99 % |
06/02/2020 |
Hudson Bay Capital Management LP |
State of Delaware |
0 |
3932593 |
0 |
3932593 |
3932593 |
9.99 % |
06/02/2020 |
Sander Gerber |
United States |
0 |
3932593 |
0 |
3932593 |
3932593 |
9.99 % |
06/02/2020 |
Sabby Management, LLC |
Delaware USA |
0 |
1770341 |
0 |
1770341 |
1770341 |
4.99 % |
14/01/2020 |
Sabby Volatility Warrant Master Fund, Ltd. |
Cayman Islands |
0 |
1770341 |
0 |
1770341 |
1770341 |
4.99 % |
14/01/2020 |
Hal Mintz |
USA |
0 |
1770341 |
0 |
1770341 |
1770341 |
4.99 % |
14/01/2020 |
Hal Mintz |
USA |
0 |
1770341 |
0 |
1770341 |
1770341 |
4.99 % |
14/01/2020 |
Sabby Management, LLC |
Delaware USA |
0 |
1770341 |
0 |
1770341 |
1770341 |
4.99 % |
14/01/2020 |
Sabby Volatility Warrant Master Fund, Ltd. |
Cayman Islands |
0 |
1770341 |
0 |
1770341 |
1770341 |
4.99 % |
14/01/2020 |
Hal Mintz |
USA |
0 |
3100000 |
0 |
3100000 |
3100000 |
8.74 % |
22/11/2019 |
Sabby Management, LLC |
Delaware USA |
0 |
3100000 |
0 |
3100000 |
3100000 |
8.74 % |
22/11/2019 |
Hal Mintz |
USA |
0 |
3100000 |
0 |
3100000 |
3100000 |
8.74 % |
22/11/2019 |
Sabby Volatility Warrant Master Fund, Ltd. |
Cayman Islands |
0 |
3100000 |
0 |
3100000 |
3100000 |
8.74 % |
22/11/2019 |
Sabby Management, LLC |
Delaware USA |
0 |
3100000 |
0 |
3100000 |
3100000 |
8.74 % |
22/11/2019 |
Sabby Volatility Warrant Master Fund, Ltd. |
Cayman Islands |
0 |
3100000 |
0 |
3100000 |
3100000 |
8.74 % |
22/11/2019 |
VHCP Holdings, LLC |
|
|
|
|
|
1169921 |
5.5 % |
13/02/2018 |
VHCP Management, LLC |
|
|
|
|
|
1169921 |
5.5 % |
13/02/2018 |
Koh, Bong |
|
|
|
|
|
1169921 |
5.5 % |
13/02/2018 |
Shah, Nimish |
|
|
|
|
|
1169921 |
5.5 % |
13/02/2018 |
VHCP Management II, LLC |
|
|
|
|
|
1169921 |
5.5 % |
13/02/2018 |
Venrock Healthcare Capital Partners II, L.P. |
|
|
|
|
|
1169921 |
5.5 % |
13/02/2018 |
Venrock Healthcare Capital Partners, L.P. |
|
|
|
|
|
1169921 |
5.5 % |
13/02/2018 |
VHCP Holdings II, LLC |
|
|
|
|
|
1169921 |
5.5 % |
13/02/2018 |
Invesco Ltd. |
Bermuda |
0 |
0 |
0 |
0 |
0 |
0 % |
06/02/2018 |
Royce & Associates, LP |
New York |
|
|
142204 |
|
142204 |
0.67 % |
03/01/2018 |
JG Asset, LLC |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
Visium Asset Management, LP |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
Jacob Gottlieb |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
Invesco Ltd. |
Bermuda |
1076424 |
0 |
1076424 |
0 |
1076424 |
5.9 % |
08/02/2017 |
BlackRock, Inc. |
Delaware |
952390 |
0 |
977281 |
0 |
977281 |
5.4 % |
30/01/2017 |
Royce & Associates, LP |
New York |
|
|
1178704 |
|
1178704 |
6.45 % |
11/01/2017 |
Hove, Anders 2. Check the Appropriate Box if a Member of a Group |
United States |
0 |
12699212 |
0 |
12699212 |
12699212 |
7 % |
16/02/2016 |
VHCP Holdings, LLC 2. Check the Appropriate Box if a Member of a Group |
Delaware |
0 |
12699212 |
0 |
12699212 |
12699212 |
7 % |
16/02/2016 |
VHCP Management, LLC 2. Check the Appropriate Box if a Member of a Group |
Delaware |
0 |
12699212 |
0 |
12699212 |
12699212 |
7 % |
16/02/2016 |
VHCP Management II, LLC 2. Check the appropriate box if a member of a group |
Delaware |
0 |
12699212 |
0 |
12699212 |
12699212 |
7 % |
16/02/2016 |
Koh, Bong 2. Check the Appropriate Box if a Member of a Group |
United States |
0 |
12699212 |
0 |
12699212 |
12699212 |
7 % |
16/02/2016 |
VHCP Holdings II, LLC 2. Check the appropriate box if a member of a group |
Delaware |
0 |
12699212 |
0 |
12699212 |
12699212 |
7 % |
16/02/2016 |
Venrock Healthcare Capital Partners II, L.P. 2. Check the appropriate box if a member of a group |
Delaware |
0 |
12699212 |
0 |
12699212 |
12699212 |
7 % |
16/02/2016 |
Venrock Healthcare Capital Partners, L.P. |
Delaware |
0 |
12699212 |
0 |
12699212 |
12699212 |
7 % |
16/02/2016 |
Sabby Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
187221 |
0 |
187221 |
187221 |
1.03 % |
12/01/2016 |
Sabby Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
187221 |
0 |
187221 |
187221 |
1.03 % |
12/01/2016 |
Sabby Management, LLC |
Delaware, USA |
0 |
187221 |
0 |
187221 |
187221 |
1.03 % |
12/01/2016 |
Hal Mintz |
USA |
0 |
187221 |
0 |
187221 |
187221 |
1.03 % |
12/01/2016 |
Hal Mintz |
USA |
0 |
187221 |
0 |
187221 |
187221 |
1.03 % |
12/01/2016 |
Sabby Management, LLC |
Delaware, USA |
0 |
187221 |
0 |
187221 |
187221 |
1.03 % |
12/01/2016 |
Sabby Management, LLC |
Delaware, USA |
0 |
1000000 |
0 |
1000000 |
1000000 |
5.71 % |
29/04/2015 |
Sabby Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
1000000 |
0 |
1000000 |
1000000 |
5.71 % |
29/04/2015 |
Sabby Management, LLC |
Delaware, USA |
0 |
1000000 |
0 |
1000000 |
1000000 |
5.71 % |
29/04/2015 |
Hal Mintz |
USA |
0 |
1000000 |
0 |
1000000 |
1000000 |
5.71 % |
29/04/2015 |
Sabby Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
1000000 |
0 |
1000000 |
1000000 |
5.71 % |
29/04/2015 |
Hal Mintz |
USA |
0 |
1000000 |
0 |
1000000 |
1000000 |
5.71 % |
29/04/2015 |
Janus Global Life Sciences Fund |
Massachusetts |
0 |
0 |
0 |
0 |
0 |
0 % |
02/02/2015 |
Janus Capital Management LLC EIN #753019302 |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
02/02/2015 |
Jacob Gottlieb |
United States |
0 |
1206000 |
0 |
1206000 |
1206000 |
10.9 % |
22/11/2013 |
Visium Asset Management, LP |
United States |
0 |
1206000 |
0 |
1206000 |
1206000 |
10.9 % |
22/11/2013 |
JG Asset, LLC |
United States |
0 |
1206000 |
0 |
1206000 |
1206000 |
10.9 % |
22/11/2013 |
Jacob Gottlieb |
United States |
0 |
1206000 |
0 |
1206000 |
1206000 |
10.9 % |
22/11/2013 |
JG Asset, LLC |
United States |
0 |
1206000 |
0 |
1206000 |
1206000 |
10.9 % |
22/11/2013 |
Visium Asset Management, LP |
United States |
0 |
1206000 |
0 |
1206000 |
1206000 |
10.9 % |
22/11/2013 |
Visium Balanced Master Fund, Ltd. |
Cayman Islands |
0 |
1206000 |
0 |
1206000 |
1206000 |
10.9 % |
22/11/2013 |
Visium Balanced Master Fund, Ltd. |
Cayman Islands |
0 |
1206000 |
0 |
1206000 |
1206000 |
10.9 % |
22/11/2013 |
UCB Manufacturing Ireland Ltd. |
Ireland |
580402 |
0 |
580402 |
0 |
580402 |
12.3 % |
15/08/2013 |
Visium Asset Management, LP |
United States |
0 |
1206000 |
0 |
1206000 |
1206000 |
9.9 % |
05/08/2013 |
JG Asset, LLC |
United States |
0 |
1206000 |
0 |
1206000 |
1206000 |
9.9 % |
05/08/2013 |
Jacob Gottlieb |
United States |
0 |
1206000 |
0 |
1206000 |
1206000 |
9.9 % |
05/08/2013 |
Visium Balanced Master Fund, Ltd. |
Cayman Islands |
0 |
1206000 |
0 |
1206000 |
1206000 |
9.9 % |
05/08/2013 |
Visium Balanced Master Fund, Ltd. |
Cayman Islands |
0 |
1206000 |
0 |
1206000 |
1206000 |
9.9 % |
05/08/2013 |
JG Asset, LLC |
United States |
0 |
1206000 |
0 |
1206000 |
1206000 |
9.9 % |
05/08/2013 |
Visium Asset Management, LP |
United States |
0 |
1206000 |
0 |
1206000 |
1206000 |
9.9 % |
05/08/2013 |
Jacob Gottlieb |
United States |
0 |
1206000 |
0 |
1206000 |
1206000 |
9.9 % |
05/08/2013 |
Elan Pharma International Limited |
Ireland |
0 |
81911 |
0 |
81911 |
81911 |
1.7 % |
02/08/2013 |
Elan International Services Limited |
Ireland |
0 |
718483 |
0 |
718483 |
718483 |
15.3 % |
02/08/2013 |
Elan Corporation, plc |
Ireland |
0 |
800394 |
0 |
800394 |
800394 |
17 % |
02/08/2013 |