BVF I GP LLC |
Delaware |
0 |
1579980 |
0 |
1579980 |
1579980 |
3.3 % |
14/11/2024 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
1287256 |
0 |
1287256 |
1287256 |
2.7 % |
14/11/2024 |
BVF II GP LLC |
Delaware |
0 |
1287256 |
0 |
1287256 |
1287256 |
2.7 % |
14/11/2024 |
Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
150248 |
0 |
150248 |
150248 |
0 % |
14/11/2024 |
BVF Partners OS Ltd. |
Cayman Islands |
0 |
150248 |
0 |
150248 |
150248 |
0 % |
14/11/2024 |
BVF GP Holdings LLC |
Delaware |
0 |
2867236 |
0 |
2867236 |
2867236 |
6 % |
14/11/2024 |
BVF Partners L.P. |
Delaware |
0 |
3075907 |
0 |
3075907 |
3075907 |
6.4 % |
14/11/2024 |
BVF Inc. |
Delaware |
0 |
3075907 |
0 |
3075907 |
3075907 |
6.4 % |
14/11/2024 |
Mark N. Lampert |
United States |
0 |
3075907 |
0 |
3075907 |
3075907 |
6.4 % |
14/11/2024 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
1579980 |
0 |
1579980 |
1579980 |
3.3 % |
14/11/2024 |
BlackRock, Inc. |
Delaware |
3406072 |
0 |
3368157 |
0 |
3368157 |
7.1 % |
12/11/2024 |
BlackRock, Inc. |
Delaware |
0 |
0 |
3368157 |
0 |
3368157 |
7.1 % |
22/10/2024 |
Janus Henderson Group plc EIN |
Jersey, Channel Islands |
0 |
4988747 |
0 |
4988747 |
4988747 |
10.6 % |
10/07/2024 |
Eventide Asset Management, LLC |
Delaware |
2693581 |
0 |
2693581 |
0 |
2693581 |
5.78 % |
14/02/2024 |
Robin C. John |
United States |
0 |
2693581 |
0 |
2693581 |
2693581 |
5.78 % |
14/02/2024 |
Finny Kuruvilla, M.D. Ph. D. |
United States |
0 |
2693581 |
0 |
2693581 |
2693581 |
5.78 % |
14/02/2024 |
The Vanguard Group |
Pennsylvania |
0 |
46538 |
2397149 |
79095 |
2476244 |
5.31 % |
13/02/2024 |
BVF I GP LLC |
Delaware |
0 |
2329616 |
0 |
2329616 |
2329616 |
5 % |
18/09/2023 |
Mark N. Lampert |
United States |
0 |
4370024 |
0 |
4370024 |
4370024 |
9.4 % |
18/09/2023 |
BVF Inc. |
Delaware |
0 |
4370024 |
0 |
4370024 |
4370024 |
9.4 % |
18/09/2023 |
BVF Partners L.P. |
Delaware |
0 |
4370024 |
0 |
4370024 |
4370024 |
9.4 % |
18/09/2023 |
BVF GP Holdings LLC |
Delaware |
0 |
4101829 |
0 |
4101829 |
4101829 |
8.9 % |
18/09/2023 |
BVF Partners OS Ltd. |
Cayman Islands |
0 |
207079 |
0 |
207079 |
207079 |
0 % |
18/09/2023 |
Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
207079 |
0 |
207079 |
207079 |
0 % |
18/09/2023 |
BVF II GP LLC |
Delaware |
0 |
1772213 |
0 |
1772213 |
1772213 |
3.8 % |
18/09/2023 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
1772213 |
0 |
1772213 |
1772213 |
3.8 % |
18/09/2023 |
BVF I GP LLC |
Delaware |
0 |
2329616 |
0 |
2329616 |
2329616 |
5 % |
18/09/2023 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
2329616 |
0 |
2329616 |
2329616 |
5 % |
18/09/2023 |
Mark N. Lampert |
United States |
0 |
4370024 |
0 |
4370024 |
4370024 |
9.4 % |
18/09/2023 |
BVF Inc. |
Delaware |
0 |
4370024 |
0 |
4370024 |
4370024 |
9.4 % |
18/09/2023 |
BVF Partners L.P. |
Delaware |
0 |
4370024 |
0 |
4370024 |
4370024 |
9.4 % |
18/09/2023 |
BVF GP Holdings LLC |
Delaware |
0 |
4101829 |
0 |
4101829 |
4101829 |
8.9 % |
18/09/2023 |
BVF Partners OS Ltd. |
Cayman Islands |
0 |
207079 |
0 |
207079 |
207079 |
0 % |
18/09/2023 |
Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
207079 |
0 |
207079 |
207079 |
0 % |
18/09/2023 |
BVF II GP LLC |
Delaware |
0 |
1772213 |
0 |
1772213 |
1772213 |
3.8 % |
18/09/2023 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
1772213 |
0 |
1772213 |
1772213 |
3.8 % |
18/09/2023 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
2329616 |
0 |
2329616 |
2329616 |
5 % |
18/09/2023 |
S Deerfield Private Design Fund IV, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
03/05/2023 |
S Deerfield Healthcare Innovations Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
03/05/2023 |
S Deerfield Mgmt HIF, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
03/05/2023 |
S Deerfield Management Company, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
03/05/2023 |
S Deerfield Mgmt IV, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
03/05/2023 |
S James E. Flynn |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
03/05/2023 |
S Deerfield Private Design Fund IV, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
03/05/2023 |
S Deerfield Mgmt IV, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
03/05/2023 |
S Deerfield Healthcare Innovations Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
03/05/2023 |
S Deerfield Mgmt HIF, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
03/05/2023 |
S Deerfield Management Company, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
03/05/2023 |
S James E. Flynn |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
03/05/2023 |
BlackRock, Inc. |
Delaware |
1637679 |
0 |
1677907 |
0 |
1677907 |
4.6 % |
08/03/2023 |
Deerfield Mgmt HIF, L.P. |
Delaware |
0 |
964784 |
0 |
964784 |
964784 |
2.62 % |
10/02/2023 |
Deerfield Management Company, L.P. |
Delaware |
0 |
2032335 |
0 |
2032335 |
2032335 |
5.51 % |
10/02/2023 |
Deerfield Healthcare Innovations Fund, L.P. |
Delaware |
0 |
964784 |
0 |
964784 |
964784 |
2.62 % |
10/02/2023 |
Deerfield Mgmt IV, L.P. |
Delaware |
0 |
1067551 |
0 |
1067551 |
1067551 |
2.9 % |
10/02/2023 |
Deerfield Private Design Fund IV, L.P. |
Delaware |
0 |
1067551 |
0 |
1067551 |
1067551 |
2.9 % |
10/02/2023 |
James E. Flynn |
United States |
0 |
2032335 |
0 |
2032335 |
2032335 |
5.51 % |
10/02/2023 |
Deerfield Management Company, L.P. |
Delaware |
0 |
2032335 |
0 |
2032335 |
2032335 |
5.51 % |
10/02/2023 |
Deerfield Mgmt HIF, L.P. |
Delaware |
0 |
964784 |
0 |
964784 |
964784 |
2.62 % |
10/02/2023 |
Deerfield Healthcare Innovations Fund, L.P. |
Delaware |
0 |
964784 |
0 |
964784 |
964784 |
2.62 % |
10/02/2023 |
Deerfield Mgmt IV, L.P. |
Delaware |
0 |
1067551 |
0 |
1067551 |
1067551 |
2.9 % |
10/02/2023 |
Deerfield Private Design Fund IV, L.P. |
Delaware |
0 |
1067551 |
0 |
1067551 |
1067551 |
2.9 % |
10/02/2023 |
James E. Flynn |
United States |
0 |
2032335 |
0 |
2032335 |
2032335 |
5.51 % |
10/02/2023 |
Deerfield Mgmt IV, L.P. |
Delaware |
0 |
1067551 |
0 |
1067551 |
1067551 |
2.91 % |
12/09/2022 |
Deerfield Management Company, L.P. |
Delaware |
0 |
2032335 |
0 |
2032335 |
2032335 |
5.53 % |
12/09/2022 |
Deerfield Mgmt HIF, L.P. |
Delaware |
0 |
964784 |
0 |
964784 |
964784 |
2.63 % |
12/09/2022 |
Deerfield Healthcare Innovations Fund, L.P. |
Delaware |
0 |
964784 |
0 |
964784 |
964784 |
2.63 % |
12/09/2022 |
Deerfield Mgmt IV, L.P. |
Delaware |
0 |
1067551 |
0 |
1067551 |
1067551 |
2.91 % |
12/09/2022 |
Deerfield Private Design Fund IV, L.P. |
Delaware |
0 |
1067551 |
0 |
1067551 |
1067551 |
2.91 % |
12/09/2022 |
James E. Flynn |
United States |
0 |
2032335 |
0 |
2032335 |
2032335 |
5.53 % |
12/09/2022 |
Deerfield Management Company, L.P. |
Delaware |
0 |
2032335 |
0 |
2032335 |
2032335 |
5.53 % |
12/09/2022 |
Deerfield Mgmt HIF, L.P. |
Delaware |
0 |
964784 |
0 |
964784 |
964784 |
2.63 % |
12/09/2022 |
Deerfield Healthcare Innovations Fund, L.P. |
Delaware |
0 |
964784 |
0 |
964784 |
964784 |
2.63 % |
12/09/2022 |
James E. Flynn |
United States |
0 |
2032335 |
0 |
2032335 |
2032335 |
5.53 % |
12/09/2022 |
Deerfield Private Design Fund IV, L.P. |
Delaware |
0 |
1067551 |
0 |
1067551 |
1067551 |
2.91 % |
12/09/2022 |
Rock Springs Capital Management LP |
Delaware |
0 |
1496525 |
0 |
1496525 |
0 |
5.08 % |
16/02/2021 |
Rock Springs Capital Master Fund LP |
Cayman Islands |
0 |
1450000 |
0 |
1450000 |
0 |
4.92 % |
16/02/2021 |
Rock Springs Capital Master Fund LP |
Cayman Islands |
0 |
1450000 |
0 |
1450000 |
0 |
4.92 % |
16/02/2021 |
Rock Springs Capital Management LP |
Delaware |
0 |
1496525 |
0 |
1496525 |
0 |
5.08 % |
16/02/2021 |
Rock Springs Capital LLC |
Delaware |
0 |
1496525 |
0 |
1496525 |
0 |
5.08 % |
16/02/2021 |
Rock Springs Capital LLC |
Delaware |
0 |
1496525 |
0 |
1496525 |
0 |
5.08 % |
16/02/2021 |
Rock Springs Capital Management LP |
Delaware |
0 |
1245000 |
0 |
1245000 |
0 |
5.42 % |
14/02/2020 |
Rock Springs Capital Master Fund LP |
Cayman Islands |
0 |
1245000 |
0 |
1245000 |
0 |
5.42 % |
14/02/2020 |
Rock Springs Capital LLC |
Delaware |
0 |
1245000 |
0 |
1245000 |
0 |
5.42 % |
14/02/2020 |
S Deerfield Private Design Fund IV, L.P. |
Delaware |
0 |
1724456 |
0 |
1724456 |
1724456 |
7.5 % |
13/02/2020 |
S Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
166000 |
0 |
166000 |
166000 |
0.72 % |
13/02/2020 |
S Deerfield Healthcare Innovations Fund, L.P. |
Delaware |
0 |
1558456 |
0 |
1558456 |
1558456 |
6.78 % |
13/02/2020 |
S Deerfield Mgmt HIF, L.P. |
Delaware |
0 |
1558456 |
0 |
1558456 |
1558456 |
6.78 % |
13/02/2020 |
S Deerfield Management Company, L.P. |
Delaware |
0 |
3448912 |
0 |
3448912 |
3448912 |
15 % |
13/02/2020 |
S Deerfield Mgmt, L.P. |
Delaware |
0 |
166000 |
0 |
166000 |
166000 |
0.72 % |
13/02/2020 |
S James E. Flynn |
United States |
0 |
3448912 |
0 |
3448912 |
3448912 |
15 % |
13/02/2020 |
S Deerfield Mgmt IV, L.P. |
Delaware |
0 |
1724456 |
0 |
1724456 |
1724456 |
7.5 % |
13/02/2020 |
Rock Springs Capital Management LP |
Delaware |
0 |
1400000 |
0 |
1400000 |
0 |
6.09 % |
16/12/2019 |
Rock Springs Capital Master Fund LP |
Cayman Islands |
0 |
1400000 |
0 |
1400000 |
0 |
6.09 % |
16/12/2019 |
Rock Springs Capital LLC |
Delaware |
0 |
1400000 |
0 |
1400000 |
0 |
6.09 % |
16/12/2019 |
Rock Springs Capital Management LP |
Delaware |
0 |
1400000 |
0 |
1400000 |
0 |
6.09 % |
16/12/2019 |
Rock Springs Capital Master Fund LP |
Cayman Islands |
0 |
1400000 |
0 |
1400000 |
0 |
6.09 % |
16/12/2019 |
Rock Springs Capital LLC |
Delaware |
0 |
1400000 |
0 |
1400000 |
0 |
6.09 % |
16/12/2019 |
Shire International GmbH |
Switzerland |
0 |
1859151 |
0 |
1859151 |
1859151 |
8.1 % |
10/09/2019 |
Takeda Pharmaceutical Company Limited |
Japan |
0 |
1859151 |
0 |
1859151 |
1859151 |
8.1 % |
10/09/2019 |
James E. Flynn |
United States |
0 |
3448912 |
0 |
3448912 |
3448912 |
14.98 % |
24/07/2019 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
166000 |
0 |
166000 |
166000 |
0.72 % |
24/07/2019 |
Deerfield Management Company, L.P. |
Delaware |
0 |
3448912 |
0 |
3448912 |
3448912 |
14.98 % |
24/07/2019 |
Deerfield Mgmt HIF, L.P. |
Delaware |
0 |
1558456 |
0 |
1558456 |
1558456 |
6.77 % |
24/07/2019 |
Deerfield Healthcare Innovations Fund, L.P. |
Delaware |
0 |
1558456 |
0 |
1558456 |
1558456 |
6.77 % |
24/07/2019 |
Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
166000 |
0 |
166000 |
166000 |
0.72 % |
24/07/2019 |
Deerfield Mgmt IV, L.P. |
Delaware |
0 |
1724456 |
0 |
1724456 |
1724456 |
7.49 % |
24/07/2019 |
Deerfield Private Design Fund IV, L.P. |
Delaware |
0 |
1724456 |
0 |
1724456 |
1724456 |
7.49 % |
24/07/2019 |
James E. Flynn |
United States |
0 |
3448912 |
0 |
3448912 |
3448912 |
14.98 % |
24/07/2019 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
166000 |
0 |
166000 |
166000 |
0.72 % |
24/07/2019 |
Deerfield Management Company, L.P. |
Delaware |
0 |
3448912 |
0 |
3448912 |
3448912 |
14.98 % |
24/07/2019 |
Deerfield Mgmt HIF, L.P. |
Delaware |
0 |
1558456 |
0 |
1558456 |
1558456 |
6.77 % |
24/07/2019 |
Deerfield Healthcare Innovations Fund, L.P. |
Delaware |
0 |
1558456 |
0 |
1558456 |
1558456 |
6.77 % |
24/07/2019 |
Deerfield Mgmt IV, L.P. |
Delaware |
0 |
1724456 |
0 |
1724456 |
1724456 |
7.49 % |
24/07/2019 |
Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
166000 |
0 |
166000 |
166000 |
0.72 % |
24/07/2019 |
Deerfield Private Design Fund IV, L.P. |
Delaware |
0 |
1724456 |
0 |
1724456 |
1724456 |
7.49 % |
24/07/2019 |