| (1) BlackRock, Inc. |
Delaware |
0 |
0 |
3368157 |
0 |
3368157 |
7.1 % |
22/10/2024 |
| EIN #00-0000000 |
Jersey, Channel Islands |
0 |
4988747 |
0 |
4988747 |
4988747 |
10.6 % |
10/07/2024 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
0 |
46538 |
0 |
0 |
2476244 |
5.31 % |
13/02/2024 |
| (1) BlackRock, Inc. |
Delaware |
2494254 |
0 |
2532642 |
0 |
2532642 |
5.4 % |
31/01/2024 |
| BVF I GP LLC |
Delaware |
0 |
0 |
0 |
2329616 |
2329616 |
5 % |
18/09/2023 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
1772213 |
1772213 |
3.8 % |
18/09/2023 |
| BVF II GP LLC |
Delaware |
0 |
0 |
0 |
1772213 |
1772213 |
3.8 % |
18/09/2023 |
| BVF GP Holdings LLC |
Delaware |
0 |
0 |
0 |
4101829 |
4101829 |
8.9 % |
18/09/2023 |
| BVF Inc. |
Delaware |
0 |
0 |
0 |
4370024 |
4370024 |
9.4 % |
18/09/2023 |
| Mark N. Lampert |
Delaware |
0 |
0 |
0 |
4370024 |
4370024 |
9.4 % |
18/09/2023 |
| Biotechnology Value Trading Fund OS LP |
Delaware |
0 |
0 |
0 |
207079 |
207079 |
1 % |
18/09/2023 |
| BVF Partners OS Ltd. |
Delaware |
0 |
0 |
0 |
207079 |
207079 |
1 % |
18/09/2023 |
| BVF Partners L.P. |
Delaware |
0 |
0 |
0 |
4370024 |
4370024 |
9.4 % |
18/09/2023 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
2329616 |
2329616 |
5 % |
18/09/2023 |
| Robin C. John |
United States |
0 |
2057000 |
0 |
0 |
2057000 |
5.6 % |
14/02/2023 |
| Eventide Asset Management, LLC |
Delaware |
2057000 |
0 |
2057000 |
0 |
2057000 |
5.6 % |
14/02/2023 |
| Finny Kuruvilla, M.D. Ph. D. |
United States |
0 |
2057000 |
0 |
0 |
2057000 |
5.6 % |
14/02/2023 |
| (1) BlackRock, Inc. |
Delaware |
1993024 |
0 |
2136677 |
0 |
2136677 |
5.8 % |
03/02/2023 |
| Deerfield Mgmt HIF, L.P. |
Delaware |
0 |
964784 |
0 |
0 |
964784 |
2.63 % |
12/09/2022 |
| Deerfield Healthcare Innovations Fund, L.P. |
Delaware |
0 |
964784 |
0 |
0 |
964784 |
2.63 % |
12/09/2022 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
2032335 |
0 |
0 |
2032335 |
5.53 % |
12/09/2022 |
| Deerfield Mgmt IV, L.P. |
Delaware |
0 |
1067551 |
0 |
0 |
1067551 |
2.91 % |
12/09/2022 |
| Deerfield Private Design Fund IV, L.P. |
Delaware |
0 |
1067551 |
0 |
0 |
1067551 |
2.91 % |
12/09/2022 |
| James E. Flynn |
Delaware |
0 |
2032335 |
0 |
0 |
2032335 |
5.53 % |
12/09/2022 |
| Rock Springs Capital LLC |
Delaware |
0 |
1538814 |
0 |
0 |
1538814 |
5.02 % |
14/02/2022 |
| Rock Springs Capital Master Fund LP |
Cayman Islands |
0 |
1450000 |
0 |
0 |
1450000 |
4.73 % |
14/02/2022 |
| Rock Springs Capital Management LP |
Delaware |
0 |
1538814 |
0 |
0 |
1538814 |
5.02 % |
14/02/2022 |
| Company, L.P. |
Delaware |
0 |
3282912 |
0 |
0 |
3282912 |
10.72 % |
11/02/2022 |
| James E. Flynn |
United States |
0 |
3282912 |
0 |
0 |
3282912 |
10.72 % |
11/02/2022 |
| Deerfield Mgmt HIF, L.P. |
Delaware |
0 |
1558456 |
0 |
0 |
1558456 |
5.09 % |
11/02/2022 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2022 |
| Deerfield Private Design Fund IV, L.P. |
Delaware |
0 |
1724456 |
0 |
0 |
1724456 |
5.63 % |
11/02/2022 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2022 |
| Deerfield Mgmt IV, L.P. |
Delaware |
0 |
1724456 |
0 |
0 |
1724456 |
5.63 % |
11/02/2022 |
| Deerfield Healthcare Innovations Fund, L.P. |
Delaware |
0 |
1558456 |
0 |
0 |
1558456 |
5.09 % |
11/02/2022 |
| Rock Springs Capital Management LP |
Delaware |
0 |
1496525 |
0 |
0 |
1496525 |
5.08 % |
16/02/2021 |
| Rock Springs Capital Master Fund LP |
Delaware |
0 |
1450000 |
0 |
0 |
1450000 |
4.92 % |
16/02/2021 |
| Rock Springs Capital LLC |
Delaware |
0 |
1496525 |
0 |
0 |
1496525 |
5.08 % |
16/02/2021 |
| Shire International GmbH in Liquidation |
|
0 |
0 |
0 |
0 |
0 |
0 % |
27/01/2021 |
| Takeda Pharmaceutical Company Limited |
|
0 |
1859151 |
0 |
0 |
1859151 |
7.2 % |
27/01/2021 |
| Takeda Pharmaceuticals U.S.A., Inc. |
|
0 |
1859151 |
0 |
0 |
1859151 |
7.2 % |
27/01/2021 |
| Deerfield Healthcare Innovations Fund, L.P. |
Delaware |
0 |
1558456 |
0 |
0 |
1558456 |
6.78 % |
13/02/2020 |
| Deerfield Mgmt IV, L.P. |
Delaware |
0 |
1724456 |
0 |
0 |
1724456 |
7.5 % |
13/02/2020 |
| Deerfield Private Design Fund IV, L.P. |
Delaware |
0 |
1724456 |
0 |
0 |
1724456 |
7.5 % |
13/02/2020 |
| James E. Flynn |
Delaware |
0 |
3448912 |
0 |
0 |
3448912 |
15 % |
13/02/2020 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
166000 |
0 |
0 |
166000 |
0.72 % |
13/02/2020 |
| Company, L.P. |
Delaware |
0 |
3448912 |
0 |
0 |
3448912 |
15 % |
13/02/2020 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
166000 |
0 |
0 |
166000 |
0.72 % |
13/02/2020 |
| Deerfield Mgmt HIF, L.P. |
Delaware |
0 |
1558456 |
0 |
0 |
1558456 |
6.78 % |
13/02/2020 |
| Rock Springs Capital Management LP |
Delaware |
0 |
1400000 |
0 |
0 |
1400000 |
6.09 % |
16/12/2019 |
| Rock Springs Capital Master Fund LP |
Delaware |
0 |
1400000 |
0 |
0 |
1400000 |
6.09 % |
16/12/2019 |
| Rock Springs Capital LLC |
Delaware |
0 |
1400000 |
0 |
0 |
1400000 |
6.09 % |
16/12/2019 |
| Shire International GmbH |
Switzerland |
0 |
1859151 |
0 |
1859151 |
1859151 |
8.1 % |
10/09/2019 |
| Takeda Pharmaceutical Company Limited |
Switzerland |
0 |
1859151 |
0 |
1859151 |
1859151 |
8.1 % |
10/09/2019 |
| FHMLS IX, L.L.C. |
Delaware |
0 |
3566912 |
0 |
3566912 |
3566912 |
15.5 % |
26/07/2019 |
| Patrick Heron |
Citizen |
0 |
3566912 |
0 |
3566912 |
3566912 |
15.5 % |
26/07/2019 |
| Frazier Life Sciences IX, L.P. |
Delaware |
0 |
3566912 |
0 |
3566912 |
3566912 |
15.5 % |
26/07/2019 |
| James Topper |
Citizen |
0 |
3566912 |
0 |
3566912 |
3566912 |
15.5 % |
26/07/2019 |
| FHMLS IX, L.P. |
Delaware |
0 |
3566912 |
0 |
3566912 |
3566912 |
15.5 % |
26/07/2019 |
| Company, L.P. |
Delaware |
0 |
3448912 |
0 |
0 |
3448912 |
14.98 % |
24/07/2019 |
| Deerfield Mgmt IV, L.P. |
Delaware |
0 |
1724456 |
0 |
0 |
1724456 |
7.49 % |
24/07/2019 |
| Deerfield Private Design Fund IV, L.P. |
Delaware |
0 |
1724456 |
0 |
0 |
1724456 |
7.49 % |
24/07/2019 |
| James E. Flynn |
Delaware |
0 |
3448912 |
0 |
0 |
3448912 |
14.98 % |
24/07/2019 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
166000 |
0 |
0 |
166000 |
0.72 % |
24/07/2019 |
| Deerfield Mgmt HIF, L.P. |
Delaware |
0 |
1558456 |
0 |
0 |
1558456 |
6.77 % |
24/07/2019 |
| Deerfield Healthcare Innovations Fund, L.P. |
Delaware |
0 |
1558456 |
0 |
0 |
1558456 |
6.77 % |
24/07/2019 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
166000 |
0 |
0 |
166000 |
0.72 % |
24/07/2019 |