| Velan Capital Master Fund LP |
CAYMAN ISLANDS |
0 |
0 |
0 |
2054000 |
2054000 |
5.9 % |
17/12/2024 |
| Velan Horizon GP LLC |
CAYMAN ISLANDS |
0 |
0 |
0 |
5000 |
5000 |
1 % |
17/12/2024 |
| Velan Capital Investment Management LP |
CAYMAN ISLANDS |
0 |
0 |
0 |
2059000 |
2059000 |
5.9 % |
17/12/2024 |
| Velan Capital Management LLC |
CAYMAN ISLANDS |
0 |
0 |
0 |
2059000 |
2059000 |
5.9 % |
17/12/2024 |
| Adam Morgan |
CAYMAN ISLANDS |
0 |
0 |
0 |
2059000 |
2059000 |
5.9 % |
17/12/2024 |
| Balaji Venkataraman |
CAYMAN ISLANDS |
0 |
0 |
0 |
2059000 |
2059000 |
5.9 % |
17/12/2024 |
| Velan Capital Holdings LLC |
CAYMAN ISLANDS |
0 |
0 |
0 |
2054000 |
2054000 |
5.9 % |
17/12/2024 |
| Velan Horizon Fund LP |
CAYMAN ISLANDS |
0 |
0 |
0 |
5000 |
5000 |
1 % |
17/12/2024 |
| 20-5648796 |
Massachusetts |
0 |
1681154 |
0 |
1681154 |
1681154 |
8.15 % |
18/11/2024 |
| Woodline Partners LP |
Delaware |
1576567 |
0 |
1576567 |
0 |
1576567 |
7.4 % |
14/11/2024 |
| s |
Delaware |
0 |
2073075 |
0 |
2073075 |
2073075 |
9.99 % |
25/04/2024 |
| s |
Delaware |
0 |
2073075 |
0 |
2073075 |
2073075 |
9.99 % |
25/04/2024 |
| s |
Delaware |
0 |
2073075 |
0 |
2073075 |
2073075 |
9.99 % |
25/04/2024 |
| s |
Delaware |
0 |
2073075 |
0 |
2073075 |
2073075 |
9.99 % |
25/04/2024 |
| 2. |
Delaware |
0 |
9189 |
0 |
0 |
10 |
0 % |
22/04/2024 |
| 2. |
Delaware |
0 |
1203943 |
0 |
0 |
10 |
5.7 % |
22/04/2024 |
| 2. |
Delaware |
0 |
1213132 |
0 |
0 |
10 |
5.7 % |
22/04/2024 |
| 2. |
Delaware |
0 |
9189 |
0 |
0 |
10 |
0 % |
22/04/2024 |
| 2. |
Delaware |
0 |
1203943 |
0 |
0 |
10 |
5.7 % |
22/04/2024 |
| 2. |
Delaware |
0 |
9189 |
0 |
0 |
10 |
0 % |
22/04/2024 |
| 2. |
Delaware |
0 |
1203943 |
0 |
0 |
10 |
5.7 % |
22/04/2024 |
| Heights Capital Management, Inc. |
Delaware |
0 |
600380 |
0 |
600380 |
600380 |
5.3 % |
09/04/2024 |
| CVI Investments, Inc. |
Cayman Islands |
0 |
600380 |
0 |
600380 |
600380 |
5.3 % |
09/04/2024 |
| Advisors LLC |
Delaware |
0 |
421641 |
0 |
421641 |
421641 |
3.8 % |
14/02/2022 |
| Sciences Master Fund, Ltd. |
Delaware |
0 |
421641 |
0 |
421641 |
421641 |
3.8 % |
14/02/2022 |
| Edelman |
Delaware |
0 |
421641 |
0 |
421641 |
421641 |
3.8 % |
14/02/2022 |
| Rock Springs Capital Management LP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| Rock Springs Capital Master Fund LP |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| Rock Springs Capital LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| OrbiMed Capital LLC |
Delaware |
671741 |
0 |
671741 |
0 |
671741 |
6 % |
11/02/2022 |
| OrbiMed Advisors LLC |
Delaware |
0 |
158900 |
0 |
0 |
158900 |
1.4 % |
11/02/2022 |
| Rock Springs Capital Management LP |
Delaware |
0 |
643622 |
0 |
0 |
643622 |
6.16 % |
02/10/2020 |
| Rock Springs Capital LLC |
Delaware |
0 |
643622 |
0 |
0 |
643622 |
6.16 % |
02/10/2020 |
| Rock Springs Capital Master Fund LP |
Delaware |
0 |
625000 |
0 |
0 |
625000 |
5.98 % |
02/10/2020 |
| 2 |
Delaware |
0 |
608544 |
0 |
608544 |
608544 |
5.8 % |
01/10/2020 |
| Ikarian Healthcare Master Fund, L.P. |
Delaware |
0 |
260171 |
0 |
0 |
260171 |
4.5 % |
21/02/2020 |
| Ikarian Healthcare Fund GP, L.P. |
Delaware |
0 |
260171 |
0 |
0 |
260171 |
4.5 % |
21/02/2020 |
| Chart Westcott |
Delaware |
0 |
307308 |
0 |
0 |
307308 |
5.3 % |
21/02/2020 |
| Neil Shahrestani |
Delaware |
0 |
307308 |
0 |
0 |
307308 |
5.3 % |
21/02/2020 |
| Ikarian Capital, LLC |
Delaware |
0 |
307308 |
0 |
0 |
307308 |
5.3 % |
21/02/2020 |
| Management Inc. |
Massachusetts |
0 |
2208472 |
0 |
2208472 |
2208472 |
37.79 % |
21/01/2020 |
| L.P. |
Delaware |
0 |
2208472 |
0 |
2208472 |
2208472 |
37.79 % |
21/01/2020 |
| Silverman |
States |
0 |
2208472 |
0 |
2208472 |
5036010 |
37.79 % |
21/01/2020 |
| Abingworth Bioventures VI, LP |
England |
0 |
113920 |
0 |
0 |
113920 |
1.9 % |
17/01/2020 |
| Abingworth LLP |
England |
0 |
113920 |
0 |
0 |
113920 |
1.9 % |
17/01/2020 |
| Donald R. Wilson, Jr. |
Delaware |
448751 |
0 |
448751 |
0 |
448751 |
7.68 % |
16/01/2020 |
| DRW Holdings, LLC |
Delaware |
448751 |
0 |
448751 |
0 |
448751 |
7.68 % |
16/01/2020 |
| DRW Management LLC |
Delaware |
448751 |
0 |
448751 |
0 |
448751 |
7.68 % |
16/01/2020 |
| DRW Venture Capital LLC |
Delaware |
448751 |
0 |
448751 |
0 |
448751 |
7.68 % |
16/01/2020 |
| Lathi |
Delaware |
0 |
1523200 |
0 |
1523200 |
1523200 |
8.6 % |
06/11/2018 |
| Manke |
Delaware |
0 |
1523200 |
0 |
1523200 |
1523200 |
8.6 % |
06/11/2018 |
| Opportunities II, L.P. (“Biopharma II”) |
Delaware |
1523200 |
0 |
1523200 |
0 |
1523200 |
8.6 % |
06/11/2018 |
| Associates II, L.P. |
Delaware |
1523200 |
0 |
1523200 |
0 |
1523200 |
8.6 % |
06/11/2018 |
| Hunt |
Delaware |
0 |
1523200 |
0 |
1523200 |
1523200 |
8.6 % |
06/11/2018 |
| Management II, L.L.C. |
Delaware |
1523200 |
0 |
1523200 |
0 |
1523200 |
8.6 % |
06/11/2018 |
| Ratcliffe |
Delaware |
0 |
1523200 |
0 |
1523200 |
1523200 |
8.6 % |
06/11/2018 |
| Peter Kolchinsky |
Massachusetts |
0 |
1679205 |
0 |
1679205 |
1679205 |
9.4 % |
14/02/2018 |
| RA Capital Management, LLC |
Massachusetts |
0 |
1679205 |
0 |
1679205 |
1679205 |
9.4 % |
14/02/2018 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
| FMR LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
| James E. Flynn |
United States |
0 |
1332599 |
0 |
0 |
1332599 |
8.03 % |
14/02/2017 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
1332599 |
0 |
0 |
1332599 |
8.03 % |
14/02/2017 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
454800 |
0 |
0 |
454800 |
2.74 % |
14/02/2017 |
| Deerfield Mgmt III, L.P. |
Delaware |
0 |
877799 |
0 |
0 |
877799 |
5.29 % |
14/02/2017 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
454800 |
0 |
0 |
454800 |
2.74 % |
14/02/2017 |
| Deerfield Private Design Fund III, L.P. |
Delaware |
0 |
877799 |
0 |
0 |
877799 |
5.29 % |
14/02/2017 |
| James E. Flynn |
United States |
0 |
1265343 |
0 |
0 |
1265343 |
7.68 % |
16/02/2016 |
| Deerfield Private Design Fund III, L.P. |
British Virgin Islands |
0 |
877799 |
0 |
0 |
877799 |
5.32 % |
16/02/2016 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
387544 |
0 |
0 |
387544 |
2.35 % |
16/02/2016 |
| Deerfield Mgmt III, L.P. |
Delaware |
0 |
877799 |
0 |
0 |
877799 |
5.32 % |
16/02/2016 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
1265343 |
0 |
0 |
1265343 |
7.68 % |
16/02/2016 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
387544 |
0 |
0 |
387544 |
2.35 % |
16/02/2016 |
| Deerfield Special Situations International Master Fund, L.P. |
British Virgin Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
| Mitch Mumma |
Citizenship or Place of Organization |
0 |
0 |
0 |
898383 |
898383 |
5.5 % |
07/04/2015 |
| Dennis Dougherty |
Citizenship or Place of Organization |
0 |
0 |
0 |
898383 |
898383 |
5.5 % |
07/04/2015 |
| Intersouth Partners VI, L.P. |
Citizenship or Place of Organization |
0 |
0 |
0 |
898383 |
898383 |
5.5 % |
07/04/2015 |
| Intersouth Associates VI, LLC |
Citizenship or Place of Organization |
0 |
0 |
0 |
898383 |
898383 |
5.5 % |
07/04/2015 |
| FMR LLC |
Delaware |
0 |
0 |
850000 |
0 |
850000 |
5.167 % |
13/02/2015 |
| Edward C. Johnson 3d |
United States of America |
0 |
0 |
850000 |
0 |
850000 |
5.167 % |
13/02/2015 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
850000 |
0 |
850000 |
5.167 % |
13/02/2015 |
| Steven J. Benson |
United States of America |
0 |
1253886 |
0 |
0 |
1253886 |
7.6 % |
12/02/2015 |
| Prism Venture Partners V, LLC |
Delaware |
0 |
1253886 |
0 |
0 |
1253886 |
7.6 % |
12/02/2015 |
| Prism Venture Partners V, L.P. |
Delaware |
0 |
1253886 |
0 |
0 |
1253886 |
7.6 % |
12/02/2015 |
| Brendan O’Leary |
United States of America |
0 |
1253886 |
0 |
0 |
1253886 |
7.6 % |
12/02/2015 |
| Prism Venture Partners V-A, L.P. |
Delaware |
0 |
1253886 |
0 |
0 |
1253886 |
7.6 % |
12/02/2015 |
| Prism Investment Partners V, L.P. |
Delaware |
0 |
1253886 |
0 |
0 |
1253886 |
7.6 % |
12/02/2015 |
| James A. Counihan |
United States of America |
0 |
1253886 |
0 |
0 |
1253886 |
7.6 % |
12/02/2015 |
| 10. |
Delaware |
0 |
983381 |
0 |
983381 |
983381 |
6 % |
05/02/2015 |
| 10. |
Delaware |
983381 |
0 |
983381 |
0 |
983381 |
6 % |
05/02/2015 |
| 10. |
Delaware |
0 |
983381 |
0 |
983381 |
983381 |
6 % |
05/02/2015 |
| 10. |
Delaware |
0 |
983381 |
0 |
983381 |
983381 |
6 % |
05/02/2015 |
| 10. |
Delaware |
0 |
983381 |
0 |
983381 |
983381 |
6 % |
05/02/2015 |
| 10. |
Delaware |
0 |
983381 |
0 |
983381 |
983381 |
6 % |
05/02/2015 |
| 10. |
Delaware |
0 |
983381 |
0 |
983381 |
983381 |
6 % |
05/02/2015 |
| 6.0% |
Delaware |
0 |
983381 |
0 |
983381 |
983381 |
6 % |
05/02/2015 |
| TVM Life Science Ventures VI L.P. |
Cayman Islands |
0 |
1943059 |
0 |
10 |
1943059 |
13 % |
04/11/2014 |
| TVM Life Science Ventures VI GmbH & Co. KG |
Germany |
0 |
1943059 |
0 |
10 |
1943059 |
13 % |
04/11/2014 |
| Alexandra Goll |
German |
0 |
1943059 |
0 |
10 |
1943059 |
13 % |
04/11/2014 |
| Helmut Schuhsler |
Austrian |
0 |
1943059 |
0 |
10 |
1943059 |
13 % |
04/11/2014 |
| Hubert Birner |
German |
0 |
1943059 |
0 |
10 |
1943059 |
13 % |
04/11/2014 |
| Stefan Fischer |
German |
0 |
1943059 |
0 |
10 |
1943059 |
13 % |
04/11/2014 |
| TVM Life Science Ventures Management VI L.P. |
Delaware |
0 |
1943059 |
0 |
10 |
1943059 |
13 % |
04/11/2014 |
| Skyline Venture Partners Qualified Purchaser Fund IV, L.P. |
Delaware, United States of America |
0 |
1432930 |
0 |
10 |
1432930 |
9.6 % |
03/11/2014 |
| Yasunori Kaneko |
United States of America |
0 |
1432930 |
0 |
10 |
1432930 |
9.6 % |
03/11/2014 |
| Skyline Venture Management IV, LLC |
California, United States of America |
0 |
1432930 |
0 |
10 |
1432930 |
9.6 % |
03/11/2014 |
| John G. Freund |
United States of America |
0 |
1432930 |
0 |
10 |
1432930 |
9.6 % |
03/11/2014 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
1025000 |
0 |
0 |
1025000 |
6.8 % |
31/10/2014 |
| Peter Kolchinsky |
Citizenship or Place of Organization |
0 |
1250000 |
0 |
0 |
1250000 |
8.3 % |
31/10/2014 |
| RA Capital Management, LLC |
Massachusetts |
0 |
1250000 |
0 |
0 |
1250000 |
8.3 % |
31/10/2014 |
| Abingworth Bioventures VI, LP |
England |
0 |
2017872 |
0 |
0 |
2017872 |
13.5 % |
31/10/2014 |
| Abingworth LLP |
England |
0 |
2017872 |
0 |
0 |
2017872 |
13.5 % |
31/10/2014 |
| Deerfield Private Design Fund III, L.P. |
Delaware |
0 |
876391 |
0 |
0 |
876391 |
5.84 % |
27/10/2014 |
| Deerfield Mgmt III, L.P. |
Delaware |
0 |
876391 |
0 |
0 |
876391 |
5.84 % |
27/10/2014 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
378716 |
0 |
0 |
378716 |
2.53 % |
27/10/2014 |
| James E. Flynn |
United States |
0 |
1255107 |
0 |
0 |
1255107 |
8.37 % |
27/10/2014 |
| Deerfield Special Situations International Master Fund, L.P. |
British Virgin Islands |
0 |
170371 |
0 |
0 |
170371 |
1.14 % |
27/10/2014 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
1255107 |
0 |
0 |
1255107 |
8.37 % |
27/10/2014 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
208345 |
0 |
0 |
208345 |
1.39 % |
27/10/2014 |