Adam Morgan |
USA |
0 |
2059000 |
0 |
2059000 |
2059000 |
5.9 % |
17/12/2024 |
Balaji Venkataraman |
USA |
0 |
2059000 |
0 |
2059000 |
2059000 |
5.9 % |
17/12/2024 |
Velan Horizon GP LLC |
DELAWARE |
0 |
5000 |
0 |
5000 |
5000 |
0 % |
17/12/2024 |
Velan Capital Holdings LLC |
DELAWARE |
0 |
2054000 |
0 |
2054000 |
2054000 |
5.9 % |
17/12/2024 |
Velan Capital Investment Management LP |
DELAWARE |
0 |
2059000 |
0 |
2059000 |
2059000 |
5.9 % |
17/12/2024 |
Velan Capital Management LLC |
DELAWARE |
0 |
2059000 |
0 |
2059000 |
2059000 |
5.9 % |
17/12/2024 |
Velan Capital Master Fund LP |
CAYMAN ISLANDS |
0 |
2054000 |
0 |
2054000 |
2054000 |
5.9 % |
17/12/2024 |
Velan Horizon Fund LP |
DELAWARE |
0 |
5000 |
0 |
5000 |
5000 |
0 % |
17/12/2024 |
Opaleye Management, Inc. |
Massachusetts |
0 |
1681154 |
0 |
1681154 |
1681154 |
8.15 % |
18/11/2024 |
Woodline Partners LP |
Delaware |
1576567 |
0 |
1576567 |
0 |
1576567 |
7.4 % |
14/11/2024 |
CVI Investments, Inc. |
Cayman Islands |
0 |
600380 |
0 |
600380 |
600380 |
2.8 % |
14/11/2024 |
Heights Capital Management, Inc. |
Delaware |
0 |
600380 |
0 |
600380 |
600380 |
2.8 % |
14/11/2024 |
OrbiMed Advisors LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2024 |
OrbiMed Capital LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2024 |
OrbiMed Advisors LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2024 |
OrbiMed Capital LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2024 |
OrbiMed Capital LLC |
Delaware |
671741 |
0 |
671741 |
0 |
671741 |
6 % |
14/02/2023 |
OrbiMed Advisors LLC |
Delaware |
0 |
158900 |
0 |
158900 |
158900 |
1.4 % |
14/02/2023 |
OrbiMed Advisors LLC |
Delaware |
0 |
158900 |
0 |
158900 |
158900 |
1.4 % |
14/02/2023 |
OrbiMed Capital LLC |
Delaware |
671741 |
0 |
671741 |
0 |
671741 |
6 % |
14/02/2023 |
Rock Springs Capital Management LP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
Rock Springs Capital Master Fund LP |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
Rock Springs Capital LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
Neil Shahrestani |
United States |
0 |
279256 |
0 |
279256 |
279256 |
2.5 % |
14/02/2022 |
Chart Westcott |
United States |
0 |
279256 |
0 |
279256 |
279256 |
2.5 % |
14/02/2022 |
Ikarian Capital, LLC |
Delaware |
0 |
279256 |
0 |
279256 |
279256 |
2.5 % |
14/02/2022 |
OrbiMed Advisors LLC |
Delaware |
0 |
158900 |
0 |
158900 |
158900 |
1.4 % |
11/02/2022 |
OrbiMed Advisors LLC |
Delaware |
0 |
158900 |
0 |
158900 |
158900 |
1.4 % |
11/02/2022 |
OrbiMed Capital LLC |
Delaware |
671741 |
0 |
671741 |
0 |
671741 |
6 % |
11/02/2022 |
OrbiMed Capital LLC |
Delaware |
671741 |
0 |
671741 |
0 |
671741 |
6 % |
11/02/2022 |
Rock Springs Capital Management LP |
Delaware |
0 |
643200 |
0 |
643200 |
0 |
5.74 % |
16/02/2021 |
Rock Springs Capital Master Fund LP |
Cayman Islands |
0 |
625000 |
0 |
625000 |
625000 |
5.57 % |
16/02/2021 |
Rock Springs Capital Master Fund LP |
Cayman Islands |
0 |
625000 |
0 |
625000 |
0 |
5.57 % |
16/02/2021 |
Rock Springs Capital LLC |
Delaware |
0 |
643200 |
0 |
643200 |
0 |
5.74 % |
16/02/2021 |
Rock Springs Capital LLC |
Delaware |
0 |
643200 |
0 |
643200 |
643200 |
5.74 % |
16/02/2021 |
Rock Springs Capital Management LP |
Delaware |
0 |
643200 |
0 |
643200 |
643200 |
5.74 % |
16/02/2021 |
Neil Shahrestani |
United States of America |
0 |
649542 |
0 |
649542 |
649542 |
5.8 % |
12/02/2021 |
Ikarian Healthcare Fund GP, L.P. |
Delaware |
0 |
530427 |
0 |
530427 |
530427 |
4.7 % |
12/02/2021 |
Ikarian Healthcare Master Fund, L.P. |
Cayman Islands |
0 |
530427 |
0 |
530427 |
530427 |
4.7 % |
12/02/2021 |
Ikarian Capital, LLC |
Delaware |
0 |
649542 |
0 |
649542 |
649542 |
5.8 % |
12/02/2021 |
Chart Westcott |
United States |
0 |
649542 |
0 |
649542 |
649542 |
5.8 % |
12/02/2021 |
Rock Springs Capital LLC |
Delaware |
0 |
643622 |
0 |
643622 |
0 |
6.16 % |
02/10/2020 |
Rock Springs Capital Management LP |
Delaware |
0 |
643622 |
0 |
643622 |
0 |
6.16 % |
02/10/2020 |
Rock Springs Capital LLC |
Delaware |
0 |
643622 |
0 |
643622 |
0 |
6.16 % |
02/10/2020 |
Rock Springs Capital Master Fund LP |
Cayman Islands |
0 |
625000 |
0 |
625000 |
0 |
5.98 % |
02/10/2020 |
Rock Springs Capital Management LP |
Delaware |
0 |
643622 |
0 |
643622 |
0 |
6.16 % |
02/10/2020 |
Rock Springs Capital Master Fund LP |
Cayman Islands |
0 |
625000 |
0 |
625000 |
0 |
5.98 % |
02/10/2020 |
Perceptive Life Sciences Master Fund, Ltd. |
Cayman Islands |
0 |
608544 |
0 |
608544 |
608544 |
5.8 % |
01/10/2020 |
Perceptive Advisors LLC |
Delaware |
0 |
608544 |
0 |
608544 |
608544 |
5.8 % |
01/10/2020 |
Joseph Edelman |
United States of America |
0 |
608544 |
0 |
608544 |
608544 |
5.8 % |
01/10/2020 |
Chart Westcott |
United States |
0 |
307308 |
0 |
307308 |
307308 |
5.3 % |
21/02/2020 |
Neil Shahrestani |
United States of America |
0 |
307308 |
0 |
307308 |
307308 |
5.3 % |
21/02/2020 |
Ikarian Capital, LLC |
Delaware |
0 |
307308 |
0 |
307308 |
307308 |
5.3 % |
21/02/2020 |
Ikarian Healthcare Master Fund, L.P. |
Cayman Islands |
0 |
260171 |
0 |
260171 |
260171 |
4.5 % |
21/02/2020 |
Ikarian Healthcare Fund GP, L.P. |
Delaware |
0 |
260171 |
0 |
260171 |
260171 |
4.5 % |
21/02/2020 |
Mitch Mumma |
United States America |
0 |
32510 |
0 |
32510 |
32510 |
1 % |
14/02/2020 |
Dennis Dougherty |
United States America |
0 |
32510 |
0 |
32510 |
32510 |
1 % |
14/02/2020 |
Intersouth Partners VI, L.P. |
Delaware |
0 |
32510 |
0 |
32510 |
32510 |
1 % |
14/02/2020 |
Intersouth Associates VI, LLC |
Delaware |
0 |
32510 |
0 |
32510 |
32510 |
1 % |
14/02/2020 |
DRW Management LLC |
Delaware |
448751 |
0 |
448751 |
0 |
448751 |
7.68 % |
16/01/2020 |
DRW Venture Capital LLC |
Delaware |
448751 |
0 |
448751 |
0 |
448751 |
7.68 % |
16/01/2020 |
Donald R. Wilson, Jr. |
United States |
448751 |
0 |
448751 |
0 |
448751 |
7.68 % |
16/01/2020 |
DRW Holdings, LLC |
Delaware |
448751 |
0 |
448751 |
0 |
448751 |
7.68 % |
16/01/2020 |
Ronald M. Hunt |
United States citizen |
|
6 |
|
8 |
1523200 |
8.6 % |
06/11/2018 |
New Leaf BPO Management II, L.L.C. |
Delaware |
1523200 |
5 |
1523200 |
7 |
1523200 |
8.6 % |
06/11/2018 |
New Leaf BPO Associates II, L.P. |
Delaware |
1523200 |
5 |
1523200 |
7 |
1523200 |
8.6 % |
06/11/2018 |
New Leaf Biopharma Opportunities II, L.P. |
Delaware |
1523200 |
5 |
1523200 |
7 |
1523200 |
8.6 % |
06/11/2018 |
Vijay K. Lathi |
United States citizen |
|
6 |
|
8 |
1523200 |
8.6 % |
06/11/2018 |
Isaac Manke |
United States citizen |
|
6 |
|
8 |
1523200 |
8.6 % |
06/11/2018 |
Liam T. Ratcliffe |
United States citizen |
|
6 |
|
8 |
1523200 |
8.6 % |
06/11/2018 |
Intersouth Associates VI, LLC |
Delaware |
0 |
1300433 |
0 |
1300433 |
1300433 |
7.4 % |
13/02/2018 |
Dennis Dougherty |
United States America |
0 |
1300433 |
0 |
1300433 |
1300433 |
7.4 % |
13/02/2018 |
Mitch Mumma |
United States America |
0 |
1300433 |
0 |
1300433 |
1300433 |
7.4 % |
13/02/2018 |
Intersouth Partners VI, L.P. |
Delaware |
0 |
1300433 |
0 |
1300433 |
1300433 |
7.4 % |
13/02/2018 |
Deerfield Management Company, L.P. |
Delaware |
0 |
1224899 |
0 |
1224899 |
1224899 |
7.3 % |
02/05/2017 |
Deerfield International Master Fund, L.P. |
British Virgin Islands |
0 |
110557 |
0 |
110557 |
110557 |
0.66 % |
02/05/2017 |
Deerfield Partners, L.P. |
Delaware |
0 |
86867 |
0 |
86867 |
86867 |
0.52 % |
02/05/2017 |
Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
149676 |
0 |
149676 |
149676 |
0.89 % |
02/05/2017 |
Deerfield Mgmt III, L.P. |
Delaware |
0 |
877799 |
0 |
877799 |
877799 |
5.23 % |
02/05/2017 |
James E. Flynn |
United States |
0 |
1224899 |
0 |
1224899 |
1224899 |
7.3 % |
02/05/2017 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
347100 |
0 |
347100 |
347100 |
2.07 % |
02/05/2017 |
Deerfield Private Design Fund III, L.P. |
Delaware |
0 |
877799 |
0 |
877799 |
877799 |
5.23 % |
02/05/2017 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
1212603 |
0 |
1212603 |
1212603 |
7.4 % |
16/02/2016 |
Peter Kolchinsky |
United States |
0 |
1476931 |
0 |
1476931 |
1476931 |
9 % |
16/02/2016 |
RA Capital Management, LLC |
Massachusetts |
0 |
1476931 |
0 |
1476931 |
1476931 |
9 % |
16/02/2016 |
Deerfield Private Design Fund III, L.P. |
British Virgin Islands |
0 |
877799 |
0 |
877799 |
877799 |
5.32 % |
16/02/2016 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
387544 |
0 |
387544 |
387544 |
2.35 % |
16/02/2016 |
Deerfield Mgmt III, L.P. |
Delaware |
0 |
877799 |
0 |
877799 |
877799 |
5.32 % |
16/02/2016 |
Deerfield Management Company, L.P. |
Delaware |
0 |
1265343 |
0 |
1265343 |
1265343 |
7.68 % |
16/02/2016 |
Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
387544 |
0 |
387544 |
387544 |
2.35 % |
16/02/2016 |
James E. Flynn |
United States |
0 |
1265343 |
0 |
1265343 |
1265343 |
7.68 % |
16/02/2016 |
Deerfield Special Situations International Master Fund, L.P. |
British Virgin Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
Dennis Dougherty |
United States of America |
0 |
898383 |
0 |
898383 |
898383 |
5.5 % |
07/04/2015 |
Mitch Mumma |
United States of America |
0 |
898383 |
0 |
898383 |
898383 |
5.5 % |
07/04/2015 |
Intersouth Associates VI, LLC |
Delaware |
0 |
898383 |
0 |
898383 |
898383 |
5.5 % |
07/04/2015 |
Intersouth Partners VI, L.P. |
Delaware |
0 |
898383 |
0 |
898383 |
898383 |
5.5 % |
07/04/2015 |
Steven J. Benson |
United States of America |
0 |
1337462 |
0 |
1337462 |
1337462 |
8.1 % |
24/02/2015 |
James A. Counihan |
United States of America |
0 |
1337462 |
0 |
1337462 |
1337462 |
8.1 % |
24/02/2015 |
Brendan O’Leary |
United States of America |
0 |
1337462 |
0 |
1337462 |
1337462 |
8.1 % |
24/02/2015 |
Prism Venture Partners V, LLC |
Delaware |
0 |
1337462 |
0 |
1337462 |
1337462 |
8.1 % |
24/02/2015 |
Prism Venture Partners V, L.P. |
Delaware |
0 |
1337462 |
0 |
1337462 |
1337462 |
8.1 % |
24/02/2015 |
Prism Venture Partners L.P. |
Delaware |
0 |
1337462 |
0 |
1337462 |
1337462 |
8.1 % |
24/02/2015 |
Prism Investment Partners V, L.P. |
Delaware |
0 |
1337462 |
0 |
1337462 |
1337462 |
8.1 % |
24/02/2015 |
S Deerfield Mgmt, L.P. |
Delaware |
0 |
387544 |
0 |
387544 |
387544 |
2.36 % |
17/02/2015 |
S James E. Flynn |
United States |
0 |
1265343 |
0 |
1265343 |
1265343 |
7.69 % |
17/02/2015 |
S Deerfield Special Situations International Master Fund, L.P. |
British Virgin Islands |
0 |
174373 |
0 |
174373 |
174373 |
1.06 % |
17/02/2015 |
S Deerfield Private Design Fund III, L.P. |
Delaware |
0 |
877799 |
0 |
877799 |
877799 |
5.34 % |
17/02/2015 |
S Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
213171 |
0 |
213171 |
213171 |
1.3 % |
17/02/2015 |
S Deerfield Mgmt III, L.P. |
Delaware |
0 |
877799 |
0 |
877799 |
877799 |
5.34 % |
17/02/2015 |
S Deerfield Management Company, L.P. |
Delaware |
0 |
1265343 |
0 |
1265343 |
1265343 |
7.69 % |
17/02/2015 |
James A. Counihan |
United States of America |
0 |
1253886 |
0 |
1253886 |
1253886 |
7.6 % |
12/02/2015 |
Steven J. Benson |
United States of America |
0 |
1253886 |
0 |
1253886 |
1253886 |
7.6 % |
12/02/2015 |
Prism Venture Partners V, LLC |
Delaware |
0 |
1253886 |
0 |
1253886 |
1253886 |
7.6 % |
12/02/2015 |
Prism Investment Partners V, L.P. |
Delaware |
0 |
1253886 |
0 |
1253886 |
1253886 |
7.6 % |
12/02/2015 |
Prism Venture Partners L.P. |
Delaware |
0 |
1253886 |
0 |
1253886 |
1253886 |
7.6 % |
12/02/2015 |
Prism Venture Partners V, L.P. |
Delaware |
0 |
1253886 |
0 |
1253886 |
1253886 |
7.6 % |
12/02/2015 |
Brendan O’Leary |
United States of America |
0 |
1253886 |
0 |
1253886 |
1253886 |
7.6 % |
12/02/2015 |
James Paul Scopa |
United States |
0 |
983381 |
0 |
983381 |
983381 |
6 % |
05/02/2015 |
Vaughn M. Kailian |
United States |
0 |
983381 |
0 |
983381 |
983381 |
6 % |
05/02/2015 |
Ansbert Gadicke |
United States |
0 |
983381 |
0 |
983381 |
983381 |
6 % |
05/02/2015 |
MPM BioVentures IV LLC |
Delaware |
0 |
983381 |
0 |
983381 |
983381 |
6 % |
05/02/2015 |
MPM BioVentures IV GP LLC |
Delaware |
0 |
983381 |
0 |
983381 |
983381 |
6 % |
05/02/2015 |
MPM Bio IV NVS Strategic Fund, L.P. |
Bermuda |
983381 |
0 |
983381 |
0 |
983381 |
6 % |
05/02/2015 |
Luke Evnin |
United States |
0 |
983381 |
0 |
983381 |
983381 |
6 % |
05/02/2015 |
Todd Foley |
United States |
0 |
983381 |
0 |
983381 |
983381 |
6 % |
05/02/2015 |
RA Capital Management, LLC |
Massachusetts |
0 |
1250000 |
0 |
1250000 |
1250000 |
8.3 % |
31/10/2014 |
Peter Kolchinsky |
United States |
0 |
1250000 |
0 |
1250000 |
1250000 |
8.3 % |
31/10/2014 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
1025000 |
0 |
1025000 |
1025000 |
6.8 % |
31/10/2014 |
Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
208345 |
0 |
208345 |
208345 |
1.39 % |
27/10/2014 |
Deerfield Private Design Fund III, L.P. |
Delaware |
0 |
876391 |
0 |
876391 |
876391 |
5.84 % |
27/10/2014 |
Deerfield Special Situations International Master Fund, L.P. |
British Virgin Islands |
0 |
170371 |
0 |
170371 |
170371 |
1.14 % |
27/10/2014 |
James E. Flynn |
United States |
0 |
1255107 |
0 |
1255107 |
1255107 |
8.37 % |
27/10/2014 |
Deerfield Mgmt III, L.P. |
Delaware |
0 |
876391 |
0 |
876391 |
876391 |
5.84 % |
27/10/2014 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
378716 |
0 |
378716 |
378716 |
2.53 % |
27/10/2014 |
Deerfield Management Company, L.P. |
Delaware |
0 |
1255107 |
0 |
1255107 |
1255107 |
8.37 % |
27/10/2014 |