| aMoon Growth Fund Limited Partnership |
Cayman Islands |
0 |
560602 |
0 |
0 |
560602 |
5.21 % |
23/10/2023 |
| aMoon General Partner Ltd. |
Israel |
0 |
560602 |
0 |
0 |
560602 |
5.21 % |
23/10/2023 |
| Dr. Yair C. Schindel |
Israel |
0 |
560602 |
0 |
0 |
560602 |
5.21 % |
23/10/2023 |
| aMoon Growth Fund G.P. Limited Partnership |
Israel |
0 |
560602 |
0 |
0 |
560602 |
5.21 % |
23/10/2023 |
| Israel Biotech Fund II, L.P. |
|
0 |
434783 |
0 |
434783 |
434783 |
8.2 % |
11/09/2023 |
| Israel Biotech Fund GP Partners, L.P. |
|
0 |
1925601 |
0 |
1925601 |
1925601 |
31.3 % |
11/09/2023 |
| Israel Biotech Fund I, L.P. |
|
0 |
1925601 |
0 |
1925601 |
1925601 |
31.3 % |
11/09/2023 |
| Israel Biotech Fund GP Partners II, L.P. |
|
0 |
434783 |
0 |
434783 |
434783 |
8.2 % |
11/09/2023 |
| I.B.F Management Ltd. |
|
0 |
2360384 |
0 |
2360384 |
2360384 |
35.9 % |
11/09/2023 |
| Redmile Group, LLC |
Delaware |
0 |
332353 |
0 |
332353 |
332353 |
6.8 % |
08/02/2023 |
| Jeremy C. Green |
United Kingdom |
0 |
332353 |
0 |
332353 |
332353 |
6.8 % |
08/02/2023 |
| aMoon Growth Fund G.P. Limited Partnership |
Israel |
0 |
560602 |
0 |
0 |
560602 |
12.2 % |
30/01/2023 |
| aMoon Growth Fund Limited Partnership |
Cayman Islands |
0 |
560602 |
0 |
0 |
560602 |
12.2 % |
30/01/2023 |
| Dr. Yair C. Schindel |
Israel |
0 |
560602 |
0 |
0 |
560602 |
12.2 % |
30/01/2023 |
| aMoon General Partner Ltd. |
Israel |
0 |
560602 |
0 |
0 |
560602 |
12.2 % |
30/01/2023 |
| 13-3127734 |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
10/02/2022 |
| 26-0385758 |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
10/02/2022 |
| CVI Investments, Inc. |
Cayman Islands |
0 |
2000000 |
0 |
2000000 |
2000000 |
2.1 % |
16/02/2021 |
| 26-0385758 |
Delaware |
4811211 |
0 |
6069343 |
0 |
6069343 |
6.5 % |
11/02/2021 |
| 13-3127734 |
Delaware |
4811211 |
0 |
6069343 |
0 |
6069343 |
6.5 % |
11/02/2021 |
| Rockledge Capital Corporation |
Texas |
0 |
4594793 |
0 |
4594793 |
4594793 |
6.94 % |
03/08/2020 |
| Lincoln Park Capital, LLC |
Illinois |
0 |
4594793 |
0 |
4594793 |
4594793 |
6.94 % |
03/08/2020 |
| Lincoln Park Capital Fund, LLC |
Illinois |
0 |
4594793 |
0 |
4594793 |
4594793 |
6.94 % |
03/08/2020 |
| Jonathan I. Cope |
United States |
0 |
4594793 |
0 |
0 |
4594793 |
6.94 % |
03/08/2020 |
| Inc. |
Illinois |
0 |
4594793 |
0 |
0 |
4594793 |
6.94 % |
03/08/2020 |
| Joshua B. Scheinfeld |
United States |
0 |
4594793 |
0 |
0 |
4594793 |
6.94 % |
03/08/2020 |
| Altium Growth Fund, LP |
Delaware, United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
| Altium Capital Management, LP |
Delaware, United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
| Altium Growth GP, LLC |
Delaware, United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
| 13-3127734 |
Delaware |
3780083 |
0 |
3780083 |
0 |
3780083 |
7.53 % |
13/02/2020 |
| 26-0385758 |
Delaware |
3780083 |
0 |
3780083 |
0 |
3780083 |
7.53 % |
13/02/2020 |
| CVI Investments, Inc. |
Cayman Islands |
0 |
5000000 |
0 |
5000000 |
5000000 |
8.3 % |
30/01/2020 |
| Heights Capital Management, Inc. |
Delaware |
0 |
5000000 |
0 |
5000000 |
5000000 |
8.3 % |
30/01/2020 |
| Ryan M. Lane |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
21/01/2020 |
| Empery Tax Efficient II, LP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
21/01/2020 |
| Empery Asset Management, LP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
21/01/2020 |
| Martin D. Hoe |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
21/01/2020 |
| Altium Growth Fund, LP |
United States of America |
0 |
2142750 |
0 |
0 |
2142750 |
9.87 % |
31/07/2019 |
| Altium Growth GP, LLC |
United States of America |
0 |
2142750 |
0 |
0 |
2142750 |
9.87 % |
31/07/2019 |
| Altium Capital Management, LP |
United States of America |
0 |
2142750 |
0 |
0 |
2142750 |
9.87 % |
31/07/2019 |
| Ryan M. Lane |
United States |
0 |
600000 |
0 |
0 |
600000 |
7.49 % |
12/04/2019 |
| Empery Asset Management, LP |
Delaware |
0 |
600000 |
0 |
0 |
600000 |
7.49 % |
12/04/2019 |
| Empery Tax Efficient II, LP |
Delaware |
0 |
457521 |
0 |
0 |
457521 |
5.71 % |
12/04/2019 |
| Martin D. Hoe |
United States |
0 |
600000 |
0 |
0 |
600000 |
7.49 % |
12/04/2019 |
| 13G |
Texas |
0 |
600000 |
0 |
600000 |
600000 |
7.5 % |
09/04/2019 |
| 13G |
Texas |
0 |
600000 |
0 |
600000 |
600000 |
7.5 % |
09/04/2019 |
| 13G |
Texas |
0 |
600000 |
0 |
600000 |
600000 |
7.5 % |
09/04/2019 |
| 13G |
Texas |
0 |
600000 |
0 |
600000 |
600000 |
7.5 % |
09/04/2019 |
| 13G |
Texas |
0 |
600000 |
0 |
600000 |
600000 |
7.5 % |
09/04/2019 |
| 13G |
Texas |
0 |
600000 |
0 |
600000 |
600000 |
7.5 % |
09/04/2019 |
| Heights Capital Management, Inc. |
Delaware |
0 |
3545562 |
0 |
3545562 |
3545562 |
4.9 % |
14/02/2019 |
| CVI Investments, Inc. |
Cayman Islands |
0 |
3545562 |
0 |
3545562 |
3545562 |
4.9 % |
14/02/2019 |
| Robert Atchinson |
United States |
0 |
2500000 |
0 |
0 |
2500000 |
3.59 % |
13/02/2019 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
2500000 |
0 |
0 |
2500000 |
3.59 % |
13/02/2019 |
| Phillip Gross |
United States |
0 |
2500000 |
0 |
0 |
2500000 |
3.59 % |
13/02/2019 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
2500000 |
0 |
0 |
2500000 |
3.59 % |
13/02/2019 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
2500000 |
0 |
0 |
2500000 |
3.59 % |
13/02/2019 |
| 10) |
Delaware |
3047446 |
0 |
3047446 |
0 |
3047446 |
4.4 % |
28/12/2018 |
| Heights Capital Management, Inc. |
Delaware |
0 |
4166666 |
0 |
4166666 |
4166666 |
6 % |
14/09/2018 |
| CVI Investments, Inc. |
Cayman Islands |
0 |
4166666 |
0 |
4166666 |
4166666 |
6 % |
14/09/2018 |
| (1) BlackRock, Inc. |
Delaware |
1396923 |
0 |
1396923 |
0 |
1396923 |
2.7 % |
10/07/2018 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
4000000 |
0 |
0 |
4000000 |
9.68 % |
13/02/2018 |
| Robert Atchinson |
United States |
0 |
4000000 |
0 |
0 |
4000000 |
9.68 % |
13/02/2018 |
| Phillip Gross |
United States |
0 |
4000000 |
0 |
0 |
4000000 |
9.68 % |
13/02/2018 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
4000000 |
0 |
0 |
4000000 |
9.68 % |
13/02/2018 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
4000000 |
0 |
0 |
4000000 |
9.68 % |
13/02/2018 |
| (1) BlackRock, Inc. |
Delaware |
2237430 |
0 |
2281216 |
0 |
2281216 |
5.5 % |
29/01/2018 |
| Abigail P. Johnson |
Delaware |
0 |
0 |
614430 |
0 |
614430 |
1.496 % |
09/11/2017 |
| FMR LLC |
Delaware |
250 |
0 |
614430 |
0 |
614430 |
1.496 % |
09/11/2017 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
4700043 |
0 |
0 |
4700043 |
11.45 % |
27/09/2017 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
4700043 |
0 |
0 |
4700043 |
11.45 % |
27/09/2017 |
| Robert Atchinson |
United States |
0 |
4700043 |
0 |
0 |
4700043 |
11.45 % |
27/09/2017 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
4700043 |
0 |
0 |
4700043 |
11.45 % |
27/09/2017 |
| Phillip Gross |
United States |
0 |
4700043 |
0 |
0 |
4700043 |
11.45 % |
27/09/2017 |
| FMR LLC |
Delaware |
72000 |
0 |
4102885 |
0 |
4102885 |
10.297 % |
14/02/2017 |
| Kevin Kotler |
Delaware |
0 |
1519259 |
0 |
1519259 |
1519259 |
3.81 % |
13/02/2017 |
| Broadfin Capital, LLC |
Delaware |
0 |
1519259 |
0 |
1519259 |
1519259 |
3.81 % |
13/02/2017 |
| Broadfin Healthcare Master Fund, Ltd. |
Delaware |
0 |
1519259 |
0 |
1519259 |
1519259 |
3.81 % |
13/02/2017 |
| STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
621505 |
0 |
621505 |
621505 |
1.56 % |
10/02/2017 |
| Sectoral Asset Management Inc. |
Canada |
190251 |
0 |
690074 |
0 |
690074 |
1.7 % |
10/02/2017 |
| Michael L. Sjöström |
Swiss |
190251 |
0 |
690074 |
0 |
690074 |
1.7 % |
10/02/2017 |
| Jérôme G. Pfund |
Swiss |
190251 |
0 |
690074 |
0 |
690074 |
1.7 % |
10/02/2017 |
| 10) |
Delaware |
3047446 |
0 |
3047446 |
0 |
3047446 |
7.6 % |
07/02/2017 |
| (1) BlackRock, Inc. |
Delaware |
2213646 |
0 |
2271463 |
0 |
2271463 |
5.7 % |
30/01/2017 |
| 10) |
Delaware |
0 |
0 |
0 |
0 |
3047446 |
8.9 % |
02/08/2016 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
5939366 |
0 |
0 |
5939366 |
17.8 % |
16/02/2016 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
5939366 |
0 |
0 |
5939366 |
17.8 % |
16/02/2016 |
| Phillip Gross |
United States |
0 |
5939366 |
0 |
0 |
5939366 |
17.8 % |
16/02/2016 |
| Robert Atchinson |
United States |
0 |
5939366 |
0 |
0 |
5939366 |
17.8 % |
16/02/2016 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
5939366 |
0 |
0 |
5939366 |
17.8 % |
16/02/2016 |
| STATE STREET CORPORATION |
BOSTON MASSACHUSETTS |
0 |
1683646 |
0 |
1683646 |
1683646 |
5.1 % |
12/02/2016 |
| Jérôme G. Pfund |
Swiss |
1621215 |
0 |
1790715 |
0 |
1790715 |
5.3 % |
12/02/2016 |
| Sectoral Asset Management Inc. |
Canada |
1621215 |
0 |
1790715 |
0 |
1790715 |
5.3 % |
12/02/2016 |
| Michael L. Sjöström |
Swiss |
1621215 |
0 |
1790715 |
0 |
1790715 |
5.3 % |
12/02/2016 |
| Broadfin Healthcare Master Fund, Ltd. |
Delaware |
0 |
1690517 |
0 |
1690517 |
1690517 |
5.07 % |
11/02/2016 |
| Broadfin Capital, LLC |
Delaware |
0 |
1690517 |
0 |
1690517 |
1690517 |
5.07 % |
11/02/2016 |
| Kevin Kotler |
Delaware |
0 |
1690517 |
0 |
1690517 |
1690517 |
5.07 % |
11/02/2016 |
| Kevin Kotler |
Delaware |
0 |
1655314 |
0 |
1655314 |
1655314 |
5.27 % |
12/08/2015 |
| Broadfin Capital, LLC |
Delaware |
0 |
1655314 |
0 |
1655314 |
1655314 |
5.27 % |
12/08/2015 |
| Broadfin Healthcare Master Fund, Ltd. |
Delaware |
0 |
1655314 |
0 |
1655314 |
1655314 |
5.27 % |
12/08/2015 |
| Phillip Gross |
United States |
0 |
4454604 |
0 |
0 |
4454604 |
18.84 % |
19/12/2014 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
4454604 |
0 |
0 |
4454604 |
18.84 % |
19/12/2014 |
| Robert Atchinson |
United States |
0 |
4454604 |
0 |
0 |
4454604 |
18.84 % |
19/12/2014 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
4454604 |
0 |
0 |
4454604 |
18.84 % |
19/12/2014 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
4454604 |
0 |
0 |
4454604 |
18.84 % |
19/12/2014 |
| Justin Keener |
United States |
803333 |
0 |
803333 |
0 |
803333 |
5.97 % |
30/10/2013 |
| Sabby Healthcare Volatility Master Fund, Ltd. |
Cayman Islands |
0 |
600000 |
0 |
600000 |
600000 |
4.74 % |
24/10/2013 |
| Ironridge Global IV, Ltd. |
United States |
0 |
0 |
32345613 |
0 |
32345613 |
6.9 % |
21/12/2012 |
| Richard H. Kreger |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
21/12/2012 |
| John C. Kirkland |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
21/12/2012 |
| Ironridge Global Partners, LLC |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
21/12/2012 |
| Keith Coulston |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
21/12/2012 |
| Brendan T. O’Neil |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
21/12/2012 |
| 27-0492860 |
Delaware |
11448186 |
0 |
11448186 |
0 |
11448186 |
9.9 % |
16/02/2010 |
| Optimus CG II, Ltd. |
Cayman Islands |
11448186 |
0 |
11448186 |
0 |
11448186 |
9.9 % |
16/02/2010 |
| Centrecourt Asset Management LLC |
United States |
3384196 |
0 |
3384196 |
0 |
3384196 |
3.01 % |
19/05/2009 |
| Richard Smithline |
United States |
3384196 |
0 |
3384196 |
0 |
3384196 |
3.01 % |
19/05/2009 |
| CAMOFI Master LDC |
Cayman Islands |
2724196 |
0 |
2724196 |
0 |
2724196 |
2.42 % |
19/05/2009 |
| CAMHZN Master LDC |
Cayman Islands |
660000 |
0 |
660000 |
0 |
660000 |
0.59 % |
19/05/2009 |
| Centrecourt Asset Management LLC |
United States |
9929385 |
0 |
9929385 |
0 |
9929385 |
8.9 % |
12/02/2009 |
| CAMOFI Master LDC |
Cayman Islands |
8064247 |
0 |
8064247 |
0 |
8064247 |
7.2 % |
12/02/2009 |
| CAMHZN Master LDC |
Cayman Islands |
1865138 |
0 |
1865138 |
0 |
1865138 |
1.7 % |
12/02/2009 |
| Richard Smithline |
United States |
9929385 |
0 |
9929385 |
0 |
9929385 |
8.9 % |
12/02/2009 |
| CAMOFI Master LDC |
Cayman Islands |
20856935 |
0 |
20856935 |
0 |
20856935 |
7.6 % |
07/02/2008 |
| Centrecourt Asset Management LLC |
United States |
26020269 |
0 |
26020269 |
0 |
26020269 |
9.45 % |
07/02/2008 |
| Richard Smithline |
United States |
26020269 |
0 |
26020269 |
0 |
26020269 |
9.45 % |
07/02/2008 |
| CAMHZN Master LDC |
Cayman Islands |
5163334 |
0 |
5163334 |
0 |
5163334 |
1.85 % |
07/02/2008 |
| CAMOFI Master LDC |
Cayman Islands |
20676435 |
0 |
20676435 |
0 |
20676435 |
9.99 % |
25/10/2007 |
| Richard Smithline |
United States |
25839769 |
0 |
25839769 |
0 |
25839769 |
9.99 % |
25/10/2007 |
| Centrecourt Asset Management LLC |
United States |
25839769 |
0 |
25839769 |
0 |
25839769 |
9.99 % |
25/10/2007 |