CymaBay Therapeutics, Inc. CBAY
Trading inactive
| Name of reporting person | Citizenship or organization | Sole voting power | Shared voting power | Sole dispositive power | Shared dispositive power | Amount beneficially owned | Percent of class | Accepted date |
|---|---|---|---|---|---|---|---|---|
| Joseph Edelman | United States of America | 0 | 4024400 | 0 | 4024400 | 4024400 | 3.5 % | 14/02/2024 |
| Perceptive Advisors LLC | Delaware | 0 | 4024400 | 0 | 4024400 | 4024400 | 3.5 % | 14/02/2024 |
| Perceptive Life Sciences Master Fund, Ltd. | Cayman Islands | 0 | 4024400 | 0 | 4024400 | 4024400 | 3.5 % | 14/02/2024 |
| Commodore Capital Master LP | Cayman Islands | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2024 |
| Commodore Capital LP | Delaware, USA | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2024 |
| Janus Henderson Group plc EIN | Jersey, Channel Islands | 0 | 6103797 | 0 | 6103797 | 6103797 | 5.4 % | 14/02/2024 |
| Avoro Capital Advisors LLC | Delaware | 16337739 | 0 | 16337739 | 0 | 16337739 | 9.99 % | 14/02/2024 |
| Behzad Aghazadeh | United States | 16337739 | 0 | 16337739 | 0 | 16337739 | 9.99 % | 14/02/2024 |
| The Vanguard Group | Pennsylvania | 0 | 206107 | 6018677 | 287472 | 6306149 | 5.56 % | 13/02/2024 |
| Chen Yu | United States of America | 0 | 0 | 0 | 0 | 0 | 0 % | 13/02/2024 |
| TCG Crossover Fund I, L.P. | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 13/02/2024 |
| TCG Crossover GP I, LLC | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 13/02/2024 |
| BlackRock, Inc. | Delaware | 9453415 | 0 | 9610239 | 0 | 9610239 | 8.5 % | 25/01/2024 |
| RA Capital Healthcare Fund, L.P. | Delaware | 0 | 6940000 | 0 | 6940000 | 6940000 | 6.2 % | 22/09/2023 |
| Rajeev Shah | United States of America | 0 | 6940000 | 0 | 6940000 | 6940000 | 6.2 % | 22/09/2023 |
| Peter Kolchinsky | United States of America | 0 | 6940000 | 0 | 6940000 | 6940000 | 6.2 % | 22/09/2023 |
| RA Capital Management, L.P. | Delaware | 0 | 6940000 | 0 | 6940000 | 6940000 | 6.2 % | 22/09/2023 |
| RA Capital Healthcare Fund, L.P. | Delaware | 0 | 6940000 | 0 | 6940000 | 6940000 | 6.2 % | 22/09/2023 |
| Rajeev Shah | United States of America | 0 | 6940000 | 0 | 6940000 | 6940000 | 6.2 % | 22/09/2023 |
| Peter Kolchinsky | United States of America | 0 | 6940000 | 0 | 6940000 | 6940000 | 6.2 % | 22/09/2023 |
| RA Capital Management, L.P. | Delaware | 0 | 6940000 | 0 | 6940000 | 6940000 | 6.2 % | 22/09/2023 |
| Adage Capital Partners GP, L.L.C. | Delaware | 0 | 3685625 | 0 | 3685625 | 3685625 | 3.76 % | 11/09/2023 |
| Robert Atchinson | United States | 0 | 3685625 | 0 | 3685625 | 3685625 | 3.76 % | 11/09/2023 |
| Adage Capital Management, L.P. | Delaware | 0 | 3685625 | 0 | 3685625 | 3685625 | 3.76 % | 11/09/2023 |
| Adage Capital Partners, L.P. | Delaware | 0 | 3685625 | 0 | 3685625 | 3685625 | 3.76 % | 11/09/2023 |
| Adage Capital Partners GP, L.L.C. | Delaware | 0 | 3685625 | 0 | 3685625 | 3685625 | 3.76 % | 11/09/2023 |
| Adage Capital Partners, L.P. | Delaware | 0 | 3685625 | 0 | 3685625 | 3685625 | 3.76 % | 11/09/2023 |
| Phillip Gross | United States | 0 | 3685625 | 0 | 3685625 | 3685625 | 3.76 % | 11/09/2023 |
| Adage Capital Management, L.P. | Delaware | 0 | 3685625 | 0 | 3685625 | 3685625 | 3.76 % | 11/09/2023 |
| Robert Atchinson | United States | 0 | 3685625 | 0 | 3685625 | 3685625 | 3.76 % | 11/09/2023 |
| Phillip Gross | United States | 0 | 3685625 | 0 | 3685625 | 3685625 | 3.76 % | 11/09/2023 |
| Perceptive Advisors LLC | Delaware | 0 | 5278962 | 0 | 5278962 | 5278962 | 5.6 % | 10/03/2023 |
| Joseph Edelman | United States of America | 0 | 5278962 | 0 | 5278962 | 5278962 | 5.6 % | 10/03/2023 |
| Joseph Edelman | United States of America | 0 | 5278962 | 0 | 5278962 | 5278962 | 5.6 % | 10/03/2023 |
| Perceptive Life Sciences Master Fund, Ltd. | Cayman Islands | 0 | 5278962 | 0 | 5278962 | 5278962 | 5.6 % | 10/03/2023 |
| Perceptive Advisors LLC | Delaware | 0 | 5278962 | 0 | 5278962 | 5278962 | 5.6 % | 10/03/2023 |
| Perceptive Life Sciences Master Fund, Ltd. | Cayman Islands | 0 | 5278962 | 0 | 5278962 | 5278962 | 5.6 % | 10/03/2023 |
| Commodore Capital LP | Delaware USA | 0 | 5738500 | 0 | 5738500 | 5738500 | 6.8 % | 14/02/2023 |
| Commodore Capital Master LP | Cayman Islands | 0 | 5738500 | 0 | 5738500 | 5738500 | 6.8 % | 14/02/2023 |
| Chen Yu | United States America | 0 | 5905400 | 0 | 5905400 | 5905400 | 6.2 % | 14/02/2023 |
| TCG Crossover Fund I, L.P. | Delaware | 0 | 5905400 | 0 | 5905400 | 5905400 | 6.2 % | 14/02/2023 |
| TCG Crossover GP I, LLC | Delaware | 0 | 5905400 | 0 | 5905400 | 5905400 | 6.2 % | 14/02/2023 |
| Boxer Capital, LLC | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2022 |
| Joe Lewis | United Kingdom | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2022 |
| Boxer Asset Management Inc. | Bahamas | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2022 |
| Commodore Capital Master LP | Cayman Islands | 0 | 5419896 | 0 | 5419896 | 5419896 | 7.8 % | 14/02/2022 |
| Commodore Capital LP | Delaware, USA | 0 | 5419896 | 0 | 5419896 | 5419896 | 7.8 % | 14/02/2022 |
| Behzad Aghazadeh | United States | 12800000 | 0 | 12800000 | 0 | 12800000 | 14.7 % | 11/02/2022 |
| Avoro Capital Advisors LLC | Delaware | 12800000 | 0 | 12800000 | 0 | 12800000 | 14.7 % | 11/02/2022 |
| BlackRock, Inc. | Delaware | 5209702 | 0 | 5324128 | 0 | 5324128 | 6.3 % | 01/02/2022 |
| TCG Crossover Management, LLC | Delaware, United States | 5905400 | 0 | 5905400 | 0 | 5905400 | 7 % | 29/11/2021 |
| TCG Crossover Management, LLC | Delaware, United States | 5905400 | 0 | 5905400 | 0 | 5905400 | 7 % | 29/11/2021 |
| Commodore Capital Master LP | Cayman Islands | 0 | 3529465 | 0 | 3529465 | 3529465 | 5.1 % | 12/07/2021 |
| Commodore Capital LP | Delaware, USA | 0 | 3529465 | 0 | 3529465 | 3529465 | 5.1 % | 12/07/2021 |
| Commodore Capital Master LP | Cayman Islands | 0 | 3529465 | 0 | 3529465 | 3529465 | 5.1 % | 12/07/2021 |
| Commodore Capital LP | Delaware, USA | 0 | 3529465 | 0 | 3529465 | 3529465 | 5.1 % | 12/07/2021 |
| David E. Shaw | United States | 0 | 1256849 | 0 | 1260749 | 1260749 | 1.8 % | 16/02/2021 |
| D. E. Shaw & Co., L.P. | Delaware | 0 | 1256849 | 0 | 1260749 | 1260749 | 1.8 % | 16/02/2021 |
| Foresite Capital Management IV, LLC (“FCM IV”) | 1787094 | 2.6 % | 16/02/2021 | |||||
| James Tananbaum (“Tananbaum”) | 3428898 | 3428898 | 0 % | 16/02/2021 | ||||
| Foresite Capital Fund IV, L.P. (“FCF IV”) | 1787094 | 0 % | 16/02/2021 | |||||
| Foresite Capital Fund III, L.P. (“FCF III”) | 1641804 | 1641804 | 0 % | 16/02/2021 | ||||
| James Tananbaum (“Tananbaum”) | 3428898 | 3428898 | 0 % | 16/02/2021 | ||||
| Foresite Capital Management IV, LLC (“FCM IV”) | 1787094 | 2.6 % | 16/02/2021 | |||||
| Foresite Capital Fund IV, L.P. (“FCF IV”) | 1787094 | 0 % | 16/02/2021 | |||||
| Foresite Capital Management III, LLC (“FCM III”) | 1641804 | 0 % | 16/02/2021 | |||||
| Foresite Capital Fund III, L.P. (“FCF III”) | 1641804 | 1641804 | 0 % | 16/02/2021 | ||||
| Foresite Capital Management III, LLC (“FCM III”) | 1641804 | 0 % | 16/02/2021 | |||||
| The Vanguard Group | Pennsylvania | 0 | 64275 | 3316230 | 110781 | 3427011 | 4.97 % | 10/02/2021 |
| BlackRock, Inc. | Delaware | 5312432 | 0 | 5386244 | 0 | 5386244 | 7.8 % | 29/01/2021 |
| Boxer Capital, LLC | Delaware | 0 | 4000000 | 0 | 4000000 | 4000000 | 5.8 % | 24/09/2020 |
| Joe Lewis | United Kingdom | 0 | 4000000 | 0 | 4000000 | 4000000 | 5.8 % | 24/09/2020 |
| Boxer Asset Management Inc. | Bahamas | 0 | 4000000 | 0 | 4000000 | 4000000 | 5.8 % | 24/09/2020 |
| Joe Lewis | United Kingdom | 0 | 4000000 | 0 | 4000000 | 4000000 | 5.8 % | 24/09/2020 |
| Boxer Capital, LLC | Delaware | 0 | 4000000 | 0 | 4000000 | 4000000 | 5.8 % | 24/09/2020 |
| Boxer Asset Management Inc. | Bahamas | 0 | 4000000 | 0 | 4000000 | 4000000 | 5.8 % | 24/09/2020 |
| Behzad Aghazadeh | United States | 10300000 | 0 | 10300000 | 0 | 10300000 | 14.95 % | 01/09/2020 |
| Avoro Capital Advisors LLC | Delaware | 10300000 | 0 | 10300000 | 0 | 10300000 | 14.95 % | 01/09/2020 |
| David E. Shaw | United States | 0 | 3388012 | 0 | 3449612 | 3449612 | 5 % | 05/06/2020 |
| D. E. Shaw & Co., L.P. | Delaware | 0 | 3388012 | 0 | 3449612 | 3449612 | 5 % | 05/06/2020 |
| D. E. Shaw & Co., L.P. | Delaware | 0 | 3388012 | 0 | 3449612 | 3449612 | 5 % | 05/06/2020 |
| David E. Shaw | United States | 0 | 3388012 | 0 | 3449612 | 3449612 | 5 % | 05/06/2020 |
| Point72 Hong Kong Limited | Hong Kong | 0 | 2361 | 0 | 2361 | 2361 | 0.1 % | 14/02/2020 |
| Cubist Systematic Strategies, LLC | Delaware | 0 | 21021 | 0 | 21021 | 21021 | 0.1 % | 14/02/2020 |
| Cubist Systematic Strategies, LLC | Delaware | 0 | 21021 | 0 | 21021 | 21021 | 0.1 % | 14/02/2020 |
| Point72 Capital Advisors, Inc. | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2020 |
| Steven A. Cohen | United States | 0 | 23382 | 0 | 23382 | 23382 | 0.1 % | 14/02/2020 |
| Point72 Hong Kong Limited | Hong Kong | 0 | 2361 | 0 | 2361 | 2361 | 0.1 % | 14/02/2020 |
| Point72 Asset Management, L.P. | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2020 |
| Point72 Asset Management, L.P. | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2020 |
| Point72 Capital Advisors, Inc. | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2020 |
| Steven A. Cohen | United States | 0 | 23382 | 0 | 23382 | 23382 | 0.1 % | 14/02/2020 |
| Perceptive Life Sciences Master Fund, Ltd. | Cayman Islands | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2020 |
| Joseph Edelman | United States of America | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2020 |
| Perceptive Advisors LLC | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2020 |
| Baker Bros. Advisors | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2020 |
| Baker Bros. Advisors LP | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2020 |
| Baker Bros. Advisors LP | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2020 |
| Baker Bros. Advisors | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2020 |
| Julian C. Baker | United States | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2020 |
| Felix J. Baker | United States | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2020 |
| Felix J. Baker | United States | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2020 |
| Julian C. Baker | United States | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2020 |
| Citadel Securities LLC | Delaware | 0 | 315548 | 0 | 315548 | 315548 | 0.5 % | 14/02/2020 |
| Citadel Securities GP LLC | Delaware | 0 | 523033 | 0 | 523033 | 523033 | 0.8 % | 14/02/2020 |
| Kenneth Griffin | U.S. Citizen | 0 | 2934588 | 0 | 2934588 | 2934588 | 4.3 % | 14/02/2020 |
| CALC IV LP | Delaware | 0 | 523033 | 0 | 523033 | 523033 | 0.8 % | 14/02/2020 |
| Citadel GP LLC | Delaware | 0 | 2411555 | 0 | 2411555 | 2411555 | 3.5 % | 14/02/2020 |
| Citadel Advisors Holdings LP | Delaware | 0 | 2411555 | 0 | 2411555 | 2411555 | 3.5 % | 14/02/2020 |
| Citadel Advisors LLC | Delaware | 0 | 2411555 | 0 | 2411555 | 2411555 | 3.5 % | 14/02/2020 |
| Newtyn Management, LLC | New York | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2020 |
| Newtyn Management, LLC | New York | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2020 |
| Behzad Aghazadeh | United States | 5500000 | 0 | 5500000 | 0 | 5500000 | 8 % | 14/02/2020 |
| Avoro Capital Advisors LLC | Delaware | 5500000 | 0 | 5500000 | 0 | 5500000 | 8 % | 14/02/2020 |
| James Tananbaum | United States | 3819726 | 5 | 3819726 | 7 | 3819726 | 5.6 % | 13/02/2020 |
| The Vanguard Group | Pennsylvania | 144353 | 4096 | 3548387 | 142938 | 3691325 | 5.37 % | 11/02/2020 |
| The Vanguard Group | Pennsylvania | 144353 | 4096 | 3548387 | 142938 | 3691325 | 5.37 % | 11/02/2020 |
| BlackRock, Inc. | Delaware | 5483001 | 0 | 5589851 | 0 | 5589851 | 8.1 % | 05/02/2020 |
| Integrated Core Strategies (US) LLC | 1723630 | 2.5 % | 23/01/2020 | |||||
| Integrated Assets II LLC | 1256191 | 1.8 % | 23/01/2020 | |||||
| Integrated Assets, Ltd. | 13824 | 0 % | 23/01/2020 | |||||
| Israel A. Englander | 2993645 | 4.4 % | 23/01/2020 | |||||
| Millennium International Management LP | 1270015 | 1.8 % | 23/01/2020 | |||||
| Millennium International Management LP | 1270015 | 1.8 % | 23/01/2020 | |||||
| Millennium Group Management LLC | 2993645 | 4.4 % | 23/01/2020 | |||||
| Millennium Management LLC | 2993645 | 4.4 % | 23/01/2020 | |||||
| Israel A. Englander | 2993645 | 4.4 % | 23/01/2020 | |||||
| Integrated Assets II LLC | 1256191 | 1.8 % | 23/01/2020 | |||||
| Integrated Assets, Ltd. | 13824 | 0 % | 23/01/2020 | |||||
| Millennium Management LLC | 2993645 | 4.4 % | 23/01/2020 | |||||
| Integrated Core Strategies (US) LLC | 1723630 | 2.5 % | 23/01/2020 | |||||
| Millennium Group Management LLC | 2993645 | 4.4 % | 23/01/2020 | |||||
| Citadel Securities LLC | Delaware | 0 | 463390 | 0 | 463390 | 463390 | 0.7 % | 20/12/2019 |
| Kenneth Griffin | U.S. Citizen | 0 | 3092929 | 0 | 3092929 | 3092929 | 4.5 % | 20/12/2019 |
| Citadel Securities GP LLC | Delaware | 0 | 681374 | 0 | 681374 | 681374 | 1 % | 20/12/2019 |
| CALC IV LP | Delaware | 0 | 681374 | 0 | 681374 | 681374 | 1 % | 20/12/2019 |
| Citadel Securities LLC | Delaware | 0 | 463390 | 0 | 463390 | 463390 | 0.7 % | 20/12/2019 |
| Citadel GP LLC | Delaware | 0 | 2411555 | 0 | 2411555 | 2411555 | 3.5 % | 20/12/2019 |
| Citadel Advisors Holdings LP | Delaware | 0 | 2411555 | 0 | 2411555 | 2411555 | 3.5 % | 20/12/2019 |
| Citadel Advisors LLC | Delaware | 0 | 2411555 | 0 | 2411555 | 2411555 | 3.5 % | 20/12/2019 |
| Kenneth Griffin | U.S. Citizen | 0 | 3092929 | 0 | 3092929 | 3092929 | 4.5 % | 20/12/2019 |
| Citadel Securities GP LLC | Delaware | 0 | 681374 | 0 | 681374 | 681374 | 1 % | 20/12/2019 |
| CALC IV LP | Delaware | 0 | 681374 | 0 | 681374 | 681374 | 1 % | 20/12/2019 |
| Citadel GP LLC | Delaware | 0 | 2411555 | 0 | 2411555 | 2411555 | 3.5 % | 20/12/2019 |
| Citadel Advisors Holdings LP | Delaware | 0 | 2411555 | 0 | 2411555 | 2411555 | 3.5 % | 20/12/2019 |
| Citadel Advisors LLC | Delaware | 0 | 2411555 | 0 | 2411555 | 2411555 | 3.5 % | 20/12/2019 |
| Newtyn Management, LLC | New York | 3698061 | 0 | 3698061 | 0 | 3698061 | 5.4 % | 13/12/2019 |
| Newtyn Management, LLC | New York | 3698061 | 0 | 3698061 | 0 | 3698061 | 5.4 % | 13/12/2019 |
| Integrated Core Strategies (US) LLC | 3698225 | 5.4 % | 01/08/2019 | |||||
| Millennium Management LLC | 3698225 | 5.4 % | 01/08/2019 | |||||
| Integrated Core Strategies (US) LLC | 3698225 | 5.4 % | 01/08/2019 | |||||
| Millennium Group Management LLC | 3698225 | 5.4 % | 01/08/2019 | |||||
| Israel A. Englander | 3698225 | 5.4 % | 01/08/2019 | |||||
| Millennium Group Management LLC | 3698225 | 5.4 % | 01/08/2019 | |||||
| Millennium Management LLC | 3698225 | 5.4 % | 01/08/2019 | |||||
| Israel A. Englander | 3698225 | 5.4 % | 01/08/2019 | |||||
| Steven A. Cohen | United States | 0 | 4329742 | 0 | 4329742 | 4329742 | 6.3 % | 07/06/2019 |
| Point72 Hong Kong Limited | Hong Kong | 0 | 747 | 0 | 747 | 747 | 0.1 % | 07/06/2019 |
| Cubist Systematic Strategies, LLC | Delaware | 0 | 21095 | 0 | 21095 | 21095 | 0.1 % | 07/06/2019 |
| Point72 Capital Advisors, Inc. | Delaware | 0 | 4307900 | 0 | 4307900 | 4307900 | 6.3 % | 07/06/2019 |
| Point72 Asset Management, L.P. | Delaware | 0 | 4307900 | 0 | 4307900 | 4307900 | 6.3 % | 07/06/2019 |
| Steven A. Cohen | United States | 0 | 4329742 | 0 | 4329742 | 4329742 | 6.3 % | 07/06/2019 |
| Point72 Hong Kong Limited | Hong Kong | 0 | 747 | 0 | 747 | 747 | 0.1 % | 07/06/2019 |
| Cubist Systematic Strategies, LLC | Delaware | 0 | 21095 | 0 | 21095 | 21095 | 0.1 % | 07/06/2019 |
| Point72 Capital Advisors, Inc. | Delaware | 0 | 4307900 | 0 | 4307900 | 4307900 | 6.3 % | 07/06/2019 |
| Point72 Asset Management, L.P. | Delaware | 0 | 4307900 | 0 | 4307900 | 4307900 | 6.3 % | 07/06/2019 |
| Perceptive Life Sciences Master Fund, Ltd. | Cayman Islands | 0 | 4242821 | 0 | 4242821 | 4242821 | 6.3 % | 11/03/2019 |
| Perceptive Advisors LLC | Delaware | 0 | 4242821 | 0 | 4242821 | 4242821 | 6.3 % | 11/03/2019 |
| Joseph Edelman | United States of America | 0 | 4242821 | 0 | 4242821 | 4242821 | 6.3 % | 11/03/2019 |
| Perceptive Life Sciences Master Fund, Ltd. | Cayman Islands | 0 | 2462821 | 0 | 2462821 | 2462821 | 4.1 % | 14/02/2019 |
| Joseph Edelman | United States of America | 0 | 2462821 | 0 | 2462821 | 2462821 | 4.1 % | 14/02/2019 |
| Perceptive Advisors LLC | Delaware | 0 | 2462821 | 0 | 2462821 | 2462821 | 4.1 % | 14/02/2019 |
| Baker Bros. Advisors | Delaware | 4917700 | 0 | 4917700 | 0 | 4917700 | 8.3 % | 13/02/2019 |
| Felix J. Baker | United States | 4917700 | 0 | 4917700 | 0 | 4917700 | 8.3 % | 13/02/2019 |
| Julian C. Baker | United States | 4917700 | 0 | 4917700 | 0 | 4917700 | 8.3 % | 13/02/2019 |
| Julian C. Baker | United States | 4917700 | 0 | 4917700 | 0 | 4917700 | 8.3 % | 13/02/2019 |
| Baker Bros. Advisors LP | Delaware | 4917700 | 0 | 4917700 | 0 | 4917700 | 8.3 % | 13/02/2019 |
| Baker Bros. Advisors LP | Delaware | 4917700 | 0 | 4917700 | 0 | 4917700 | 8.3 % | 13/02/2019 |
| Baker Bros. Advisors | Delaware | 4917700 | 0 | 4917700 | 0 | 4917700 | 8.3 % | 13/02/2019 |
| Felix J. Baker | United States | 4917700 | 0 | 4917700 | 0 | 4917700 | 8.3 % | 13/02/2019 |
| Adage Capital Partners, L.P. | Delaware | 0 | 2160150 | 0 | 2160150 | 2160150 | 3.63 % | 13/02/2019 |
| Phillip Gross | United States | 0 | 2160150 | 0 | 2160150 | 2160150 | 3.63 % | 13/02/2019 |
| Robert Atchinson | United States | 0 | 2160150 | 0 | 2160150 | 2160150 | 3.63 % | 13/02/2019 |
| Adage Capital Advisors, L.L.C. | Delaware | 0 | 2160150 | 0 | 2160150 | 2160150 | 3.63 % | 13/02/2019 |
| Adage Capital Partners GP, L.L.C. | Delaware | 0 | 2160150 | 0 | 2160150 | 2160150 | 3.63 % | 13/02/2019 |
| Adage Capital Partners, L.P. | Delaware | 0 | 2160150 | 0 | 2160150 | 2160150 | 3.63 % | 13/02/2019 |
| Adage Capital Partners GP, L.L.C. | Delaware | 0 | 2160150 | 0 | 2160150 | 2160150 | 3.63 % | 13/02/2019 |
| Adage Capital Advisors, L.L.C. | Delaware | 0 | 2160150 | 0 | 2160150 | 2160150 | 3.63 % | 13/02/2019 |
| Robert Atchinson | United States | 0 | 2160150 | 0 | 2160150 | 2160150 | 3.63 % | 13/02/2019 |
| Phillip Gross | United States | 0 | 2160150 | 0 | 2160150 | 2160150 | 3.63 % | 13/02/2019 |
| Foresite Capital Management IV, LLC | Delaware | 2631258 | 2631258 | 2631258 | 2631258 | 2631258 | 4.4 % | 13/02/2019 |
| Foresite Capital Fund IV, L.P. | Delaware | 2631258 | 2631258 | 2631258 | 2631258 | 2631258 | 4.4 % | 13/02/2019 |
| Foresite Capital Fund III, L.P. | Delaware | 1587101 | 1587101 | 1587101 | 1587101 | 1587101 | 2.7 % | 13/02/2019 |
| Foresite Capital Management III, LLC | Delaware | 1587101 | 1587101 | 1587101 | 1587101 | 1587101 | 2.7 % | 13/02/2019 |
| James Tananbaum | United States | 4218359 | 4218359 | 4218359 | 4218359 | 4218359 | 7.1 % | 13/02/2019 |
| Abigail P. Johnson | United States of America | 0 | 0 | 547528 | 0 | 547528 | 0.921 % | 13/02/2019 |
| FMR LLC | Delaware | 424828 | 0 | 547528 | 0 | 547528 | 0.921 % | 13/02/2019 |
| BlackRock, Inc. | Delaware | 5039465 | 0 | 5161581 | 0 | 5161581 | 8.7 % | 07/02/2019 |
| Abigail P. Johnson | United States of America | 0 | 0 | 3234590 | 0 | 3234590 | 5.503 % | 11/06/2018 |
| FMR LLC | Delaware | 952090 | 0 | 3234590 | 0 | 3234590 | 5.503 % | 11/06/2018 |
| FMR LLC | Delaware | 952090 | 0 | 3234590 | 0 | 3234590 | 5.503 % | 11/06/2018 |
| Abigail P. Johnson | United States of America | 0 | 0 | 3234590 | 0 | 3234590 | 5.503 % | 11/06/2018 |
| Abingworth Bioequities Master Fund Limited | Cayman Islands | 0 | 0 | 0 | 0 | 597332 | 1.4 % | 14/02/2018 |
| Abingworth LLP | England | 0 | 1147077 | 0 | 1147077 | 1147077 | 2.6 % | 14/02/2018 |
| Abingworth Bioventures VI, LP | England | 0 | 549745 | 0 | 549745 | 549745 | 1.3 % | 14/02/2018 |
| Baker Bros. Advisors LP | Delaware | 2991775 | 0 | 2991775 | 0 | 2991775 | 6.8 % | 13/02/2018 |
| Julian C. Baker | United States | 2991775 | 0 | 2991775 | 0 | 2991775 | 6.8 % | 13/02/2018 |
| Felix J. Baker | United States | 2991775 | 0 | 2991775 | 0 | 2991775 | 6.8 % | 13/02/2018 |
| Julian C. Baker | United States | 2991775 | 0 | 2991775 | 0 | 2991775 | 6.8 % | 13/02/2018 |
| Baker Bros. Advisors LP | Delaware | 2991775 | 0 | 2991775 | 0 | 2991775 | 6.8 % | 13/02/2018 |
| Baker Bros. Advisors LLC | Delaware | 2991775 | 0 | 2991775 | 0 | 2991775 | 6.8 % | 13/02/2018 |
| Felix J. Baker | United States | 2991775 | 0 | 2991775 | 0 | 2991775 | 6.8 % | 13/02/2018 |
| Baker Bros. Advisors | Delaware | 2991775 | 0 | 2991775 | 0 | 2991775 | 6.8 % | 13/02/2018 |
| Adage Capital Partners, L.P. | Delaware | 0 | 3279526 | 0 | 3279526 | 3279526 | 7.48 % | 13/02/2018 |
| Adage Capital Advisors, L.L.C. | Delaware | 0 | 3279526 | 0 | 3279526 | 3279526 | 7.48 % | 13/02/2018 |
| Robert Atchinson | United States | 0 | 3279526 | 0 | 3279526 | 3279526 | 7.48 % | 13/02/2018 |
| Phillip Gross | United States | 0 | 3279526 | 0 | 3279526 | 3279526 | 7.48 % | 13/02/2018 |
| Adage Capital Advisors, L.L.C. | Delaware | 0 | 3279526 | 0 | 3279526 | 3279526 | 7.48 % | 13/02/2018 |
| Robert Atchinson | United States | 0 | 3279526 | 0 | 3279526 | 3279526 | 7.48 % | 13/02/2018 |
| Phillip Gross | United States | 0 | 3279526 | 0 | 3279526 | 3279526 | 7.48 % | 13/02/2018 |
| Adage Capital Partners GP, L.L.C. | Delaware | 0 | 3279526 | 0 | 3279526 | 3279526 | 7.48 % | 13/02/2018 |
| Adage Capital Partners, L.P. | Delaware | 0 | 3279526 | 0 | 3279526 | 3279526 | 7.48 % | 13/02/2018 |
| Adage Capital Partners GP, L.L.C. | Delaware | 0 | 3279526 | 0 | 3279526 | 3279526 | 7.48 % | 13/02/2018 |
| Foresite Capital Fund IV, L.P. | Delaware | 2254502 | 2254502 | 2254502 | 2254502 | 2254502 | 5.1 % | 13/02/2018 |
| Foresite Capital Management IV, LLC | Delaware | 2254502 | 2254502 | 2254502 | 2254502 | 2254502 | 5.1 % | 13/02/2018 |
| James Tananbaum | United States | 2854502 | 2854502 | 2854502 | 2854502 | 2854502 | 6.5 % | 13/02/2018 |
| Foresite Capital Fund III, L.P. | Delaware | 600000 | 600000 | 600000 | 600000 | 600000 | 1.4 % | 13/02/2018 |
| Foresite Capital Management III, LLC | Delaware | 600000 | 600000 | 600000 | 600000 | 600000 | 1.4 % | 13/02/2018 |
| Abigail P. Johnson | United States of America | 0 | 0 | 5836913 | 0 | 5836913 | 10.527 % | 12/02/2018 |
| FMR LLC | Delaware | 438700 | 0 | 5836913 | 0 | 5836913 | 10.527 % | 12/02/2018 |
| FMR LLC | Delaware | 283800 | 0 | 2327520 | 0 | 2327520 | 5.306 % | 09/02/2018 |
| Abigail P. Johnson | United States of America | 0 | 0 | 2327520 | 0 | 2327520 | 5.306 % | 09/02/2018 |
| Perceptive Advisors LLC | Delaware | 0 | 2685882 | 0 | 2685882 | 2685882 | 6.1 % | 14/11/2017 |
| Joseph Edelman | United States of America | 0 | 2685882 | 0 | 2685882 | 2685882 | 6.1 % | 14/11/2017 |
| Perceptive Life Sciences Master Fund, Ltd. | Cayman Islands | 0 | 2685882 | 0 | 2685882 | 2685882 | 6.1 % | 14/11/2017 |
| Foresite Capital Management IV, LLC | Delaware | 2091792 | 2091792 | 2091792 | 2091792 | 2091792 | 4.7 % | 06/11/2017 |
| Foresite Capital Fund III, L.P. | Delaware | 600000 | 600000 | 600000 | 600000 | 600000 | 1.4 % | 06/11/2017 |
| Foresite Capital Management III, LLC | Delaware | 600000 | 600000 | 600000 | 600000 | 600000 | 1.4 % | 06/11/2017 |
| Foresite Capital Fund IV, L.P. | Delaware | 2091792 | 2091792 | 2091792 | 2091792 | 2091792 | 4.7 % | 06/11/2017 |
| Foresite Capital Management IV, LLC | Delaware | 2091792 | 2091792 | 2091792 | 2091792 | 2091792 | 4.7 % | 06/11/2017 |
| James Tananbaum | United States | 2691792 | 2691792 | 2691792 | 2691792 | 2691792 | 6.2 % | 06/11/2017 |
| Foresite Capital Fund III, L.P. | Delaware | 600000 | 600000 | 600000 | 600000 | 600000 | 1.4 % | 06/11/2017 |
| Foresite Capital Management III, LLC | Delaware | 600000 | 600000 | 600000 | 600000 | 600000 | 1.4 % | 06/11/2017 |
| Foresite Capital Fund IV, L.P. | Delaware | 2091792 | 2091792 | 2091792 | 2091792 | 2091792 | 4.7 % | 06/11/2017 |
| James Tananbaum | United States | 2691792 | 2691792 | 2691792 | 2691792 | 2691792 | 6.2 % | 06/11/2017 |
| JG Asset, LLC | United States | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2017 |
| Visium Asset Management, LP | United States | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2017 |
| JG Asset, LLC | United States | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2017 |
| Jacob Gottlieb | United States | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2017 |
| Jacob Gottlieb | United States | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2017 |
| Visium Asset Management, LP | United States | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2017 |
| Phillip Gross | United States | 0 | 1840044 | 0 | 1840044 | 1840044 | 6.43 % | 09/02/2017 |
| Phillip Gross | United States | 0 | 1840044 | 0 | 1840044 | 1840044 | 6.43 % | 09/02/2017 |
| Adage Capital Partners, L.P. | Delaware | 0 | 1840044 | 0 | 1840044 | 1840044 | 6.43 % | 09/02/2017 |
| Adage Capital Partners GP, L.L.C. | Delaware | 0 | 1840044 | 0 | 1840044 | 1840044 | 6.43 % | 09/02/2017 |
| Adage Capital Advisors, L.L.C. | Delaware | 0 | 1840044 | 0 | 1840044 | 1840044 | 6.43 % | 09/02/2017 |
| Robert Atchinson | United States | 0 | 1840044 | 0 | 1840044 | 1840044 | 6.43 % | 09/02/2017 |
| Adage Capital Partners, L.P. | Delaware | 0 | 1840044 | 0 | 1840044 | 1840044 | 6.43 % | 09/02/2017 |
| Adage Capital Partners GP, L.L.C. | Delaware | 0 | 1840044 | 0 | 1840044 | 1840044 | 6.43 % | 09/02/2017 |
| Adage Capital Advisors, L.L.C. | Delaware | 0 | 1840044 | 0 | 1840044 | 1840044 | 6.43 % | 09/02/2017 |
| Robert Atchinson | United States | 0 | 1840044 | 0 | 1840044 | 1840044 | 6.43 % | 09/02/2017 |
| Abingworth Bioequities Master Fund Limited | Cayman Islands | 0 | 0 | 0 | 0 | 1066666 | 4.5 % | 20/04/2016 |
| Abingworth Bioequities Master Fund Limited | Cayman Islands | 0 | 0 | 0 | 0 | 1066666 | 4.5 % | 20/04/2016 |
| Abingworth Bioventures VI, LP | England | 0 | 533334 | 0 | 533334 | 533334 | 2.3 % | 20/04/2016 |
| Abingworth LLP | England | 0 | 1600000 | 0 | 1600000 | 1600000 | 6.8 % | 20/04/2016 |
| Abingworth Bioventures VI, LP | England | 0 | 533334 | 0 | 533334 | 533334 | 2.3 % | 20/04/2016 |
| Abingworth LLP | England | 0 | 1600000 | 0 | 1600000 | 1600000 | 6.8 % | 20/04/2016 |
| EverPoint Asset Management, LLC | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 16/02/2016 |
| Steven A. Cohen | United States | 0 | 1035288 | 0 | 1035288 | 1035288 | 4.4 % | 16/02/2016 |
| Point72 Capital Advisors, Inc. | Delaware | 0 | 1035288 | 0 | 1035288 | 1035288 | 4.4 % | 16/02/2016 |
| Point72 Capital Advisors, Inc. | Delaware | 0 | 1035288 | 0 | 1035288 | 1035288 | 4.4 % | 16/02/2016 |
| Point72 Asset Management, L.P. | Delaware | 0 | 1035288 | 0 | 1035288 | 1035288 | 4.4 % | 16/02/2016 |
| Point72 Asset Management, L.P. | Delaware | 0 | 1035288 | 0 | 1035288 | 1035288 | 4.4 % | 16/02/2016 |
| Steven A. Cohen | United States | 0 | 1035288 | 0 | 1035288 | 1035288 | 4.4 % | 16/02/2016 |
| EverPoint Asset Management, LLC | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 16/02/2016 |
| Lombard Odier Asset Management (USA) Corp | Delaware | 0 | 1085681 | 0 | 1085681 | 1085681 | 4.63 % | 16/02/2016 |
| Lombard Odier Asset Management (USA) Corp | Delaware | 0 | 1085681 | 0 | 1085681 | 1085681 | 4.63 % | 16/02/2016 |
| Adage Capital Partners, L.P. | Delaware | 0 | 1700000 | 0 | 1700000 | 1700000 | 7.25 % | 16/02/2016 |
| Adage Capital Advisors, L.L.C. | Delaware | 0 | 1700000 | 0 | 1700000 | 1700000 | 7.25 % | 16/02/2016 |
| Robert Atchinson | United States | 0 | 1700000 | 0 | 1700000 | 1700000 | 7.25 % | 16/02/2016 |
| Phillip Gross | United States | 0 | 1700000 | 0 | 1700000 | 1700000 | 7.25 % | 16/02/2016 |
| Robert Atchinson | United States | 0 | 1700000 | 0 | 1700000 | 1700000 | 7.25 % | 16/02/2016 |
| Adage Capital Advisors, L.L.C. | Delaware | 0 | 1700000 | 0 | 1700000 | 1700000 | 7.25 % | 16/02/2016 |
| Adage Capital Partners GP, L.L.C. | Delaware | 0 | 1700000 | 0 | 1700000 | 1700000 | 7.25 % | 16/02/2016 |
| Adage Capital Partners, L.P. | Delaware | 0 | 1700000 | 0 | 1700000 | 1700000 | 7.25 % | 16/02/2016 |
| Phillip Gross | United States | 0 | 1700000 | 0 | 1700000 | 1700000 | 7.25 % | 16/02/2016 |
| Adage Capital Partners GP, L.L.C. | Delaware | 0 | 1700000 | 0 | 1700000 | 1700000 | 7.25 % | 16/02/2016 |
| Alta BioPharma Management III, LLC | Delaware | 0 | 1068429 | 0 | 1068429 | 1068429 | 4.5 % | 12/02/2016 |
| Alta BioPharma Partners III, L.P. | Delaware | 1001191 | 0 | 1001191 | 0 | 1001191 | 4.3 % | 12/02/2016 |
| Edward Penhoet | United States | 0 | 1093100 | 0 | 1093100 | 1093100 | 4.6 % | 12/02/2016 |
| Farah Champsi | United States | 0 | 1093100 | 0 | 1093100 | 1093100 | 4.6 % | 12/02/2016 |
| Alta Embarcadero BioPharma Partners III, LLC | California | 24671 | 0 | 24671 | 0 | 24671 | 0.1 % | 12/02/2016 |
| Alta BioPharma Partners III GmbH & Co. Beteiligungs KG | Germany | 67238 | 0 | 67238 | 0 | 67238 | 0.3 % | 12/02/2016 |
| Jacob Gottlieb | United States | 0 | 321158 | 0 | 321158 | 321158 | 1.4 % | 12/02/2016 |
| JG Asset, LLC | United States | 0 | 321158 | 0 | 321158 | 321158 | 1.4 % | 12/02/2016 |
| Visium Asset Management, LP | United States | 0 | 321158 | 0 | 321158 | 321158 | 1.4 % | 12/02/2016 |
| Samuel D. Colella | United States America | 0 | 1123600 | 0 | 1123600 | 1123600 | 4.8 % | 09/02/2016 |
| Ross A. Jaffe | United States America | 0 | 1123600 | 0 | 1123600 | 1123600 | 4.8 % | 09/02/2016 |
| Charles M. Warden | United States America | 0 | 1123600 | 0 | 1123600 | 1123600 | 4.8 % | 09/02/2016 |
| Bradley J. Bolzon | Canada | 0 | 1123600 | 0 | 1123600 | 1123600 | 4.8 % | 09/02/2016 |
| William J. Link | United States America | 0 | 1123600 | 0 | 1123600 | 1123600 | 4.8 % | 09/02/2016 |
| Versant Ventures II, LLC | Delaware United States America | 0 | 1123600 | 0 | 1123600 | 1123600 | 4.8 % | 09/02/2016 |
| Donald B. Milder | United States America | 0 | 1123600 | 0 | 1123600 | 1123600 | 4.8 % | 09/02/2016 |
| Rebecca B. Robertson | United States America | 0 | 1123600 | 0 | 1123600 | 1123600 | 4.8 % | 09/02/2016 |
| Barbara N. Lubash | United States America | 0 | 1123600 | 0 | 1123600 | 1123600 | 4.8 % | 09/02/2016 |
| Versant Affiliates Fund IIA, L.P. | Delaware United States America | 20742 | 0 | 20742 | 0 | 20742 | 0.1 % | 09/02/2016 |
| Versant Side Fund II, L.P. | Delaware United States America | 9768 | 0 | 9768 | 0 | 9768 | 0.1 % | 09/02/2016 |
| Versant Venture Capital II, L.P. | Delaware United States America | 1093090 | 0 | 1093090 | 0 | 1093090 | 4.7 % | 09/02/2016 |
| Brian G. Atwood | United States America | 0 | 1123600 | 0 | 1123600 | 1123600 | 4.8 % | 09/02/2016 |
| Jennison Associates LLC S.S. or | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 03/02/2016 |
| Steven A. Cohen | United States | 0 | 1318282 | 0 | 1318282 | 1318282 | 9 % | 17/02/2015 |
| Point72 Capital Advisors, Inc. | Delaware | 0 | 571088 | 0 | 571088 | 571088 | 3.9 % | 17/02/2015 |
| Point72 Capital Advisors, Inc. | Delaware | 0 | 571088 | 0 | 571088 | 571088 | 3.9 % | 17/02/2015 |
| Point72 Asset Management, L.P. | Delaware | 0 | 571088 | 0 | 571088 | 571088 | 3.9 % | 17/02/2015 |
| Steven A. Cohen | United States | 0 | 1318282 | 0 | 1318282 | 1318282 | 9 % | 17/02/2015 |
| EverPoint Asset Management, LLC | Delaware | 0 | 747194 | 0 | 747194 | 747194 | 5.1 % | 17/02/2015 |
| Point72 Asset Management, L.P. | Delaware | 0 | 571088 | 0 | 571088 | 571088 | 3.9 % | 17/02/2015 |
| EverPoint Asset Management, LLC | Delaware | 0 | 747194 | 0 | 747194 | 747194 | 5.1 % | 17/02/2015 |
| James E. Flynn | United States | 0 | 80000 | 0 | 80000 | 80000 | 0.54 % | 17/02/2015 |
| Deerfield Management Company, L.P. | Delaware | 0 | 80000 | 0 | 80000 | 80000 | 0.54 % | 17/02/2015 |
| Deerfield Mgmt, L.P. | Delaware | 0 | 80000 | 0 | 80000 | 80000 | 0.54 % | 17/02/2015 |
| Deerfield Mgmt, L.P. | Delaware | 0 | 80000 | 0 | 80000 | 80000 | 0.54 % | 17/02/2015 |
| Deerfield Special Situations International Master Fund, L.P. | British Virgin Islands | 0 | 35920 | 0 | 35920 | 35920 | 0.24 % | 17/02/2015 |
| Deerfield Special Situations Fund, L.P. | Delaware | 0 | 44080 | 0 | 44080 | 44080 | 0.3 % | 17/02/2015 |
| Deerfield Management Company, L.P. | Delaware | 0 | 80000 | 0 | 80000 | 80000 | 0.54 % | 17/02/2015 |
| James E. Flynn | United States | 0 | 80000 | 0 | 80000 | 80000 | 0.54 % | 17/02/2015 |
| Deerfield Special Situations International Master Fund, L.P. | British Virgin Islands | 0 | 35920 | 0 | 35920 | 35920 | 0.24 % | 17/02/2015 |
| Deerfield Special Situations Fund, L.P. | Delaware | 0 | 44080 | 0 | 44080 | 44080 | 0.3 % | 17/02/2015 |
| Rebecca B. Robertson | United States America | 0 | 1123600 | 0 | 1123600 | 1123600 | 7.7 % | 17/02/2015 |
| Barbara N. Lubash | United States America | 0 | 1123600 | 0 | 1123600 | 1123600 | 7.7 % | 17/02/2015 |
| Charles M. Warden | United States America | 0 | 1123600 | 0 | 1123600 | 1123600 | 7.7 % | 17/02/2015 |
| Donald B. Milder | United States America | 0 | 1123600 | 0 | 1123600 | 1123600 | 7.7 % | 17/02/2015 |
| Versant Side Fund II, L.P. | Delaware United States America | 9768 | 0 | 9768 | 0 | 9768 | 0.1 % | 17/02/2015 |
| Versant Ventures II, LLC | Delaware United States America | 0 | 1123600 | 0 | 1123600 | 1123600 | 7.7 % | 17/02/2015 |
| Versant Affiliates Fund IIA, L.P. | Delaware United States America | 20742 | 0 | 20742 | 0 | 20742 | 0.1 % | 17/02/2015 |
| Brian G. Atwood | United States America | 0 | 1123600 | 0 | 1123600 | 1123600 | 7.7 % | 17/02/2015 |
| Ross A. Jaffe | United States America | 0 | 1123600 | 0 | 1123600 | 1123600 | 7.7 % | 17/02/2015 |
| William J. Link | United States America | 0 | 1123600 | 0 | 1123600 | 1123600 | 7.7 % | 17/02/2015 |
| Samuel D. Colella | United States America | 0 | 1123600 | 0 | 1123600 | 1123600 | 7.7 % | 17/02/2015 |
| Versant Venture Capital II, L.P. | Delaware United States America | 1093090 | 0 | 1093090 | 0 | 1093090 | 7.4 % | 17/02/2015 |
| Bradley J. Bolzon | Canada | 0 | 1123600 | 0 | 1123600 | 1123600 | 7.7 % | 17/02/2015 |
| Alta Embarcadero BioPharma Partners III, LLC | California | 25360 | 0 | 25360 | 0 | 25360 | 0.2 % | 12/02/2015 |
| Farah Champsi | United States | 0 | 1123600 | 0 | 1123600 | 1123600 | 7.7 % | 12/02/2015 |
| Edward Penhoet | United States | 3597 | 1123600 | 3597 | 1123600 | 1127197 | 7.7 % | 12/02/2015 |
| Alta BioPharma Partners III, L.P. | Delaware | 1029126 | 0 | 1029126 | 0 | 1029126 | 7 % | 12/02/2015 |
| Alta BioPharma Partners III GmbH & Co. Beteiligungs KG | Germany | 69114 | 0 | 69114 | 0 | 69114 | 0.5 % | 12/02/2015 |
| Alta BioPharma Management III, LLC | Delaware | 0 | 1098240 | 0 | 1098240 | 1098240 | 7.5 % | 12/02/2015 |
| Jennison Associates LLC S.S. or I.R.S. Identification No. of Above Person: IRS Identification (formerly | Delaware | 993500 | 0 | 0 | 993500 | 993500 | 6.8 % | 11/02/2015 |
| Lombard Odier Asset Management (USA) Corp | Delaware | 0 | 1368557 | 0 | 1368557 | 1368557 | 9.32 % | 11/02/2015 |
| Visium Balanced Master Fund, Ltd. | Cayman Islands | 0 | 1000000 | 0 | 1000000 | 1000000 | 6.8 % | 29/01/2015 |
| Visium Asset Management, LP | United States | 0 | 1000000 | 0 | 1000000 | 1000000 | 6.8 % | 29/01/2015 |
| JG Asset, LLC | United States | 0 | 1000000 | 0 | 1000000 | 1000000 | 6.8 % | 29/01/2015 |
| Visium Balanced Master Fund, Ltd. | Cayman Islands | 0 | 1000000 | 0 | 1000000 | 1000000 | 6.8 % | 29/01/2015 |
| Visium Asset Management, LP | United States | 0 | 1000000 | 0 | 1000000 | 1000000 | 6.8 % | 29/01/2015 |
| JG Asset, LLC | United States | 0 | 1000000 | 0 | 1000000 | 1000000 | 6.8 % | 29/01/2015 |
| Jacob Gottlieb | United States | 0 | 1000000 | 0 | 1000000 | 1000000 | 6.8 % | 29/01/2015 |
| Jacob Gottlieb | United States | 0 | 1000000 | 0 | 1000000 | 1000000 | 6.8 % | 29/01/2015 |
| Robert Atchinson | United States | 0 | 1000000 | 0 | 1000000 | 1000000 | 6.8 % | 23/01/2015 |
| Phillip Gross | United States | 0 | 1000000 | 0 | 1000000 | 1000000 | 6.8 % | 23/01/2015 |
| Adage Capital Partners GP, L.L.C. | Delaware | 0 | 1000000 | 0 | 1000000 | 1000000 | 6.8 % | 23/01/2015 |
| Adage Capital Partners, L.P. | Delaware | 0 | 1000000 | 0 | 1000000 | 1000000 | 6.8 % | 23/01/2015 |
| Phillip Gross | United States | 0 | 1000000 | 0 | 1000000 | 1000000 | 6.8 % | 23/01/2015 |
| Adage Capital Advisors, L.L.C. | Delaware | 0 | 1000000 | 0 | 1000000 | 1000000 | 6.8 % | 23/01/2015 |
| Adage Capital Partners, L.P. | Delaware | 0 | 1000000 | 0 | 1000000 | 1000000 | 6.8 % | 23/01/2015 |
| Adage Capital Partners GP, L.L.C. | Delaware | 0 | 1000000 | 0 | 1000000 | 1000000 | 6.8 % | 23/01/2015 |
| Adage Capital Advisors, L.L.C. | Delaware | 0 | 1000000 | 0 | 1000000 | 1000000 | 6.8 % | 23/01/2015 |
| Robert Atchinson | United States | 0 | 1000000 | 0 | 1000000 | 1000000 | 6.8 % | 23/01/2015 |
| Point72 Asset Management, L.P. | Delaware | 0 | 229883 | 0 | 229883 | 229883 | 1.6 % | 06/10/2014 |
| Steven A. Cohen | United States | 0 | 844883 | 0 | 844883 | 844883 | 5.8 % | 06/10/2014 |
| EverPoint Asset Management, LLC | Delaware | 0 | 615000 | 0 | 615000 | 615000 | 4.2 % | 06/10/2014 |
| Point72 Capital Advisors, Inc. | Delaware | 0 | 229883 | 0 | 229883 | 229883 | 1.6 % | 06/10/2014 |
| Point72 Asset Management, L.P. | Delaware | 0 | 229883 | 0 | 229883 | 229883 | 1.6 % | 06/10/2014 |
| Steven A. Cohen | United States | 0 | 844883 | 0 | 844883 | 844883 | 5.8 % | 06/10/2014 |
| EverPoint Asset Management, LLC | Delaware | 0 | 615000 | 0 | 615000 | 615000 | 4.2 % | 06/10/2014 |
| Point72 Capital Advisors, Inc. | Delaware | 0 | 229883 | 0 | 229883 | 229883 | 1.6 % | 06/10/2014 |
| Deerfield Management Company, L.P. | Delaware | 0 | 593206 | 0 | 593206 | 593206 | 5.85 % | 08/04/2014 |
| Deerfield Special Situations International Master Fund, L.P. | British Virgin Islands | 0 | 290991 | 0 | 290991 | 290991 | 2.88 % | 08/04/2014 |
| Deerfield Management Company, L.P. | Delaware | 0 | 593206 | 0 | 593206 | 593206 | 5.85 % | 08/04/2014 |
| Deerfield Special Situations Fund, L.P. | Delaware | 0 | 302215 | 0 | 302215 | 302215 | 2.99 % | 08/04/2014 |
| Deerfield Special Situations International Master Fund, L.P. | British Virgin Islands | 0 | 290991 | 0 | 290991 | 290991 | 2.88 % | 08/04/2014 |
| James E. Flynn | United States | 0 | 593206 | 0 | 593206 | 593206 | 5.85 % | 08/04/2014 |
| Deerfield Mgmt, L.P. | Delaware | 0 | 593206 | 0 | 593206 | 593206 | 5.85 % | 08/04/2014 |
| James E. Flynn | United States | 0 | 593206 | 0 | 593206 | 593206 | 5.85 % | 08/04/2014 |
| Deerfield Special Situations Fund, L.P. | Delaware | 0 | 302215 | 0 | 302215 | 302215 | 2.99 % | 08/04/2014 |
| Deerfield Mgmt, L.P. | Delaware | 0 | 593206 | 0 | 593206 | 593206 | 5.85 % | 08/04/2014 |
| Edward Hurwitz | United States | 0 | 1123600 | 0 | 1123600 | 1123600 | 11.79 % | 14/02/2014 |
| Alta BioPharma Partners III, L.P. | Delaware | 1029126 | 0 | 1029126 | 0 | 1029126 | 10.81 % | 14/02/2014 |
| Edward Penhoet | United States | 0 | 1123600 | 0 | 1123600 | 1123600 | 11.79 % | 14/02/2014 |
| Farah Champsi | United States | 0 | 1123600 | 0 | 1123600 | 1123600 | 11.79 % | 14/02/2014 |
| Alta BioPharma Management III, LLC | Delaware | 0 | 1098240 | 0 | 1098240 | 1098240 | 11.53 % | 14/02/2014 |
| Alta BioPharma Partners III GmbH & Co. Beteiligungs KG | Germany | 69114 | 0 | 69114 | 0 | 69114 | 0.73 % | 14/02/2014 |
| Alta Embarcadero BioPharma Partners III, LLC | California | 25360 | 0 | 25360 | 0 | 25360 | 0.27 % | 14/02/2014 |