| (1) BlackRock, Inc. |
Delaware |
4355767 |
0 |
0 |
0 |
4633276 |
9.5 % |
08/11/2024 |
| (1) BlackRock, Inc. |
Delaware |
0 |
0 |
4633276 |
0 |
4633276 |
9.5 % |
21/10/2024 |
| Bihua Chen |
United States |
0 |
2500000 |
0 |
2500000 |
2500000 |
5.15 % |
29/04/2024 |
| Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
0 |
2500000 |
0 |
2500000 |
2500000 |
5.15 % |
29/04/2024 |
| Bihua Chen |
Cayman Islands |
0 |
2500000 |
0 |
2500000 |
2500000 |
5.15 % |
29/04/2024 |
| Cormorant Asset Management, LP |
Cayman Islands |
0 |
2500000 |
0 |
2500000 |
2500000 |
5.15 % |
29/04/2024 |
| Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
0 |
2500000 |
0 |
2500000 |
2500000 |
5.15 % |
29/04/2024 |
| Cormorant Global Healthcare GP, LLC |
Delaware |
0 |
2500000 |
0 |
2500000 |
2500000 |
5.15 % |
29/04/2024 |
| Cormorant Global Healthcare GP, LLC |
Cayman Islands |
0 |
2500000 |
0 |
2500000 |
2500000 |
5.15 % |
29/04/2024 |
| Cormorant Asset Management, LP |
Delaware |
0 |
2500000 |
0 |
2500000 |
2500000 |
5.15 % |
29/04/2024 |
| Phillip Gross |
United States |
0 |
4000000 |
0 |
0 |
4000000 |
9.35 % |
12/06/2023 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
4000000 |
0 |
0 |
4000000 |
9.35 % |
12/06/2023 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
4000000 |
0 |
0 |
4000000 |
9.35 % |
12/06/2023 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
4000000 |
0 |
0 |
4000000 |
9.35 % |
12/06/2023 |
| Robert Atchinson |
Delaware |
0 |
4000000 |
0 |
0 |
4000000 |
9.35 % |
12/06/2023 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
4000000 |
0 |
0 |
4000000 |
9.35 % |
12/06/2023 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
4000000 |
0 |
0 |
4000000 |
9.35 % |
12/06/2023 |
| Phillip Gross |
Delaware |
0 |
4000000 |
0 |
0 |
4000000 |
9.35 % |
12/06/2023 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
4000000 |
0 |
0 |
4000000 |
9.35 % |
12/06/2023 |
| Robert Atchinson |
United States |
0 |
4000000 |
0 |
0 |
4000000 |
9.35 % |
12/06/2023 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
3023416 |
3023416 |
6.8 % |
05/06/2023 |
| BVF Partners L.P. |
Delaware |
0 |
0 |
0 |
4414910 |
4414910 |
9.99 % |
05/06/2023 |
| BVF Partners OS Ltd. |
Delaware |
0 |
0 |
0 |
140576 |
140576 |
1 % |
05/06/2023 |
| BVF Inc. |
Delaware |
0 |
0 |
0 |
4414910 |
4414910 |
9.99 % |
05/06/2023 |
| BVF GP Holdings LLC |
Delaware |
0 |
0 |
0 |
4234021 |
4234021 |
9.6 % |
05/06/2023 |
| Biotechnology Value Trading Fund OS LP |
Delaware |
0 |
0 |
0 |
140576 |
140576 |
1 % |
05/06/2023 |
| BVF II GP LLC |
Delaware |
0 |
0 |
0 |
1210605 |
1210605 |
2.8 % |
05/06/2023 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
1210605 |
1210605 |
2.8 % |
05/06/2023 |
| Mark N. Lampert |
Delaware |
0 |
0 |
0 |
4414910 |
4414910 |
9.99 % |
05/06/2023 |
| BVF Inc. |
Delaware |
0 |
0 |
0 |
4414910 |
4414910 |
9.99 % |
05/06/2023 |
| BVF GP Holdings LLC |
Delaware |
0 |
0 |
0 |
4234021 |
4234021 |
9.6 % |
05/06/2023 |
| BVF Partners OS Ltd. |
Delaware |
0 |
0 |
0 |
140576 |
140576 |
1 % |
05/06/2023 |
| Biotechnology Value Trading Fund OS LP |
Delaware |
0 |
0 |
0 |
140576 |
140576 |
1 % |
05/06/2023 |
| BVF I GP LLC |
Delaware |
0 |
0 |
0 |
3023416 |
3023416 |
6.8 % |
05/06/2023 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
3023416 |
3023416 |
6.8 % |
05/06/2023 |
| BVF Partners L.P. |
Delaware |
0 |
0 |
0 |
4414910 |
4414910 |
9.99 % |
05/06/2023 |
| BVF I GP LLC |
Delaware |
0 |
0 |
0 |
3023416 |
3023416 |
6.8 % |
05/06/2023 |
| BVF II GP LLC |
Delaware |
0 |
0 |
0 |
1210605 |
1210605 |
2.8 % |
05/06/2023 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
1210605 |
1210605 |
2.8 % |
05/06/2023 |
| Mark N. Lampert |
Delaware |
0 |
0 |
0 |
4414910 |
4414910 |
9.99 % |
05/06/2023 |
| Oleg Nodelman |
Delaware |
0 |
5000000 |
0 |
5000000 |
5000000 |
11 % |
05/06/2023 |
| EcoR1 Capital, LLC |
Delaware |
0 |
5000000 |
0 |
5000000 |
5000000 |
11 % |
05/06/2023 |
| EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
4640415 |
0 |
4640415 |
4640415 |
11 % |
05/06/2023 |
| EcoR1 Capital, LLC |
Delaware |
0 |
5000000 |
0 |
5000000 |
5000000 |
11 % |
05/06/2023 |
| EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
4640415 |
0 |
4640415 |
4640415 |
11 % |
05/06/2023 |
| Oleg Nodelman |
Delaware |
0 |
5000000 |
0 |
5000000 |
5000000 |
11 % |
05/06/2023 |
| Weston Nichols |
Delaware |
0 |
5224600 |
0 |
0 |
5224600 |
12.2 % |
02/06/2023 |
| Lynx1 Capital Management LP |
Delaware |
0 |
5224600 |
0 |
0 |
5224600 |
12.2 % |
02/06/2023 |
| Weston Nichols |
Delaware |
0 |
5224600 |
0 |
0 |
5224600 |
12.2 % |
02/06/2023 |
| Lynx1 Capital Management LP |
Delaware |
0 |
5224600 |
0 |
0 |
5224600 |
12.2 % |
02/06/2023 |
| Anup Arora |
Delaware |
0 |
2099809 |
0 |
2099809 |
2099809 |
9.985 % |
30/09/2022 |
| Parag Shah |
Delaware |
0 |
2099809 |
0 |
2099809 |
2099809 |
9.985 % |
30/09/2022 |
| Anup Arora |
Delaware |
0 |
2099809 |
0 |
2099809 |
2099809 |
9.985 % |
30/09/2022 |
| K2 HealthVentures Equity Trust LLC |
Delaware |
0 |
2099809 |
0 |
2099809 |
2099809 |
9.985 % |
30/09/2022 |
| K2 HealthVentures Equity Trust LLC |
Delaware |
0 |
2099809 |
0 |
2099809 |
2099809 |
9.985 % |
30/09/2022 |
| Parag Shah |
Delaware |
0 |
2099809 |
0 |
2099809 |
2099809 |
9.985 % |
30/09/2022 |
| RA Capital Management, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
15/08/2022 |
| Peter Kolchinsky |
United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
15/08/2022 |
| Rajeev Shah |
United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
15/08/2022 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
15/08/2022 |
| Deer IX & Co. L.P. |
Cayman Islands |
1245505 |
0 |
1245505 |
0 |
1245505 |
6.7 % |
14/02/2022 |
| Bessemer Venture Partners IX Institutional L.P. |
Cayman Islands |
554000 |
0 |
554000 |
0 |
554000 |
3 % |
14/02/2022 |
| Deer IX & Co. L.P. |
Cayman Islands |
1245505 |
0 |
1245505 |
0 |
1245505 |
6.7 % |
14/02/2022 |
| Deer IX & Co. Ltd. |
Cayman Islands |
1245505 |
0 |
1245505 |
0 |
1245505 |
6.7 % |
14/02/2022 |
| Bessemer Venture Partners IX Institutional L.P. |
Cayman Islands |
554000 |
0 |
554000 |
0 |
554000 |
3 % |
14/02/2022 |
| Deer IX & Co. Ltd. |
Cayman Islands |
1245505 |
0 |
1245505 |
0 |
1245505 |
6.7 % |
14/02/2022 |
| Bessemer Venture Partners IX L.P. |
Cayman Islands |
691505 |
0 |
691505 |
0 |
691505 |
3.7 % |
14/02/2022 |
| Bessemer Venture Partners IX L.P. |
Cayman Islands |
691505 |
0 |
691505 |
0 |
691505 |
3.7 % |
14/02/2022 |
| Hillhouse Investment Management, Ltd. |
|
1282976 |
0 |
1282976 |
0 |
1282976 |
6.9 % |
14/02/2022 |
| Hillhouse Investment Management, Ltd. |
Cayman Islands |
1282976 |
0 |
1282976 |
0 |
1282976 |
6.9 % |
14/02/2022 |
| Alphabet Holdings LLC |
Delaware |
1077080 |
1077080 |
1077080 |
0 |
1077080 |
5.78 % |
14/02/2022 |
| Alphabet Inc. |
Delaware |
1077080 |
1077080 |
1077080 |
0 |
1077080 |
5.78 % |
14/02/2022 |
| GV 2017 GP, L.L.C. |
Delaware |
641848 |
641848 |
641848 |
0 |
641848 |
3.45 % |
14/02/2022 |
| XXVI Holdings Inc. |
Delaware |
1077080 |
1077080 |
1077080 |
0 |
1077080 |
5.78 % |
14/02/2022 |
| GV 2017, L.P. |
Delaware |
641848 |
641848 |
641848 |
0 |
641848 |
3.45 % |
14/02/2022 |
| GV 2019 GP, L.L.C. |
Delaware |
435232 |
435232 |
435232 |
0 |
435232 |
2.34 % |
14/02/2022 |
| GV 2019, L.P. |
Delaware |
641848 |
641848 |
641848 |
641848 |
435232 |
2.34 % |
14/02/2022 |
| GV 2019, L.P. |
Delaware |
435232 |
435232 |
435232 |
0 |
435232 |
2.34 % |
14/02/2022 |
| GV 2017 GP, L.P. |
Delaware |
641848 |
641848 |
641848 |
0 |
641848 |
3.45 % |
14/02/2022 |
| GV 2019 GP, L.P. |
Delaware |
435232 |
435232 |
435232 |
0 |
435232 |
2.34 % |
14/02/2022 |
| Pitango HealthTech Fund I - Israel L.P. |
Israel |
7498 |
0 |
7498 |
0 |
7498 |
0.03 % |
14/02/2022 |
| Pitango HealthTech Principals Fund I, L.P. |
|
22591 |
0 |
22591 |
0 |
22591 |
0.1 % |
14/02/2022 |
| Pitango HealthTech Principals Fund I, L.P. |
Cayman Islands |
22591 |
0 |
22591 |
0 |
22591 |
0.1 % |
14/02/2022 |
| Pitango HealthTech Fund I, L.P. |
Cayman Islands |
1049896 |
0 |
1049896 |
0 |
1049896 |
4.4 % |
14/02/2022 |
| Pitango H.T. Fund I, L.P. |
|
0 |
1079985 |
0 |
1079985 |
1079985 |
4.6 % |
14/02/2022 |
| Pitango H.T. Fund I, L.P. |
Cayman Islands |
0 |
1079985 |
0 |
1079985 |
1079985 |
4.6 % |
14/02/2022 |
| Pitango HealthTech Fund I - Israel L.P. |
|
7498 |
0 |
7498 |
0 |
7498 |
0.03 % |
14/02/2022 |
| Pitango HealthTech Fund I, L.P. |
|
1049896 |
0 |
1049896 |
0 |
1049896 |
4.4 % |
14/02/2022 |
| Longwood Fund IV, L.P. |
|
0 |
1278838 |
0 |
1278838 |
1278838 |
6.9 % |
10/02/2022 |
| Longwood Fund IV GP, LLC |
|
0 |
1278838 |
0 |
1278838 |
1278838 |
6.9 % |
10/02/2022 |
| Christoph H. Westphal |
|
1036585 |
1278838 |
1036585 |
1278838 |
2315423 |
12.4 % |
10/02/2022 |
| Longwood Fund IV, L.P. |
|
0 |
1278838 |
0 |
1278838 |
1278838 |
6.9 % |
10/02/2022 |
| Longwood Fund IV GP, LLC |
|
0 |
1278838 |
0 |
1278838 |
1278838 |
6.9 % |
10/02/2022 |
| Christoph H. Westphal |
|
1036585 |
1278838 |
1036585 |
1278838 |
2315423 |
12.4 % |
10/02/2022 |
| (1)Names of reporting persons. BlackRock, Inc. |
Delaware |
1498538 |
0 |
1498538 |
0 |
1498538 |
8 % |
04/02/2022 |
| Peter Kolchinsky |
Delaware |
0 |
1255317 |
0 |
1255317 |
1255317 |
6.7 % |
28/07/2021 |
| Peter Kolchinsky |
United States of America |
0 |
1255317 |
0 |
1255317 |
1255317 |
6.7 % |
28/07/2021 |
| Rajeev Shah |
Delaware |
0 |
1255317 |
0 |
0 |
1255317 |
6.7 % |
28/07/2021 |
| Rajeev Shah |
United States of America |
0 |
1255317 |
0 |
0 |
1255317 |
6.7 % |
28/07/2021 |
| RA Capital Management, L.P. |
Delaware |
0 |
1255317 |
0 |
0 |
1255317 |
6.7 % |
28/07/2021 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
1101579 |
0 |
0 |
1101579 |
5.9 % |
28/07/2021 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
1101579 |
0 |
0 |
1101579 |
5.9 % |
28/07/2021 |
| RA Capital Management, L.P. |
Delaware |
0 |
1255317 |
0 |
0 |
1255317 |
6.7 % |
28/07/2021 |
| Felix J. Baker |
United States |
1425000 |
0 |
1425000 |
0 |
1425000 |
7.6 % |
22/07/2021 |
| Baker Bros. Advisors (GP) LLC |
Delaware |
1425000 |
0 |
1425000 |
0 |
1425000 |
7.6 % |
22/07/2021 |
| Felix J. Baker |
|
1425000 |
0 |
1425000 |
0 |
1425000 |
7.6 % |
22/07/2021 |
| Baker Bros. Advisors (GP) LLC |
|
1425000 |
0 |
1425000 |
0 |
1425000 |
7.6 % |
22/07/2021 |
| Baker Bros. Advisors LP |
|
1425000 |
0 |
1425000 |
0 |
1425000 |
7.6 % |
22/07/2021 |
| Julian C. Baker |
United States |
1425000 |
0 |
1425000 |
0 |
1425000 |
7.6 % |
22/07/2021 |
| Baker Bros. Advisors LP |
Delaware |
1425000 |
0 |
1425000 |
0 |
1425000 |
7.6 % |
22/07/2021 |
| Julian C. Baker |
|
1425000 |
0 |
1425000 |
0 |
1425000 |
7.6 % |
22/07/2021 |